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Etude des mécanismes d’action de l’ocytocine sur la modulation des circuits astro-neuronaux de régulation de la douleur

Abstract : Pain is a complex phenomenon arising from the nervous system. Numerous molecules modulate pain through complex and various mechanisms. One of those, oxytocin, is more famous for its roles in reproduction and social interactions, but is also a potent endogenous analgesic. During this thesis, I tried to understand how oxytocin modulates pain in two brain regions, the hypothalamus and the amygdala. This work unveiled a small group of oxytocinergic neurons in the hypothalamus which control pain through a dual action, firstly by inhibiting the pain signals in the spinal cord and secondly by activating at the same time another population of oxytocinergic neurons, which then secrete oxytocin in the bloodstream. In the amygdala, we showed that the analgesic effect of oxytocin required the proper functioning of a non-neuronal cell type, the astrocyte, which responds to oxytocin and, doing so, allows the activation of neural circuits which modulate pain.
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Submitted on : Saturday, May 19, 2018 - 1:03:37 AM
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  • HAL Id : tel-01796058, version 1

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Jérôme Wahis. Etude des mécanismes d’action de l’ocytocine sur la modulation des circuits astro-neuronaux de régulation de la douleur. Neurobiologie. Université de Strasbourg, 2017. Français. ⟨NNT : 2017STRAJ015⟩. ⟨tel-01796058⟩

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