Skip to Main content Skip to Navigation
Theses

Études fonctionnelle et structurale de deux protéines rétrovirales d’intérêt thérapeutique : la protéine Tax du virus HTLV et la protéine de capside du FIV

Abstract : Retroviruses are a major concern of public health in humans but also in animals. A better understanding of the structural determinants underlying the functions of retroviral proteins is a crucial step for the development of efficient antiretroviral therapies.This manuscript studies the structural basis of the molecular mechanisms implicated in key functions of retroviruses such as, i) the regulation of complex retroviruses protein expression and ii) the assembly of viral particles, through the study of two retroviral proteins of therapeutic interest: the human T-lymphotropic virus (HTLV) Tax protein and the feline immunodeficiency virus (FIV) capsid protein. The functional and structural studies of these two proteins and the understanding of the molecular mechanisms required for their functions will pave the way to the conception of new antiretroviral therapeutic strategies.Despite several expression and purification assays, no structural studies could be performed for the HLTV Tax protein. However, this study allowed the resolution of the first structure for the full-length FIV capsid protein by X-ray crystallography. Although the FIV capsid protein displays a standard a-helical topology like other retroviral CAs, it also harbors original features whose functional consequences will be discussed
Document type :
Theses
Complete list of metadatas

Cited literature [47 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-01791976
Contributor : Abes Star :  Contact
Submitted on : Tuesday, May 15, 2018 - 10:09:09 AM
Last modification on : Wednesday, November 20, 2019 - 3:24:21 AM
Long-term archiving on: : Monday, September 24, 2018 - 11:09:05 AM

File

TH2017FolioChristelle.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-01791976, version 1

Collections

Citation

Christelle Folio. Études fonctionnelle et structurale de deux protéines rétrovirales d’intérêt thérapeutique : la protéine Tax du virus HTLV et la protéine de capside du FIV. Biochimie, Biologie Moléculaire. Université de Lyon, 2017. Français. ⟨NNT : 2017LYSE1245⟩. ⟨tel-01791976⟩

Share

Metrics

Record views

270

Files downloads

137