, Supporting information S1 Fig. DnaJ-1 and MLF interact in Kc167 cells
, A) Confocal images of fluorescent immunostainings against GFP (green) and HA (red) in
, Kc167 cells transfected with expression plasmids for GFP-DnaJ-1 and HA-MLF. Nuclei were stained with Topro3. Merged and individual channels are displayed
, Western blots showing the results of an immunoprecipitation experiment against GFP in Kc167 cells transfected with expression plasmids for the indicated proteins
, S2 Fig. LZ interacts with MLF and DnaJ-1
, A) Autoradiogram showing the results of pull down assays between in vitro translated 35 Smethionine-labeled LZ and the indicated GST fusion proteins
Western blots showing the results of immunoprecipitation experiments against GFP performed in Kc167 cells transfected with expression vectors for GFP-LZ and various HA-MLF (B) or HA-DnaJ-1 (C) mutants ,
, S9 Fig. LZ expression increases with lz>GFP + cell size
, Quantification of LZ and NICD expression levels in lz>GFP + circulating blood cells of lz-GAL4, UAS-mCD8GFP/+ third instar larvae. Cells were pooled into 5 categories according to their size (% of the mean cell size) and LZ or NICD expression level in each pool was plotted
Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity, BMC Cell Biol, vol.7, issue.21, 2006. ,
HSP70 sequestration by free ??-globin promotes ineffective erythropoiesis in ??-thalassaemia, Nature, vol.240, issue.7521, pp.242-246, 2014. ,
DOI : 10.1085/jgp.13.4.469
The role of a Runt domain transcription factor AML1/RUNX1 in leukemogenesis and its clinical implications, Critical Reviews in Oncology/Hematology, vol.45, issue.2, pp.129-150, 2003. ,
DOI : 10.1016/S1040-8428(02)00003-3
Haemocytes control stem cell activity in the Drosophila??intestine, Nature Cell Biology, vol.9, issue.6, pp.736-748, 2015. ,
DOI : 10.1126/stke.2202004pl6
Phosphorylation, acetylation and ubiquitination: The molecular basis of RUNX regulation, Gene, vol.366, issue.1, pp.58-66, 2006. ,
DOI : 10.1016/j.gene.2005.10.017
Modulation of mutant Huntingtin aggregates and toxicity by human myeloid leukemia factors, The International Journal of Biochemistry & Cell Biology, vol.82, pp.1-9, 2017. ,
DOI : 10.1016/j.biocel.2016.11.008
DNA Recognition by the RUNX1 Transcription Factor Is Mediated by an Allosteric Transition in the RUNT Domain and by DNA Bending, Structure, vol.10, issue.10, pp.1395-1407, 2002. ,
DOI : 10.1016/S0969-2126(02)00853-5
Resolving embryonic blood cell fate choice in Drosophila: interplay of GCM and RUNX factors, Development, vol.143, issue.1, pp.4635-4644, 2005. ,
DOI : 10.1242/dev.133835
, , 1996.
, Genetic analysis of the lozenge gene complex in Drosophila melanogaster: adult visual system phenotypes, J Neurogenet, vol.10, pp.193-220
Alternative Runx1 promoter usage in mouse developmental hematopoiesis, Blood Cells, Molecules, and Diseases, vol.43, issue.1, pp.35-42, 2009. ,
DOI : 10.1016/j.bcmd.2009.03.011
Inducible chromatin priming is associated with the establishment of immunological memory in T cells, The EMBO Journal, vol.35, issue.5, 2016. ,
DOI : 10.15252/embj.201592534
, EMBO J, vol.35, pp.515-535
Crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger, Journal of Cell Science, vol.120, issue.7, pp.1209-1215, 2007. ,
DOI : 10.1242/jcs.03420
URL : http://jcs.biologists.org/content/joces/120/7/1209.full.pdf
Phosphorylation of AML1/RUNX1 Regulates Its Degradation and Nuclear Matrix Association, Molecular Cancer Research, vol.3, issue.7, pp.391-401, 2005. ,
DOI : 10.1158/1541-7786.MCR-04-0184
URL : http://mcr.aacrjournals.org/content/molcanres/3/7/391.full.pdf
AML1/RUNX1 Phosphorylation by Cyclin-Dependent Kinases Regulates the Degradation of AML1/RUNX1 by the Anaphase-Promoting Complex, Molecular and Cellular Biology, vol.26, issue.20, pp.7420-7429, 2006. ,
DOI : 10.1128/MCB.00597-06
Genome-Wide Screen for Modifiers of Ataxin-3 Neurodegeneration in Drosophila, PLoS Genetics, vol.36, issue.10, p.177, 2007. ,
DOI : 10.1371/journal.pgen.0030177.st003
Runx2 in normal tissues and cancer cells: A developing story, Blood Cells, Molecules, and Diseases, vol.45, issue.2, pp.117-123, 2010. ,
DOI : 10.1016/j.bcmd.2010.05.007
, , 2006.
, Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase, J Clin Invest, vol.116, pp.1410-1424
Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis, Proceedings of the National Academy of Sciences, vol.149, issue.12, pp.4986-4991, 2012. ,
DOI : 10.1002/ajmg.a.33021
Hemocyte-Secreted Type IV Collagen Enhances BMP Signaling to Guide Renal Tubule Morphogenesis in Drosophila, Developmental Cell, vol.19, issue.2, pp.296-306, 2010. ,
DOI : 10.1016/j.devcel.2010.07.019
, , 2000.
, Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo, Immunity, vol.13, pp.423-431
In vivo analysis of a developmental circuit for direct transcriptional activation and repression in the same cell by a Runx protein, Genes & Development, vol.17, issue.7, pp.838-843, 2003. ,
DOI : 10.1101/gad.1064803
Runt and Lozenge function in Drosophila development, Seminars in Cell & Developmental Biology, vol.11, issue.5, pp.327-336, 2000. ,
DOI : 10.1006/scdb.2000.0185
Transcriptional regulation of erythropoiesis: an affair involving multiple partners, Oncogene, vol.21, issue.21, pp.3368-3376, 2002. ,
DOI : 10.1101/gad.4.11.1886
URL : https://www.nature.com/articles/1205326.pdf
Models of haematopoiesis: seeing the wood for the trees, Nature Reviews Immunology, vol.9, issue.4, pp.293-300, 2009. ,
DOI : 10.1128/MCB.10.6.2703
Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells, Experimental Hematology, vol.38, issue.5, 2010. ,
DOI : 10.1016/j.exphem.2010.02.011
URL : http://europepmc.org/articles/pmc2854264?pdf=render
, Exp Hematol, vol.38, pp.403-416
Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila, Human Molecular Genetics, vol.9, issue.19, pp.2811-2820, 2000. ,
DOI : 10.1093/hmg/9.19.2811
Structure, function and evolution of DnaJ: conservation and adaptation of chaperone function, Cell Stress & Chaperones, vol.3, issue.1, pp.28-36, 1998. ,
DOI : 10.1379/1466-1268(1998)003<0028:SFAEOD>2.3.CO;2
Genomic profiling of 766 cancer-related genes in archived esophageal normal and carcinoma tissues, International Journal of Cancer, vol.92, issue.Suppl, pp.2249-2254, 2008. ,
DOI : 10.1002/ijc.23397
Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter, Nature, vol.93, issue.7231, pp.887-891, 2009. ,
DOI : 10.1038/nature07619
URL : http://europepmc.org/articles/pmc2744041?pdf=render
Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases, Oncogene, vol.12, issue.23, pp.2595-2609, 2011. ,
DOI : 10.1101/gad.12.15.2424
URL : http://www.nature.com/onc/journal/v30/n23/pdf/onc2010646a.pdf
Loss of Hspa9b in zebrafish recapitulates the ineffective hematopoiesis of the myelodysplastic syndrome, Blood, vol.105, issue.9, pp.3528-3534, 2005. ,
DOI : 10.1182/blood-2004-03-1089
Drosophila: a model for studying genetic and molecular aspects of haematopoiesis and associated leukaemias, Disease Models & Mechanisms, vol.4, issue.4, pp.439-445, 2011. ,
DOI : 10.1242/dmm.007351
URL : http://dmm.biologists.org/content/dmm/4/4/439.full.pdf
Cellular Immune Response to Parasitization in Drosophila Requires the EBF Orthologue Collier, PLoS Biology, vol.15, issue.8, p.196, 2004. ,
DOI : 10.1371/journal.pbio.0020196.t001
URL : https://hal.archives-ouvertes.fr/hal-00169831
Ontogeny of the Hematopoietic System, Annual Review of Immunology, vol.25, issue.1, pp.745-785, 2007. ,
DOI : 10.1146/annurev.immunol.25.022106.141538
URL : https://hal.archives-ouvertes.fr/pasteur-00362028
ERdj5, an Endoplasmic Reticulum (ER)-resident Protein Containing DnaJ and Thioredoxin Domains, Is Expressed in Secretory Cells or following ER Stress, Journal of Biological Chemistry, vol.19, issue.2, pp.1059-1066, 2003. ,
DOI : 10.1038/35000090
URL : http://www.jbc.org/content/278/2/1059.full.pdf
Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1., Genes & Development, vol.10, issue.10, pp.1194-1205, 1996. ,
DOI : 10.1101/gad.10.10.1194
, , 2014.
, Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling, Proc Natl Acad Sci U S A, vol.111, pp.8838-8843
, De Braekeleer M, 2011.
, RUNX1 translocations and fusion genes in malignant hemopathies, Future Oncol, vol.7, pp.77-91
Runx transcription factors in the development and function of the definitive hematopoietic system, Blood, vol.129, issue.15, pp.2061-2069, 2017. ,
DOI : 10.1182/blood-2016-12-689109
???Acute myeloid leukemia: a comprehensive review and 2016 update???, Blood Cancer Journal, vol.96, issue.7, p.441, 2016. ,
DOI : 10.1182/blood-2014-11-612721
Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1, Nature, vol.401, issue.6752, pp.489-493, 1999. ,
DOI : 10.1038/46809
The Tumor Suppressor hTid1 Inhibits STAT5b Activity via Functional Interaction, Journal of Biological Chemistry, vol.73, issue.7, pp.5034-5042, 2011. ,
DOI : 10.1038/onc.2009.413
Chaperones increase association of tau protein with microtubules, Proceedings of the National Academy of Sciences, vol.114, issue.13, pp.721-726, 2003. ,
DOI : 10.1083/jcb.145.2.265
An AML1/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the (8;21)(q22;q22) translocation, Blood, vol.81, pp.2860-2865, 1993. ,
Protein rescue from aggregates by powerful molecular chaperone machines, Nature Reviews Molecular Cell Biology, vol.3, issue.10, pp.617-629, 2013. ,
DOI : 10.1073/pnas.0510496103
Drosophila innate immunity: regional and functional specialization of prophenoloxidases, BMC Biology, vol.14, issue.1, p.81, 2015. ,
DOI : 10.1016/0263-7855(96)00018-5
Notch Signaling Controls Lineage Specification during Drosophila Larval Hematopoiesis, Current Biology, vol.12, issue.22, pp.1923-1927, 2002. ,
DOI : 10.1016/S0960-9822(02)01297-6
URL : https://hal.archives-ouvertes.fr/hal-00311259
Myeloid Leukemia Factor Acts in a Chaperone Complex to Regulate Transcription Factor Stability and Gene Expression, Journal of Molecular Biology, vol.429, issue.13, pp.2093-2107, 2016. ,
DOI : 10.1016/j.jmb.2016.10.026
Embryonic Beginnings of Definitive Hematopoietic Stem Cells, Annals of the New York Academy of Sciences, vol.89, issue.1 HEMATOPOIETIC, pp.256-262, 1999. ,
DOI : 10.1016/S1074-7613(00)80355-6
Of lineage and legacy: the development of mammalian hematopoietic stem cells, Nature Immunology, vol.1, issue.2, pp.129-136, 2008. ,
DOI : 10.1038/nature05725
The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells, The Journal of Experimental Medicine, vol.2, issue.8, pp.1945-1957, 2007. ,
DOI : 10.1016/j.immuni.2005.03.011
RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation, Blood, vol.101, issue.11, pp.4333-4341, 2003. ,
DOI : 10.1182/blood-2002-09-2708
URL : http://www.bloodjournal.org/content/bloodjournal/101/11/4333.full.pdf
Role and Importance of Phenoloxidase in Insect Hemostasis, Journal of Innate Immunity, vol.3, issue.1, pp.28-33, 2011. ,
DOI : 10.1159/000321931
Ubiquitin-independent proteasomal degradation, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1843, issue.1, pp.216-221, 2014. ,
DOI : 10.1016/j.bbamcr.2013.05.008
URL : https://doi.org/10.1016/j.bbamcr.2013.05.008
Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, 1992. ,
with similarity to Drosophila segmentation gene, runt, Blood, vol.80, pp.1825-1831 ,
Thicker Than Blood, Developmental Cell, vol.5, issue.5, pp.673-690, 2003. ,
DOI : 10.1016/S1534-5807(03)00335-6
Drosophila blood cell chemotaxis, Current Opinion in Cell Biology, vol.30, pp.1-8, 2014. ,
DOI : 10.1016/j.ceb.2014.04.002
URL : https://doi.org/10.1016/j.ceb.2014.04.002
, Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias, 2007.
, Haematologica, vol.92, pp.519-532
A Drosophila ortholog of the human MRJ modulates polyglutamine toxicity and aggregation, Neurobiology of Disease, vol.24, issue.2, pp.226-244, 2006. ,
DOI : 10.1016/j.nbd.2006.06.015
Yorkie and Scalloped Signaling Regulates Notch-Dependent Lineage Specification during Drosophila Hematopoiesis, Current Biology, vol.24, issue.22, pp.2665-2672, 2014. ,
DOI : 10.1016/j.cub.2014.09.081
Kicking it up a Notch for the best in show: Scalloped leads Yorkie into the haematopoietic arena, Fly, vol.163, issue.4, pp.206-217, 2014. ,
DOI : 10.7554/eLife.06166
A GATA/RUNX cis-regulatory module couples Drosophila blood cell commitment and differentiation into crystal cells, Developmental Biology, vol.305, issue.2, pp.726-734, 2007. ,
DOI : 10.1016/j.ydbio.2007.03.010
URL : https://hal.archives-ouvertes.fr/hal-00170567
Identification of genes that modify ataxin-1-induced neurodegeneration, Nature, vol.408, pp.101-106, 2000. ,
URL : https://hal.archives-ouvertes.fr/hal-02333201
Chaperone-Mediated Protein Folding, Physiological Reviews, vol.260, issue.2, pp.425-449, 1999. ,
DOI : 10.1074/jbc.270.18.10412
Lozenge is expressed in pluripotent precursor cells and patterns multiple cell types in the Drosophila eye through the control of cellspecific transcription factors, Development, vol.125, pp.3681-3687, 1998. ,
, , 2016.
, Extracellular reactive oxygen species drive apoptosis-induced proliferation via Drosophila macrophages, Curr Biol, vol.26, pp.575-584
Combinatorial interactions of Serpent, Lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis, Proceedings of the National Academy of Sciences, vol.93, issue.9, pp.11451-11456, 2003. ,
DOI : 10.1093/emboj/cdf545
Over-expression of a novel nuclear interactor of Suppressor of fused, the Drosophila myelodysplasia/myeloid leukaemia factor, induces abnormal morphogenesis associated with increased apoptosis and DNA synthesis, Genes to Cells, vol.12, issue.11, pp.897-911, 2003. ,
DOI : 10.1046/j.1365-2443.2001.00473.x
Croquemort, A Novel Drosophila Hemocyte/Macrophage Receptor that Recognizes Apoptotic Cells, Immunity, vol.4, issue.5, pp.431-443, 1996. ,
DOI : 10.1016/S1074-7613(00)80410-0
The Pax2 homolog sparkling is required for development of cone and pigment cells in the Drosophila??eye, Genes & Development, vol.11, issue.16, pp.2066-2078, 1997. ,
DOI : 10.1101/gad.11.16.2066
Aberrant Recruitment of the Nuclear Receptor Corepressor-Histone Deacetylase Complex by the Acute Myeloid Leukemia Fusion Partner ETO, Molecular and Cellular Biology, vol.18, issue.12, pp.7185-7191, 1998. ,
DOI : 10.1128/MCB.18.12.7185
Active Hematopoietic Hubs in Drosophila Adults Generate Hemocytes and Contribute to Immune Response, Developmental Cell, vol.33, issue.4, pp.478-488, 2015. ,
DOI : 10.1016/j.devcel.2015.03.014
Myeloid leukemia factor, Transcription, vol.12, issue.5, pp.250-254, 2012. ,
DOI : 10.1002/jcb.22157
, Molecular and Cellular Biology, vol.30, issue.11, pp.2837-2848, 2010.
DOI : 10.1128/MCB.01625-09
, Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia, 1995.
, Proc Natl Acad Sci U S A, vol.92, pp.4917-4921
Posttranslational modifications of RUNX1 as potential anticancer targets, Oncogene, vol.1835, issue.27, pp.3483-3492, 2015. ,
DOI : 10.4049/jimmunol.174.6.3526
Phosphorylation of RUNX1 by Cyclin-dependent Kinase Reduces Direct Interaction with HDAC1 and HDAC3, Journal of Biological Chemistry, vol.83, issue.1, pp.208-215, 2011. ,
DOI : 10.1038/sj.onc.1209591
A DNAJB Chaperone Subfamily with HDAC-Dependent Activities Suppresses Toxic Protein Aggregation, Molecular Cell, vol.37, issue.3, pp.355-369, 2010. ,
DOI : 10.1016/j.molcel.2010.01.001
cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP, Oncogene, vol.23, issue.20, 2004. ,
DOI : 10.1038/sj.onc.1202711
, Oncogene, vol.23, pp.3700-3707
Core binding factor genes and human leukemia, Haematologica, vol.87, pp.1307-1323, 2002. ,
Blood Cells and Blood Cell Development in the Animal Kingdom, Annual Review of Cell and Developmental Biology, vol.22, issue.1, pp.677-712, 2006. ,
DOI : 10.1146/annurev.cellbio.22.010605.093317
Molecular chaperones in protein folding and proteostasis, Nature, vol.323, issue.7356, pp.324-332, 2011. ,
DOI : 10.1126/science.1165946
, , 2009.
, Identification of lipoteichoic acid as a ligand for Draper in the phagocytosis of Staphylococcus aureus by Drosophila hemocytes, J Immunol, vol.183, pp.7451-7460
Dual Bar homeo box genes of Drosophila required in two photoreceptor cells, R1 and R6, and primary pigment cells for normal eye development., Genes & Development, vol.6, issue.1, pp.50-60, 1992. ,
DOI : 10.1101/gad.6.1.50
Phagocytic ability declines with age in adult Drosophila hemocytes, Aging Cell, vol.176, issue.4, pp.719-728, 2014. ,
DOI : 10.1534/genetics.106.066761
Heat shock protein 70, 2006. ,
, inhibits ?-synuclein fibril formation via interactions with diverse intermediates, J Mol Biol, vol.364, pp.323-336
Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation, The EMBO Journal, vol.20, issue.4, pp.723-733, 2001. ,
DOI : 10.1093/emboj/20.4.723
A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation, Genes & Development, vol.26, issue.14, 2012. ,
DOI : 10.1101/gad.192054.112
, Genes Dev, vol.26, pp.1587-1601
Visualization of protein interactions in living Drosophila embryos by the bimolecular fluorescence complementation assay, BMC Biology, vol.9, issue.1, 2011. ,
DOI : 10.1186/1741-7007-9-5
URL : https://hal.archives-ouvertes.fr/hal-00848904
AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis, Nature Medicine, vol.46, issue.3, pp.299-304, 2004. ,
DOI : 10.1016/S0091-679X(08)61925-1
TLE, the Human Homolog of Groucho, Interacts with AML1 and Acts as a Repressor of AML1-Induced Transactivation, Biochemical and Biophysical Research Communications, vol.252, issue.3, pp.582-589, 1998. ,
DOI : 10.1006/bbrc.1998.9705
The Corepressor mSin3A Regulates Phosphorylation-Induced Activation, Intranuclear Location, and Stability of AML1, Molecular and Cellular Biology, vol.24, issue.3, pp.1033-1043, 2004. ,
DOI : 10.1128/MCB.24.3.1033-1043.2004
Oncogenic potential of the RUNX gene family: ???Overview???, Oncogene, vol.23, issue.24, pp.4198-4208, 2004. ,
DOI : 10.1073/pnas.180309597
Alternative splicing removes an Ets interaction domain from Lozenge during Drosophila eye development, Development Genes and Evolution, vol.14, issue.12, pp.423-435, 2005. ,
DOI : 10.1128/MCB.14.12.8051
Hematopoiesis, Development, vol.140, issue.12, pp.2463-2467, 2013. ,
DOI : 10.1242/dev.083147
Localization of RNA polymerase in polytene chromosomes of Drosophila melanogaster., Proceedings of the National Academy of Sciences, vol.74, issue.5, pp.2079-2083, 1977. ,
DOI : 10.1073/pnas.74.5.2079
Redundant function of Runt domain binding partners, Big brother and Brother, during Drosophila development, Development, vol.128, pp.2639-2648, 2001. ,
The HSP70 chaperone machinery: J proteins as drivers of functional specificity, Nature Reviews Molecular Cell Biology, vol.281, issue.8, pp.579-592, 2010. ,
DOI : 10.1128/MCB.19.6.4535
Genetic Suppression of Polyglutamine Toxicity in Drosophila, Science, vol.287, issue.5459, pp.1837-1840, 2000. ,
DOI : 10.1126/science.287.5459.1837
, Annual Review of Genomics and Human Genetics, vol.3, issue.1, pp.179-198, 2002.
DOI : 10.1146/annurev.genom.3.032802.115046
Abstract, Biological Chemistry, vol.20, issue.5, pp.481-489, 2010. ,
DOI : 10.1126/science.8310297
RUNX family members are covalently modified and regulated by PIAS1-mediated sumoylation, Oncogenesis, vol.15, issue.4, p.101, 2014. ,
DOI : 10.1038/nrc1607
Evidence for sequestration of polyglutamine inclusions by Drosophila myeloid leukemia factor, Molecular and Cellular Neuroscience, vol.29, issue.4, pp.536-544, 2005. ,
DOI : 10.1016/j.mcn.2005.04.005
Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains, The EMBO Journal, vol.18, issue.6, 1999. ,
DOI : 10.1093/emboj/18.6.1609
, EMBO J, vol.18, pp.1609-1620
Molecular Chaperone Functions in Protein Folding and Proteostasis, Annual Review of Biochemistry, vol.82, issue.1, pp.323-355, 2013. ,
DOI : 10.1146/annurev-biochem-060208-092442
Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation, The EMBO Journal, vol.17, issue.11, pp.2994-3004, 1998. ,
DOI : 10.1093/emboj/17.11.2994
Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein, The EMBO Journal, vol.20, issue.24, pp.7184-7196, 2001. ,
DOI : 10.1093/emboj/20.24.7184
Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila, Cell, vol.123, issue.2, pp.335-346, 2005. ,
DOI : 10.1016/j.cell.2005.08.034
MiR144/451 expression is repressed by RUNX1 furing megakaryopoiesis and disturbed by RUNX1/ETO, PLoS Genet, vol.12, 2016. ,
J protein mutations and resulting proteostasis collapse, Frontiers in Cellular Neuroscience, vol.263, 0191. ,
DOI : 10.1126/science.8310297
Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre, Nature, vol.126, issue.7133, pp.325-328, 2007. ,
DOI : 10.1038/nature05650
URL : https://hal.archives-ouvertes.fr/hal-00169818
, , 1996.
, cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2), Genomics, vol.35, pp.392-396
Asrij maintains the stem cell niche and controls differentiation during Drosophila lymph gland hematopoiesis, PLoS One, vol.6, 2011. ,
Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110, Cell Death & Disease, vol.15, issue.10, p.833, 2013. ,
DOI : 10.1093/emboj/20.3.499
, , 2007.
, Nimrod, a putative phagocytosis receptor with EGF repeats in Drosophila plasmatocytes, Curr Biol, vol.17, pp.649-654
RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation, Blood, vol.125, issue.23, pp.3570-3579, 2015. ,
DOI : 10.1182/blood-2014-11-610519
URL : http://www.bloodjournal.org/content/bloodjournal/125/23/3570.full.pdf
Hemangioblast, hemogenic endothelium, and primitive versus definitive hematopoiesis, Experimental Hematology, vol.49, pp.19-24, 2017. ,
DOI : 10.1016/j.exphem.2016.12.009
URL : https://www.research.manchester.ac.uk/portal/files/50449107/Lacaud_Kouskoff_ISEH_perspective_revised.pdf
, , 2001.
, Dev Biol, vol.230, pp.243-257
Specification of Drosophila Hematopoietic Lineage by Conserved Transcription Factors, Science, vol.288, issue.5463, pp.146-149, 2000. ,
DOI : 10.1126/science.288.5463.146
A Serrate-expressing signaling center controls Drosophila hematopoiesis, Genes & Development, vol.17, issue.3, pp.348-353, 2003. ,
DOI : 10.1101/gad.1052803
URL : http://genesdev.cshlp.org/content/17/3/348.full.pdf
NPM-MLF1 synergizes with Npm haploinsufficiency to enhance myeloid progenitor activity, Leukemia, vol.23, issue.5, pp.1110-1112, 2012. ,
DOI : 10.1038/leu.2008.326
URL : https://www.nature.com/articles/leu2011365.pdf
Author response, eLife, vol.101, p.6166, 2015. ,
DOI : 10.7554/eLife.06166.021
hematopoiesis under normal conditions and in response to immune stress, FEBS Letters, vol.125, issue.Pt 1, pp.4034-4051, 2016. ,
DOI : 10.1182/blood-2014-05-577940
URL : https://hal.archives-ouvertes.fr/hal-01920861
Architecture and anatomy of the genomic locus encoding the human leukemia-associated transcription factor RUNX1/AML1, Gene, vol.262, issue.1-2, pp.23-33, 2001. ,
DOI : 10.1016/S0378-1119(00)00532-1
Differential interactions between Brother proteins and Runt domain proteins in the Drosophila embryo and eye, Development, vol.126, pp.3313-3322, 1999. ,
Genome-wide studies identify a novel interplay between AML1 and AML1/ETO in t(8;21) acute myeloid leukemia, Blood, vol.127, issue.2, pp.233-242, 2016. ,
DOI : 10.1182/blood-2015-03-626671
RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis, The EMBO Journal, vol.148, issue.22, pp.4318-4333, 2012. ,
DOI : 10.1016/j.cell.2011.11.058
RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence, Blood, vol.124, issue.11, pp.11-20, 2014. ,
DOI : 10.1182/blood-2014-04-572958
, , 2002.
, MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1, J Biol Chem, vol.277, pp.40997-41008
Overexpression of an isoform of AML1 in acute leukemia and its potential role in leukemogenesis, Leukemia, vol.55, issue.4, pp.739-745, 2009. ,
DOI : 10.1371/journal.pmed.0040172
Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expression, Blood, vol.103, issue.7, pp.2522-2529, 2004. ,
DOI : 10.1182/blood-2003-07-2439
Runx3 at the interface of immunity, inflammation and cancer, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol.1855, issue.2, pp.131-143, 2015. ,
DOI : 10.1016/j.bbcan.2015.01.004
Acute Myeloid Leukemia, New England Journal of Medicine, vol.341, issue.14, pp.1051-1062, 1999. ,
DOI : 10.1056/NEJM199909303411407
Tid1 Isoforms Are Mitochondrial DnaJ-like Chaperones with Unique Carboxyl Termini That Determine Cytosolic Fate, Journal of Biological Chemistry, vol.8, issue.19, pp.13150-13158, 2006. ,
DOI : 10.1074/jbc.273.40.25587
URL : http://www.jbc.org/content/281/19/13150.full.pdf
Heat shock protein 70 inhibits the nuclear import of apoptosis-inducing factor to avoid DNA fragmentation in TF-1 cells during erythropoiesis, FEBS Letters, vol.10, issue.1, pp.109-117, 2007. ,
DOI : 10.1379/CSC-79R.1
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation, Gene, vol.245, issue.2, pp.223-235, 2000. ,
DOI : 10.1016/S0378-1119(00)00014-7
ETO, a Target of t(8;21) in Acute Leukemia, Interacts with the N-CoR and mSin3 Corepressors, Molecular and Cellular Biology, vol.18, issue.12, pp.7176-7184, 1998. ,
DOI : 10.1128/MCB.18.12.7176
The peripheral nervous system supports blood cell homing and survival in the Drosophila larva, Development, vol.138, issue.24, pp.5379-5391, 2011. ,
DOI : 10.1242/dev.067322
URL : http://dev.biologists.org/content/develop/138/24/5379.full.pdf
A Hedgehog- and Antennapedia-dependent niche maintains Drosophila haematopoietic precursors, Nature, vol.2, issue.7133, pp.320-324, 2007. ,
DOI : 10.1038/nature05585
URL : http://europepmc.org/articles/pmc2807630?pdf=render
Distinctive genotypes in infants with T-cell acute lymphoblastic leukaemia, British Journal of Haematology, vol.481, issue.4, pp.574-584, 2015. ,
DOI : 10.1038/nature10725
URL : http://onlinelibrary.wiley.com/doi/10.1111/bjh.13613/pdf
Modulation of Drosophila heat shock transcription factor activity by the molecular chaperone DROJ1, The EMBO Journal, vol.20, issue.3, pp.499-509, 2001. ,
DOI : 10.1093/emboj/20.3.499
URL : http://emboj.embopress.org/content/embojnl/20/3/499.full.pdf
Characterization of the Drosophila myeloid leukemia factor, Genes to Cells, vol.6, issue.12, pp.1317-1335, 2006. ,
DOI : 10.1111/j.1365-2443.2004.00775.x
, , 2000.
, Elevated MLF1 expression correlates with malignant progression from myelodysplastic syndrome, Leukemia, vol.14, pp.1757-1765
Model for Human Neurodegenerative Disease, Genetics, vol.201, issue.2, pp.377-402, 2015. ,
DOI : 10.1534/genetics.115.179457
The Hippo Pathway Regulates Hematopoiesis in Drosophila melanogaster, Current Biology, vol.24, issue.22, pp.2673-2680, 2014. ,
DOI : 10.1016/j.cub.2014.10.031
Zfrp8, the Drosophila ortholog of PDCD2, functions in lymph gland development and controls cell proliferation, Development, vol.134, issue.13, pp.2387-2396, 2007. ,
DOI : 10.1242/dev.003616
DNA binding modes of leukemia oncoproteins, Blood, vol.127, issue.2, pp.177-178, 2016. ,
DOI : 10.1182/blood-2015-11-681080
Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia, EMBO J, vol.13, pp.504-510, 1994. ,
, , 1993.
, translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript
, EMBO J, vol.12, pp.2715-2721
gene involved in acute myeloid leukemia, Nucleic Acids Research, vol.23, issue.14, pp.2762-2769, 1995. ,
DOI : 10.1093/nar/23.14.2762
t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1., Proceedings of the National Academy of Sciences, vol.88, issue.23, pp.10431-10434, 1991. ,
DOI : 10.1073/pnas.88.23.10431
The drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates, Cell, vol.60, issue.2, pp.211-224, 1990. ,
DOI : 10.1016/0092-8674(90)90737-Y
Dissecting stem cell differentiation using single cell expression profiling, Current Opinion in Cell Biology, vol.43, pp.78-86, 2016. ,
DOI : 10.1016/j.ceb.2016.08.005
Structural insights of the MLF1/14-3-3 interaction, FEBS Journal, vol.53, issue.4, pp.563-571, 2012. ,
DOI : 10.1107/S0907444996012255
URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2011.08445.x/pdf
The Heat Shock Response: Systems Biology of Proteotoxic Stress in Aging and Disease, Cold Spring Harbor Symposia on Quantitative Biology, vol.76, issue.0, pp.91-99, 2011. ,
DOI : 10.1101/sqb.2012.76.010637
The bone marrow niche for haematopoietic stem cells, Nature, vol.8, issue.7483, pp.327-334, 2014. ,
DOI : 10.1038/nri2279
URL : http://europepmc.org/articles/pmc4514480?pdf=render
calcium levels and inhibits cellular immunity, Proceedings of the National Academy of Sciences, vol.110, issue.23, pp.9427-9432, 2013. ,
DOI : 10.1073/pnas.0914191107
URL : http://www.pnas.org/content/110/23/9427.full.pdf
Modulation of neurodegeneration by molecular chaperones, Nature Reviews Neuroscience, vol.19, issue.1, 2005. ,
DOI : 10.1038/502
, Nat Rev Neurosci, vol.6, pp.11-22
Interaction Between Notch and Hif-?? in Development and Survival of Drosophila Blood Cells, Science, vol.112, issue.5, pp.1210-1213, 2011. ,
DOI : 10.1016/S0092-8674(03)00154-5
The AML1 Transcription Factor Functions to Develop and Maintain Hematogenic Precursor Cells in the Embryonic Aorta???Gonad???Mesonephros Region, Developmental Biology, vol.220, issue.1, pp.27-36, 2000. ,
DOI : 10.1006/dbio.2000.9617
Hematopoietic stem cell niche: An interplay among a repertoire of multiple functional niches, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1830, issue.2, pp.2404-2409, 2013. ,
DOI : 10.1016/j.bbagen.2012.08.023
Worming out the biology of Runx, Developmental Biology, vol.313, issue.2, pp.492-500, 2008. ,
DOI : 10.1016/j.ydbio.2007.11.002
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters, Development, vol.126, pp.2563-2575, 1999. ,
Runx1 Is Expressed in Adult Mouse Hematopoietic Stem Cells and Differentiating Myeloid and Lymphoid Cells, But Not in Maturing Erythroid Cells, Stem Cells, vol.22, issue.2, pp.158-168, 2004. ,
DOI : 10.1634/stemcells.22-2-158
Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations., Proceedings of the National Academy of Sciences, vol.91, issue.9, pp.4004-4008, 1994. ,
DOI : 10.1073/pnas.91.9.4004
Molecular Cloning and Characterization of PEBP2??, the Heterodimeric Partner of a Novel Drosophila runt-Related DNA Binding Protein PEBP2??, Virology, vol.194, issue.1, pp.314-331, 1993. ,
DOI : 10.1006/viro.1993.1262
, , 1993.
, PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene, PEBP2, pp.6859-6863
, , 2000.
, Characterization of a Drosophila homologue of the human myelodysplasia/myeloid leukemia factor (MLF), Gene, vol.260, pp.133-143
AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis, Cell, vol.84, issue.2, pp.321-330, 1996. ,
DOI : 10.1016/S0092-8674(00)80986-1
Diversification of haematopoietic stem cells to specific lineages, Nature Reviews Genetics, vol.112, issue.1, pp.57-64, 2000. ,
DOI : 10.1083/jcb.112.5.781
Hematopoiesis: An Evolving Paradigm for Stem Cell Biology, Cell, vol.132, issue.4, pp.631-644, 2008. ,
DOI : 10.1016/j.cell.2008.01.025
Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation, Nature, vol.422, issue.7263, pp.537-541, 2009. ,
DOI : 10.1038/nature08313
AML1???ETO downregulates the granulocytic differentiation factor C/EBP?? in t(8;21) myeloid leukemia, Nature Medicine, vol.89, issue.4, pp.444-451, 2001. ,
DOI : 10.1073/pnas.89.12.5547
Cell-Autonomous Function of Runx1 Transcriptionally Regulates Mouse Megakaryocytic Maturation, PLoS ONE, vol.151, issue.5, p.64248, 2013. ,
DOI : 10.1371/journal.pone.0064248.s002
Dynamic combinatorial interactions of RUNX1 and cooperating partners regulates megakaryocytic differentiation in cell line models, Blood, vol.117, issue.1, pp.1-14, 2011. ,
DOI : 10.1182/blood-2010-07-295113
The development and maintenance of resident macrophages, Nature Immunology, vol.14, issue.1, pp.2-8, 2016. ,
DOI : 10.1038/ni.2622
, , 2012.
, Bacteriophage-encoded J-domain protein interacts with the DnaK/Hsp70 chaperone and stabilizes the heat-shock factor ? 32 of Escherichia coli, PLoS Genet, vol.8, 1003037.
, , 1998.
, Multiple functional domains of AML1: PU.1 and C/EBP? synergize with different regions of AML1, Mol Cell Biol, vol.18, pp.3915-3925
Identification of a Dynamic Core Transcriptional Network in t(8;21) AML that Regulates Differentiation Block and Self-Renewal, Cell Reports, vol.8, issue.6, 1974. ,
DOI : 10.1016/j.celrep.2014.08.024
Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding, Leukemia, vol.26, issue.8, pp.1829-1841, 2012. ,
DOI : 10.1038/sj.onc.1210452
RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells, RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells, pp.2882-2890, 2013. ,
DOI : 10.1182/blood-2012-08-451641
Myeloid leukemia factor-1 is a novel modulator of neonatal rat cardiomyocyte proliferation, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1864, issue.4, pp.634-644, 2017. ,
DOI : 10.1016/j.bbamcr.2017.01.004
Drosophila immune cell migration and adhesion during embryonic development and larval immune responses, Current Opinion in Cell Biology, vol.36, pp.71-79, 2015. ,
DOI : 10.1016/j.ceb.2015.07.003
,
RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription, Oncogene, vol.25, pp.5777-5786, 2006. ,
A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila, Development, vol.122, pp.4023-4031, 1996. ,
The evolution of Runx genes I. A comparative study of sequences from phylogenetically diverse model organisms, BMC Evol Biol, vol.3, issue.4, 2003. ,
, , 2007.
, Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1, Nature, vol.445, pp.102-105
, , 2013.
, Endothelio-mesenchymal interaction controls runx1 expression and modulates the notch pathway to initiate aortic hematopoiesis, Dev Cell, vol.24, pp.600-611
The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion, Blood, vol.85, pp.3662-3770, 1995. ,
Chromosomes in Leukemia and Beyond: From Irrelevant to Central Players, Annual Review of Genomics and Human Genetics, vol.10, issue.1, 2009. ,
DOI : 10.1146/annurev-genom-082908-150144
, Annu Rev Genomics Hum Genet, vol.10, pp.1-18
Chaperone machines for protein folding, unfolding and disaggregation, Nature Reviews Molecular Cell Biology, vol.482, issue.10, pp.630-642, 2013. ,
DOI : 10.1016/S0092-8674(00)00166-5
URL : http://europepmc.org/articles/pmc4340576?pdf=render
Core-Binding Factor Acute Myeloid Leukemia, Archives of Pathology & Laboratory Medicine, vol.135, issue.11, pp.1504-1509, 2011. ,
DOI : 10.5858/arpa.2010-0482-RS
Runx1 and Cbf?? regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder, Blood, vol.123, issue.19, pp.2968-2977, 2014. ,
DOI : 10.1182/blood-2013-11-539643
The relationship between the spleen colony-forming cell and the haemopoietic stem cell, Blood cells, vol.4, pp.7-25, 1978. ,
Runx1???Cbf?? facilitates early B lymphocyte development by regulating expression of Ebf1, The Journal of Experimental Medicine, vol.209, issue.7, pp.1255-1262, 2012. ,
DOI : 10.1016/j.molimm.2003.11.031
URL : http://jem.rupress.org/content/jem/209/7/1255.full.pdf
, Biochemistry, vol.44, issue.5, pp.1683-1689, 2005.
DOI : 10.1021/bi0480943
CHIP functions an E3 ubiquitin ligase of Runx1, Biochemical and Biophysical Research Communications, vol.386, issue.1, pp.242-246, 2009. ,
DOI : 10.1016/j.bbrc.2009.06.043
PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential, Blood, vol.119, issue.21, pp.4953-4962, 2012. ,
DOI : 10.1182/blood-2011-04-347476
URL : http://www.bloodjournal.org/content/119/21/4953.full.pdf
Getting blood from bone: An emerging understanding of the role that osteoblasts play in regulating hematopoietic stem cells within their niche, Experimental Hematology, vol.40, issue.9, pp.685-694, 2012. ,
DOI : 10.1016/j.exphem.2012.05.004
Dual Role of Wingless Signaling in Stem-like Hematopoietic Precursor Maintenance in Drosophila, Developmental Cell, vol.16, issue.5, pp.756-763, 2009. ,
DOI : 10.1016/j.devcel.2009.03.003
Chromatin signatures at Notch-regulated enhancers reveal large-scale changes in H3K56ac upon activation, The EMBO Journal, vol.34, issue.14, 2015. ,
DOI : 10.15252/embj.201489923
URL : http://emboj.embopress.org/content/embojnl/34/14/1889.full.pdf
, EMBO J, vol.34, pp.1889-1904
, , 1999.
, Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia, Nat Genet, vol.23, pp.166-175
Role of RUNX1 in hematological malignancies, Blood, vol.129, issue.15, pp.2070-2082, 2017. ,
DOI : 10.1182/blood-2016-10-687830
Core-binding factors in haematopoiesis and leukaemia, Nature Reviews Cancer, vol.11, issue.7, pp.502-513, 2002. ,
DOI : 10.1006/scdb.2000.0186
The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis, Blood, vol.114, issue.26, pp.5279-5289, 2009. ,
DOI : 10.1182/blood-2009-05-222307
Human DNAJ in cancer and stem cells, Cancer Letters, vol.312, issue.2, pp.129-142, 2011. ,
DOI : 10.1016/j.canlet.2011.08.019
Identification of Novel Nuclear Localization Signals of Drosophila Myeloid Leukemia Factor, Cell Structure and Function, vol.32, issue.2, pp.163-169, 2007. ,
DOI : 10.1247/csf.07039
Identification of differentially expressed genes in human lung squamous cell carcinoma using suppression subtractive hybridization, Cancer Letters, vol.212, issue.1, pp.83-93, 2004. ,
DOI : 10.1016/j.canlet.2004.03.023
MLF1 is a proapoptotic antagonist of HOP complex-mediated survival, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1864, issue.4, pp.719-727, 2017. ,
DOI : 10.1016/j.bbamcr.2017.01.016
Myeloid leukemia factor 1 interfered with Bcl-XL to promote apoptosis and its function was regulated by 14-3-3, Journal of Physiology and Biochemistry, vol.15, issue.12, pp.807-821, 2015. ,
DOI : 10.1101/gad.897601
, , 2001.
, Structural analyses of DNA recognition by the AML1/Runx-1 runt domain and its allosteric control by CBF?, Cell, vol.104, pp.755-767
A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways, Cell, vol.158, issue.2, pp.434-448, 2014. ,
DOI : 10.1016/j.cell.2014.05.039
The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability., Molecular and Cellular Biology, vol.16, issue.7, pp.3967-3979, 1996. ,
DOI : 10.1128/MCB.16.7.3967
Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development, Cell, vol.111, issue.5, pp.621-633, 2002. ,
DOI : 10.1016/S0092-8674(02)01111-X
Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme, Development, vol.140, issue.4, pp.926-937, 2013. ,
DOI : 10.1242/dev.086785
Genome-wide Analysis of Simultaneous GATA1/2, RUNX1, FLI1, and SCL Binding in Megakaryocytes Identifies Hematopoietic Regulators, Developmental Cell, vol.20, issue.5, pp.597-609, 2011. ,
DOI : 10.1016/j.devcel.2011.04.008
Expansion of functionally defined mouse hematopoietic stem and progenitor cells by a short isoform of RUNX1/AML1, Blood, vol.119, issue.3, pp.727-735, 2012. ,
DOI : 10.1182/blood-2011-06-362277
Isoform-Specific Potentiation of Stem and Progenitor Cell Engraftment by AML1/RUNX1, PLoS Medicine, vol.106, issue.5, p.172, 2007. ,
DOI : 10.1371/journal.pmed.0040172.sg002
,
Runx1 transcription factor is required for myoblasts proliferation during muscle regeneration, PLoS Genet, vol.11, 2015. ,
The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress, Nature, vol.397, issue.7504, pp.268-272, 2014. ,
DOI : 10.1038/16729
A Novel Complex, RUNX1-MYEF2, Represses Hematopoietic Genes in Erythroid Cells, Molecular and Cellular Biology, vol.32, issue.19, pp.3814-3822, 2012. ,
DOI : 10.1128/MCB.05938-11
, , 2004.
, Nomenclature for Runt-related (RUNX) proteins, Oncogene, vol.23, pp.4209-4210
, , 2015.
, Companion blood cells control ovarian stem cell niche microenvironment and homeostasis, Cell Rep, vol.13, pp.546-560
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia, Blood, vol.101, issue.1, pp.270-277, 2003. ,
DOI : 10.1182/blood-2002-04-1288
, Biochemistry, vol.47, issue.27, pp.7001-7011, 2008.
DOI : 10.1021/bi800639z
PRMT4 Blocks Myeloid Differentiation by Assembling a Methyl-RUNX1-Dependent Repressor Complex, Cell Reports, vol.5, issue.6, pp.1625-1638, 2013. ,
DOI : 10.1016/j.celrep.2013.11.025
Cooperation between the GATA and RUNX factors Serpent and Lozenge during Drosophila hematopoiesis, The EMBO Journal, vol.94, issue.24, pp.6516-6525, 2003. ,
DOI : 10.1016/S0092-8674(00)00107-0
URL : https://hal.archives-ouvertes.fr/hal-00170569
ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human, 1998. ,
, Proc Natl Acad Sci U S A, vol.95, pp.10860-10865
, , 2010.
, Proximity ligation assays: a recent addition to the proteomics toolbox, Expert Rev Proteomics, vol.7, pp.401-409
Chaperoning erythropoiesis, Blood, vol.113, issue.10, pp.2136-2144, 2009. ,
DOI : 10.1182/blood-2008-09-115238
The t(8;21) translocation converts AML1 into a constitutive transcriptional repressor, Development, vol.132, issue.10, pp.2263-2272, 2005. ,
DOI : 10.1242/dev.01824
Lozenge directly activates argos and klumpfuss to regulate programmed cell death, Genes & Development, vol.19, issue.9, pp.1034-1039, 2005. ,
DOI : 10.1101/gad.1298105
, , 1999.
, HLS7, a hemopoietic lineage switch gene homologous to the leukemia-inducing gene MLF1
, EMBO J, vol.18, pp.5559-5566
Myeloid Leukemia Factor 1 Associates with a Novel Heterogeneous Nuclear Ribonucleoprotein U-like Molecule, Journal of Biological Chemistry, vol.127, issue.50, pp.38791-38800, 2006. ,
DOI : 10.1128/MCB.20.20.7480-7489.2000
Myeloid Leukemia Factor 1 inhibits erythropoietin-induced differentiation, 2004. ,
, Oncogene, vol.23, pp.5105-5109
, , 2015.
, Macrophage-derived upd3 cytokine causes impaired glucose homeostasis and reduced lifespan in Drosophila fed a lipid-rich diet, Immunity, vol.42, pp.133-144
Detection of functional haematopoietic stem cell niche using real-time imaging, Nature, vol.156, issue.7225, pp.97-101, 2009. ,
DOI : 10.1016/j.cell.2005.10.041
AML1 Is Functionally Regulated through p300-mediated Acetylation on Specific Lysine Residues, Journal of Biological Chemistry, vol.19, issue.15, pp.15630-15638, 2004. ,
DOI : 10.1038/35042612
Drosophila myeloid leukemia factor acts with DREF to activate the JNK signaling pathway, Oncogenesis, vol.24, issue.4, p.98, 2014. ,
DOI : 10.1074/jbc.274.49.35080
URL : https://hal.archives-ouvertes.fr/hal-00995019
Genetic analysis of two genes, dnaJ and dnaK, necessary for Escherichia coli and bacteriophage lambda DNA replication, MGG Molecular & General Genetics, vol.25, issue.1, pp.9-14, 1978. ,
DOI : 10.1007/BF00267593
Runx1 is involved in primitive erythropoiesis in the mouse, Blood, vol.111, issue.8, pp.4075-4080, 2008. ,
DOI : 10.1182/blood-2007-05-091637
, , 2001.
, Requirement of Runx1/AML1/PEBP2?B for the generation of haematopoietic cells from endothelial cells, Genes Cells, vol.6, pp.13-23
The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, Oncogene, vol.12, pp.1-265, 1996. ,
Shuttling Imbalance of MLF1 Results in p53 Instability and Increases Susceptibility to Oncogenic Transformation, Molecular and Cellular Biology, vol.28, issue.1, pp.422-434, 2008. ,
DOI : 10.1128/MCB.02335-06
Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3, The EMBO Journal, vol.826, issue.9, pp.1739-1749, 2005. ,
DOI : 10.1038/sj.emboj.7600656
Caspase Activation Is Required for Terminal Erythroid Differentiation, The Journal of Experimental Medicine, vol.112, issue.2, pp.247-254, 2001. ,
DOI : 10.1084/jem.190.12.1725
, , 1996.
, CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF?2) synergistically activate the macrophage colony-stimulating factor receptor promoter, Mol Cell Biol, vol.16, pp.1231-1240
Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation, Blood, vol.111, issue.3, pp.1193-1200, 2008. ,
DOI : 10.1182/blood-2007-08-109702
URL : http://www.bloodjournal.org/content/bloodjournal/111/3/1193.full.pdf
Phorbol Ester Treatment of K562 Cells Regulates the Transcriptional Activity of AML1c through Phosphorylation, Journal of Biological Chemistry, vol.9, issue.51, pp.53116-53125, 2004. ,
DOI : 10.1093/embo-reports/kvf193
URL : http://www.jbc.org/content/279/51/53116.full.pdf
Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity, Genes & Development, vol.22, issue.5, pp.640-653, 2008. ,
DOI : 10.1101/gad.1632608
URL : http://genesdev.cshlp.org/content/22/5/640.full.pdf