Adaptive optics for fluorescence correlation spectroscopy

Abstract : This research project combines two complementary aspects: the development of an assembly incorporating an Adaptive Optics microscope system and the study of cancerous masses (multicellular spheroids) under mechanical pressure.These two axes are mutually beneficial since the implementation of the adaptive optics will enable imaging and physical measurements in spheroids; On the other hand, the study of spheroids will characterize the aberrations induced by this type of samples and understand the requirements of the adaptive optics system imposed by the observation of these samples as well as the limits of optical microscopy in biological tissues.
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Joseph Gallagher. Adaptive optics for fluorescence correlation spectroscopy. Instrumentation and Detectors [physics.ins-det]. Université Grenoble Alpes, 2017. English. ⟨NNT : 2017GREAY054⟩. ⟨tel-01819084⟩

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