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Cateslytin and Chromofungin, two CgA derived peptides actors of the immune and cardiac systems

Abstract : CgA is a pro-hormone costored in secretory granules and numerous cleavage products of this protein have been identified. Chromofungin (Chr: CgA47-66) and Cateslytin (Ctl: CgA344–358) are peptides that display antimicrobial activities.Staphylococcus aureus is an opportunistic pathogen and the leading cause of a wide range of severe clinical infections and one of the most important cause of hospital-acquired infections and leading infective cause of destruction of endocardial tissue after implantation of prosthetic heart valve. The first part of the study, we found that Chr induced negative inotropic effects without changing coronary pressure. The AKT/eNOS/cGMP/PKG pathway mediated this action. We also found that Chr acted as a postconditioning agent against ischemia/reperfusion damages. Cardioprotection involved PI3K, RISK pathway, MitoKATPand miRNA-21. In order to develop a new coating of cardiac valves, the peptide D*T *Ctl proves to be useful under non-oxidizing conditions because (1) it exhibits antimicrobial activity against S. aureus; (2) in the presence of S. aureus, it allows proteolytic cleavage to release the active Ct1 peptide.In the last part of this thesis we showed in vivo the antibacterial role of Ctl against S. aureus infection at the systemic and cardiac levels, but also its cardioprotective action.
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Submitted on : Tuesday, June 12, 2018 - 5:29:05 PM
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  • HAL Id : tel-01814011, version 1



Francesco Scavello. Cateslytin and Chromofungin, two CgA derived peptides actors of the immune and cardiac systems. Chemical Physics [physics.chem-ph]. Université de Strasbourg, 2017. English. ⟨NNT : 2017STRAE035⟩. ⟨tel-01814011⟩



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