Skip to Main content Skip to Navigation
Theses

Implications des N-acyl homosérine lactones, molécules du quorum sensing dans les maladies inflammatoires chroniques intestinales

Abstract : Quorum sensing molecules N-acyl-homoserine lactones (AHLs) involved in bacterial communication network are also able to interact with eukaryotic cells. Searching for these molecules in the context of inflammatory bowel diseases (IBD) and more precisely when studying consequences of dysbiosis on gut inflammation pathways is appealing. Using mass spectrometry, we identified for the first time AHLs in human intestinal ecosystem, and among them a new AHL, 3-oxo-C12:2 which is prominent. This AHL correlates with normobiosis, is lost IBD and exerts protective effect on gut epithelial cells. In fact, 3-oxo-C12:2 exerts anti-inflammatory effect in vitro on Caco-2 cells without increased paracellular permeability. Furthermore, first results from in vivo experiments show that 3-oxo-C12:2 is also able to influence mice gut microbiota composition. These results open multiple perspectives especially on new ecological treatments in IBD.
Document type :
Theses
Complete list of metadatas

https://tel.archives-ouvertes.fr/tel-01807764
Contributor : Abes Star :  Contact
Submitted on : Tuesday, June 5, 2018 - 10:30:26 AM
Last modification on : Tuesday, October 20, 2020 - 11:32:21 AM
Long-term archiving on: : Thursday, September 6, 2018 - 1:40:47 PM

File

2017PA066489.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-01807764, version 1

Citation

Cécilia Landman. Implications des N-acyl homosérine lactones, molécules du quorum sensing dans les maladies inflammatoires chroniques intestinales. Microbiologie et Parasitologie. Université Pierre et Marie Curie - Paris VI, 2017. Français. ⟨NNT : 2017PA066489⟩. ⟨tel-01807764⟩

Share

Metrics

Record views

372

Files downloads

841