T. Morris-lecal-model and .. ,

A. For-bursting-immature-sacs and .. , , p.20

D. Deriving-sahp, 22 Saturated calmodulin production 22 Binding of calmodulin to SK terminals 23 Calcium concentration, 23 Calcium concentration dynamics. . . . . . . . . . . . . . . 23

, Full set of equations for the single SAC dynamics, p.25

R. Equations and . Multi-time-scale-analysis........, , p.25

F. Parameters, , p.25

U. , 25 Calibrating parameters from experiments, p.26

A. and .. , , p.26

P. , , p.26

E. Comparison-with, , p.26

.. Bifurcations and N. , 28 Slow-fast analysis 28 Dynamical changes with respect to parameters variations. 28 Dynamically driven bursting, 29 Robustness with respect to parameters variations. . . . . 33 CONTENTS Fast dynamics of V, p.111

.. Slow, , p.112

V. Medium-scale, , p.112

.. Equation-of-transport-for-ach, , p.112

. Ach-production-on-the-lower-branch........, , p.113

. Ach-production-on-the-upper-branch........, , p.113

T. , , p.113

?. Variable, , p.113

A. Piecewise-linear, , p.114

.. Laplacian-approximation, 114 Singular diffusion, p.114

C. , , p.115

D. , 115 Single neuron dynamics in the presence of a tunable sAHP and Ach currents, p.115

, Confronting our model to experimental recordings 119

, The role of potassium channels in waves characteristics, p.119

.. , Exploring the effect of the cholinergic transmission on the spatio-temporal patterns of stage II retinal waves, p.125

.. Objective-of-the-experiment, , p.125

P. , , p.125

.. Tissue-preparation, 125 Recordings of retinal waves with MEA of 256 electrodes . 125 Analysis of the MEA recordings, p.125

, The effect of hexametonium in early stage II retinal waves, p.126

, The effect of atropine in early stage II retinal waves, p.129

.. Power, , p.133

D. Conclusion, , p.134

, 7 Conclusions and Perspectives 137

.. Reflecting-on-possible-theoretical-extensions, 137 Synaptic coupling versus volume diffusion, p.137

.. , The role of variability in SACs on waves generation. . . . 138 Extending our model towards a generic dynamical system for retinal waves, p.139

, Can we use retinal waves to restore plasticity in pathological retinas, p.139

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