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Expositions agrégées aux composés organiques semi-volatils dans l'habitat et risques sanitaires associés

Abstract : In housing, people are exposed to an increasing number of chemicals, including semivolatile organic compounds (SVOCs). SVOCs are present on surfaces, in the gas phase, airborne particles and settled dust. Humans are exposed through ingestion, inhalation and dermal contact. Many of these compounds have suspected toxic effects on human health. The objective of this thesis is to assess, by a risk assessment approach, the public health risk posed by the exposure to SVOCs frequently detected in French dwellings. At first, indoor exposures were estimated for 32 compounds from contamination data and human parameters such as body weight, inhalation rate, time spent in dwellings etc. Ingestion, inhalation and dermal contact exposure pathways were aggregated for the indoor SVOCs of greatest concern and for several age groups from birth to age 30. In a second step, human health risks were modeled from these exposures and from available toxicity data. Each SVOC was considered separately and also in mixtures, based on the assumption of dose additivity. This work provided exposures distributions representative of the French population and identified the dominant media and exposure routes for each compound as well as the most at risk SVOCs for a certain portion of the French population.
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Submitted on : Monday, May 7, 2018 - 11:33:06 AM
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  • HAL Id : tel-01787085, version 1


Maud Pelletier. Expositions agrégées aux composés organiques semi-volatils dans l'habitat et risques sanitaires associés. Santé publique et épidémiologie. Université Rennes 1, 2017. Français. ⟨NNT : 2017REN1B028⟩. ⟨tel-01787085⟩



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