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Etude des premiers évènements d'infection par le VIH-1 dans les tissus du tractus génital féminin : inhibition par les anticorps

Abstract : During intercourse, HIV free virus particles and cell-associated virus, penetrate into the female genital mucosa. The first events following HIV transmission in tissues are still controversial. In order to analyze these first events of transmission, two different models were developed during my thesis: a heterologous model of HIV transmission with cells generated from blood and a model with cells isolated from cervico-vaginal tissues. We found that dendritic cells are preferentially infected. Moreover, neutralizing antibodies efficiently inhibit these first events of HIV transmission. Future HIV prophylactic vaccine design should take into account the potential infection of dendritic cells and new strategies should be developed to prevent the infection of these particular cell populations.
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https://tel.archives-ouvertes.fr/tel-01813438
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Submitted on : Tuesday, June 12, 2018 - 1:29:05 PM
Last modification on : Friday, October 23, 2020 - 5:02:18 PM
Long-term archiving on: : Thursday, September 13, 2018 - 7:02:00 PM

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Ducloy_Camille_2017_ED414.pdf
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  • HAL Id : tel-01813438, version 1

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Camille Ducloy. Etude des premiers évènements d'infection par le VIH-1 dans les tissus du tractus génital féminin : inhibition par les anticorps. Virologie. Université de Strasbourg, 2017. Français. ⟨NNT : 2017STRAJ103⟩. ⟨tel-01813438⟩

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