Skip to Main content Skip to Navigation

Survenue de grossesses chez les femmes atteintes de mucoviscidose : spécificités démographiques et sanitaires

Abstract : Cystic fibrosis is a progressive genetic disease with multiple levels of harm that affects nearly 7000 people in France. Over the last decades, health care improvements has led to an increase in patients’ life expectancy and hence the proportion of adults in the affected population. This has naturally led to new issues relative to the life of patients, notably procreation. Data from the French Cystic Fibrosis Register recorded between 1992 and 2011 were used in this work, firstly to study the fertility of that population and to pinpoint the characteristics of female patients, secondly to identify any interaction between cystic fibrosis and the occurrence of pregnancy. Results showed a discrepancy between the fertility of general French population and that of the patients, which is partly explained when considering the young age of the patients and their conjugal and school behaviour. By studying their characteristics, an increase in both the age and the number of women being followed, as well as an improvement in their health and the treatments provided to them are observed. In the following multivariate analyses single out the most predictive characteristics of the occurrence of first pregnancy: while some medical variables appear to be significant, most of those are socio-demographic. Finally, those analyses showed that the short-term effect of pregnancy on the patients’ state of health does not appear to be evident and remains low when it occurs ; however specific modalities or events throughout the course of the pregnancy could have an impact on the mother’s health.
Document type :
Complete list of metadatas
Contributor : Abes Star :  Contact
Submitted on : Thursday, June 7, 2018 - 3:29:08 PM
Last modification on : Friday, October 23, 2020 - 5:03:22 PM
Long-term archiving on: : Saturday, September 8, 2018 - 2:30:57 PM


Version validated by the jury (STAR)


  • HAL Id : tel-01810184, version 1



Pauline Castaing. Survenue de grossesses chez les femmes atteintes de mucoviscidose : spécificités démographiques et sanitaires. Démographie. Université de Bordeaux, 2017. Français. ⟨NNT : 2017BORD0740⟩. ⟨tel-01810184⟩



Record views


Files downloads