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Physiologie isotopique du Calcium chez les mammifères

Abstract : Environment influences the isotope compositions of body Ca and vertebrate physiology affects these compositions in turn. These observations have allowed recognition of possible applications for Ca isotopes, in the field of medical biology, with the assessment of bone mineral balance in human, and in (palaeo-)ecology for the study of past and present day diets in vertebrates. These applications depend on a better fundamental understanding of causes for these variations. This thesis aims at identifying the main mechanisms responsible for variability of Ca isotope compositions in mammals and human. A solution mode analysis protocol was first developed for MC-ICP-MS. Two methods for microsampling of tooth enamel were then compared in order to increase spatial resolution of mineralized tissues analysis. The influence of dietary Ca sources has been discussed. Isotope composition of human diet is variable because of the diversity of Ca primary sources but also due to variations in dairy products proportions in diet. Early dietary transitions, such as weaning, can be studied using the Ca isotope compositions of human deciduous tooth enamel.Based on observations in human and other mammals, the mechanisms responsible for Ca isotope fractionations are discussed. A mathematical model was developed, allowing the identification of some mechanisms responsible for Ca isotope distribution across organism reservoirs, and sheds light on the crucial role of kidney in determination of bone isotope compositions.
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Submitted on : Friday, May 25, 2018 - 1:01:09 AM
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  • HAL Id : tel-01799638, version 1


Théo Tacail. Physiologie isotopique du Calcium chez les mammifères. Sciences de la Terre. Université de Lyon, 2017. Français. ⟨NNT : 2017LYSEN071⟩. ⟨tel-01799638⟩



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