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Reconstruction conjointe de l’ordre des gènes de génomes actuels et ancestraux et de leur évolution structurale dans un cadre phylogénétique

Abstract : The early 2000s saw the emergence of high-throughput sequencing technologies that would bring down the time and cost of sequencing the entire genome and opening the perspective to whole genome-scale species phylogeny. In this perspective, methods for the inference of evolutionary history of the order of genomic markers along a phylogeny have been developed. However, assemblies of a majority of the large eukaryotic genomes remain incompletely resolved and therefore do not, as such, allow their exploitation for the reconstruction of evolutionary history of the order of the genes of these species. It is in this context that we have developed the algorithm ADseq which allows to jointly reconstruct the evolutionary history of the order of genes by considering the fragmentation of the extant genomes and improve the assembly of these by comparative genomics
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Yoann Anselmetti. Reconstruction conjointe de l’ordre des gènes de génomes actuels et ancestraux et de leur évolution structurale dans un cadre phylogénétique. Bio-informatique [q-bio.QM]. Université de Lyon, 2017. Français. ⟨NNT : 2017LYSE1242⟩. ⟨tel-01807638⟩

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