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Synthèse de nanogels biocompatibles et multi-stimulables pour la libération contrôlée d'une molécule modèle par hyperthermie magnétique et photothermie

Abstract : Hybrid nanogels, composed of thermoresponsive polymers and inorganic responsive nanoparticles, such as magnetic nanoparticles (NPMs) and gold nanorods (AuNRs) are highly interesting for biomedical applications. Their polymeric matrix makes them able to uptake and release high quantities of drugs, whereas nanoparticles can generate heat when exposed to an alternating magnetic field (AMF) for NPMs, and to a near-infrared light for AuNRs. This thesis manuscript focuses on the synthesis and the characterization of biocompatible, pH- and thermoresponsive nanogels, based on oligo(ethylene glycol) monomers (OEGMAs), methacrylic acid (MAA) and encapsulating NPMs and/or AuNR for remotely triggered doxorubicin (DOX, anticancer drug) release, by magnetic hyperthermia or phothothermia. Hybrid magnetic, plasmonic and magneto-plasmonic nanogels were synthesized. Theses nanogels have a hydrodynamic diameter between 200 and 500 nm and a volume phase transition temperature (VPTT) from 30 to 54°C. The nanogels’ swelling-deswelling behavior can be induced by several stimuli (temperature, pH, AMF, NIR-L). These results demonstrate that MagNanoGels are excellent nanocarriers for enhancing cellular internalization enhancing DOX cytotoxicity and that DOX release was significantly enhanced upon exposure to AMF in athermic conditions. In addition, PlasMagNanoGels can efficiently generate heat by photothermy for thermotherapy. Therefore, the intrinsic properties of NPMs for magnetic targeting and as contrast agents for Magnetic Resonance Imaging (MRI), make these nanogels ideal candidates for a new therapeutic approach (diagnosis and treatment) against cancer.
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https://tel.archives-ouvertes.fr/tel-01820615
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Submitted on : Friday, June 22, 2018 - 3:41:52 AM
Last modification on : Sunday, October 25, 2020 - 4:53:25 PM
Long-term archiving on: : Monday, September 24, 2018 - 5:13:29 PM

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2017PA066290.pdf
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  • HAL Id : tel-01820615, version 1

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Esther del Carmen Cázares Cortés. Synthèse de nanogels biocompatibles et multi-stimulables pour la libération contrôlée d'une molécule modèle par hyperthermie magnétique et photothermie. Chimie-Physique [physics.chem-ph]. Université Pierre et Marie Curie - Paris VI, 2017. Français. ⟨NNT : 2017PA066290⟩. ⟨tel-01820615⟩

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