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Réactions domino et semi-hydrogénation anti des alcynes ; Imidates et amidines : synthèse et activité biologique

Abstract : During this research, the firstmethylenation-hydrogenation domino process of aldehydes and ketones has been studied. This process is based on the combination of a gem-bimetallic reagent [CH2(ZnI)2] and a Wilkinson catalyst (ClRh(PPh3)3). The scope and limitations of this reaction have been explored.Furthermore, the semi-hydrogenation antiof internal alkynes by homogeneous catalysis allowed stereoselective access to the corresponding alkenes (E). This reaction was developed using commercially available and low expensive reagents: Zn0, ZnI2 and Cl2Pd(PPh3)2under H2 atmosphere. The use of easy handle and soft conditions had been first described.Finally, two synthetic routes were used to prepare imidates and amidines. The first were obtained from furfurylamine and iminoesters, while amidines were prepared from the condensation of primary amines on previous imidates. Evaluation of the antioxidant activity of these compounds gave promising results.
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Radhouan Maazaoui. Réactions domino et semi-hydrogénation anti des alcynes ; Imidates et amidines : synthèse et activité biologique. Chimie organique. Université Pierre et Marie Curie - Paris VI; Faculté des sciences de Bizerte (Tunisie), 2017. Français. ⟨NNT : 2017PA066334⟩. ⟨tel-01799642⟩

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