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Mise en évidence d'un dialogue entre la signalisation œstrogénique et le syndécane-1 dans les cellules de carcinome mammaire humain MCF7

Abstract : Breast cancer is the most common cancer in women. Its growth and progression depend on hormone signals, such as estrogens, and on interactions with the matrix microenvironment. The loss of the estrogen receptor ERα expression is a poor prognosis marker and predicts a resistance to antihormonal therapies. In these aggressive tumors, SDC-1 expression, a transmembrane proteoglycan involved in angiogenesis, proliferation and invasiveness is increased suggesting an antagonism between estrogenic signaling and SDC-1 in breast tumors. Using ER (+) MCF7 mammary carcinoma cells, we have shown that estrogens via the ERα are able to inhibit the expression of SDC-1 by a mechanism requiring protein synthesis and phosphorylation of ERα by the IKK kinase. Additionally, our results show that dysregulation of SDC-1 expression affects the proliferative response to estrogens in MCF7 cells by altering the subcellular localization of ERα. Our results show both a tonic and E2-induced inhibition of SDC-1 expression by ERα in MCF7 cells and the potentiality of SDC-1 to reduce the estrogenic response of these cells. Thus, these results support the hypothesis that an antagonism between ERα signaling and SDC-1 which could influence the phenotypic orientation of mammary carcinoma cells.
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https://tel.archives-ouvertes.fr/tel-01794495
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  • HAL Id : tel-01794495, version 1

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Emmanuelle Fleurot. Mise en évidence d'un dialogue entre la signalisation œstrogénique et le syndécane-1 dans les cellules de carcinome mammaire humain MCF7. Médecine humaine et pathologie. Normandie Université, 2017. Français. ⟨NNT : 2017NORMC423⟩. ⟨tel-01794495⟩

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