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Evaluation et impact de la dysfonction diaphragmatique au cours du sevrage de la ventilation mécanique chez le patient adulte de réanimation

Abstract : Diaphragm dysfunction and critical illness associated neuropathy and myopathy are frequently suspected to cause weaning failure from mechanical ventilation. Some data suggest that both may be gathered into a same entity with two localisations, respiratory and peripheral. This thesis highlights that diaphragm dysfunction and critical illness neuromyopathy are two distinct diseases that don’t frequently coexist. In addition, diaphragm dysfunction has a more severe impact on weaning outcome and prognosis than critical illness associated neuromyopathy and myopathy. However, the level of diaphragm function required to ensure safe mechanical ventilation discontinuation is lower than the level of diaphragm function defining diaphragm dysfunction. This work also shows that investigating diaphragm function may be simplified by the use of ultrasound and diaphragm electromyogram activity.
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  • HAL Id : tel-01788333, version 1

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Martin Dres. Evaluation et impact de la dysfonction diaphragmatique au cours du sevrage de la ventilation mécanique chez le patient adulte de réanimation. Physiologie [q-bio.TO]. Université Pierre et Marie Curie - Paris VI, 2017. Français. ⟨NNT : 2017PA066253⟩. ⟨tel-01788333⟩

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