L. Chen, T. Evans, S. Anand, J. Boufford, H. Brown et al., Human resources for health: overcoming the crisis, The Lancet, vol.364, issue.9449, pp.1984-90, 2004.
DOI : 10.1016/S0140-6736(04)17482-5

W. Van-damme, K. Kober, G. Kegels, C. Gilks, C. Dye et al., Scaling-up antiretroviral treatment in Southern African countries with human resource shortage: how will health systems adapt? Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. The Lancet, Soc Sci Med, vol.66373, issue.109657, pp.2108-2148, 2008.

M. Cohen, HIV treatment as prevention and "the Swiss statement": in for a dime, in for a dollar? Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2010.

. Maxart and A. Maximizing, Available from: http://www.stopaidsnow.org/maxartimplementation-study-treatment-prevention [Access date, p.2017, 2015.

C. Iwuji, J. Orne-gliemann, F. Tanser, S. Boyer, R. Lessells et al., Evaluation of the impact of immediate versus WHO recommendations-guided antiretroviral therapy initiation on HIV incidence: the ANRS 12249 TasP (Treatment as Prevention) trial in Hlabisa sub-district, KwaZulu-Natal, South Africa: study protocol for a cluster randomised controlled trial, Trials, vol.14, issue.1, p.230, 2013.
DOI : 10.1073/pnas.1209017110

E. Gardner, M. Mclees, J. Steiner, D. Rio, C. Burman et al., The spectrum of engagement in HIV care and its relevance to test-and-treat strategies for prevention of HIV infection Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, pp.793-800, 2011.

J. Bor, A. Herbst, M. Newell, T. M. Barnighausen, G. Chêne et al., Increases in Adult Life Expectancy in Rural South Africa: Valuing the Scale-Up of HIV Treatment Prognosis of HIV-1- infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies. The Lancet, Science. Egger M, vol.339360, issue.109327, pp.961-5119, 2002.

S. Attia, M. Egger, M. Muller, M. Zwahlen, and N. Low, Sexual transmission of HIV according to viral load and antiretroviral therapy: systematic review and meta-analysis, AIDS, vol.23, issue.11, 2009.
DOI : 10.1097/QAD.0b013e32832b7dca

S. Rosen, B. Larson, A. Brennan, L. Long, M. Fox et al., Economic Outcomes of Patients Receiving Antiretroviral Therapy for HIV/AIDS in South Africa Are Sustained through Three Years on Treatment The Epidemiologic and Economic Impact of Improving HIV Testing, Linkage, and Retention in Care in the United States Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Universal test and treat and the HIV epidemic in rural South Africa: a phase 4, open-label, community cluster randomised trial. The Lancet HIV. 2017. 15 Risk factors, barriers and facilitators for linkage to antiretroviral therapy care: a systematic review, PloS one. AIDS, vol.56226, issue.9216, pp.12731-13220, 2010.

L. Tso, J. Best, R. Beanland, M. Doherty, M. Lackey et al., Facilitators and barriers in HIV linkage to care interventions, AIDS, vol.30, issue.10, pp.1639-53, 2016.
DOI : 10.1097/QAD.0000000000001101

L. Bogart, S. Chetty, J. Giddy, A. Sypek, L. Sticklor et al., Barriers to care among people living with HIV in South Africa: Contrasts between patient and healthcare provider perspectives, AIDS Care, vol.25, issue.7, pp.843-53, 2013.
DOI : 10.1089/apc.2007.0198

J. Tucker, L. Tso, B. Hall, Q. Ma, R. Beanland et al., Enhancing Public Health HIV Interventions: A Qualitative Meta-Synthesis and Systematic Review of Studies to Improve Linkage to Care, Adherence, and Retention. EBioMedicine Defeating AIDS?advancing global health. The Lancet World Health Organization. Guideline on when to start antiretroviral therapy and on preexposure prophylaxis for HIV A life course approach to chronic disease epidemiology: conceptual models, empirical challenges and interdisciplinary perspectives, Int J Epidemiol, vol.38631, issue.212, pp.171-218285, 2002.

S. Henly, J. Wyman, M. Findorff, G. Defossez, A. Rollet et al., Health and Illness Over Time, Nursing Research, vol.60, issue.Supplement, pp.5-1424, 2011.
DOI : 10.1097/NNR.0b013e318216dfd3
URL : http://pdfs.journals.lww.com/nursingresearchonline/2011/05001/Health_and_Illness_Over_Time__The_Trajectory.2.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1506371092263;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzd8JWXnemdCNw7G3bMWeepzr6+QcnBxS+zQ6AVopoitj5qBZakTrk57+2O9uviBDEF;hash|nZPnD9L568liemGHHjFCcg==

S. Darak, M. Mills, V. Kulkarni, S. Kulkarni, I. Hutter et al., Trajectories of Childbearing among HIV Infected Indian Women: A Sequence Analysis Approach Uptake of Home-Based HIV Testing, Linkage to Care, and Community Attitudes about ART in Rural KwaZulu- Natal, South Africa: Descriptive Results from the First Phase of the ANRS 12249 TasP Cluster- Randomised Trial. PLoS medicine, PloS one, vol.1013, issue.48, pp.1002107-1002134, 2015.

J. Zaidi, E. Grapsa, F. Tanser, M. Newell, and T. Barnighausen, Dramatic increase in HIV prevalence after scale-up of antiretroviral treatment, AIDS, vol.27, issue.14, pp.2301-2306, 2013.
DOI : 10.1097/QAD.0b013e328362e832

C. Houlihan, R. Bland, P. Mutevedzi, R. Lessells, J. Ndirangu et al., Addressing social issues in a universal HIV test and treat intervention trial (ANRS 12249 TasP) in South Africa: methods for appraisal Cohort profile: Hlabisa HIV treatment and care programme, BMC public health. Int J Epidemiol, vol.1540, issue.292, pp.209318-209344, 2011.

K. Murray, L. Dulli, K. Ridgeway, D. Santo, L. Darrow-de-mora et al., Improving retention in HIV care among adolescents and adults in low-and middle-income countries: A systematic review of the literature Retention in HIV care for individuals not yet eligible for antiretroviral therapy: rural KwaZulu-Natal Journal of acquired immune deficiency syndromes, ):e0184879. 31. Lessells RJ, pp.79-86, 2011.

V. Audigier, F. Husson, J. Josse, F. Husson, S. Lê et al., Statistical Theory and Method. 2013. 33 Exploratory multivariate analysis by example using R From HIV infection to therapeutic response: a population-based longitudinal HIV cascade-of-care study in KwaZulu-Natal, South Africa. The Lancet HIV. 2017. 35 Access to HIV care in the context of universal test and treat: challenges within the ANRS 12249 TasP clusterrandomized trial in rural South Africa, ):20913. 36. Department of Health -Republic of South Africa. National South African Strategic Plan on HIV-STIs and TB Available from, pp.2012-2016, 2010.

J. Bor, S. Ahmed, M. Fox, S. Rosen, G. Meyer-rath et al., Effect of eliminating CD4- count thresholds on HIV treatment initiation in South Africa: An empirical modeling study. PloS one Improving ART programme retention and viral suppression are key to maximising impact of treatment as prevention -a modelling study, BMC infectious diseases, vol.1217, issue.61, pp.178249-38557, 2017.

D. Govindasamy, J. Meghij, E. Negussi, R. Baggaley, and N. Ford, Interventions to improve or facilitate linkage to or retention in pre-ART (HIV) care and initiation of ART in low- and middle-income settings - a systematic review, Journal of the International AIDS Society, vol.16, issue.198, 2014.
DOI : 10.7448/IAS.16.1.18579

J. Andrews, R. Wood, L. Bekker, K. Middelkoop, R. Walensky et al., Projecting the benefits of antiretroviral therapy for HIV prevention: the impact of population mobility and linkage to care. The Journal of infectious diseases Home testing and counselling with linkage to care. The lancet HIV, pp.543-51, 2012.

J. Parkhurst, Y. Voss-de-lima, D. Evans, L. Page-shipp, A. Barnard et al., Bull World Health Organ Linkage to care and treatment for TB and HIV among people newly diagnosed with TB or HIV-associated TB at a large, inner city South African hospital Depressive symptoms and their impact on health-seeking behaviors in newly-diagnosed HIV-infected patients in Durban, PloS one. AIDS and behavior, vol.88816, issue.448, pp.519-262226, 2010.

Q. Ma, L. Tso, Z. Rich, B. Hall, R. Beanland et al., Barriers and facilitators of interventions for improving antiretroviral therapy adherence: a systematic review of global qualitative evidence Barriers and Facilitators to Interventions Improving Retention in HIV Care: A Qualitative Evidence Meta-Synthesis. AIDS and behavior, PLoS medicine, pp.21166-461755, 2016.

J. Bertolli, R. Shouse, L. Beer, E. Valverde, J. Fagan et al., Using HIV surveillance data to monitor missed opportunities for linkage and engagement in HIV medical care. The open AIDS journal, pp.131-172, 2012.

J. Bertolli, P. Garland, E. Valverde, L. Beer, J. Fagan et al., Missed Connections: HIV-Infected People Never in Care. Public Health Reports, pp.117-143, 2013.

S. Boyer, C. Iwuji, A. Gosset, C. Protopopescu, N. Okesola et al., Factors associated with antiretroviral treatment initiation amongst HIV-positive individuals linked to care within a universal test and treat programme: early findings of the ANRS 12249 TasP trial in rural South Africa, AIDS Care, vol.50, issue.6, pp.39-51, 2016.
DOI : 10.1097/QAD.0b013e328362e832

M. Studer, G. Ritschard, A. Gabadinho, and N. Müller, Discrepancy Analysis of State Sequences. Sociological Methods and Research, pp.471-510, 2011.

. Unaids, Global AIDS update 2016 Available from: http://www.unaids.org/sites/default/files/media_asset/global-AIDS-update-2016_en.pdf [Access date, p.2017

T. Barnighausen, N. Eyal, and D. Wikler, HIV treatment-as-prevention research at a crossroads PLoS medicine):e1001654. 3. Insight START study group, 2014.

C. Danel, R. Moh, D. Gabillard, A. Badje, L. Carrou et al., A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa, pp.795-807808, 2015.

T. Quinn, M. Wawer, N. Sewankambo, D. Serwadda, C. Li et al., Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group, pp.921-930, 2000.

F. Tanser, T. Barnighausen, E. Grapsa, J. Zaidi, and M. Newell, High Coverage of ART Associated with Decline in Risk of HIV Acquisition in Rural KwaZulu-Natal, South Africa, Science, vol.22, issue.19, pp.966-71, 2013.
DOI : 10.1002/sim.1541

J. Available-from-eaton, L. Johnson, J. Salomon, T. Barnighausen, E. Bendavid et al., HIV treatment as prevention: systematic comparison of mathematical models of the potential impact of antiretroviral therapy on HIV incidence in South Africa Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model, PLoS medicine. Granich RM The Lancet, vol.109373, issue.201279657, pp.1001245-1148, 2009.

J. Hontelez, M. Lurie, T. Barnighausen, R. Bakker, R. Baltussen et al., Elimination of HIV in South Africa through expanded access to antiretroviral therapy: a model comparison study PLoS medicine Modeling Scenarios for the End of AIDS. Clinical Infectious Diseases HIV treatment as prevention: considerations in the design, conduct, and analysis of cluster randomized controlled trials of combination HIV prevention Impact of early initiation versus national standard of care of antiretroviral therapy in Swaziland's public sector health system: study protocol for a stepped-wedge randomized trial. Trials, ):e1001250. 15. BCPP. Botswana Combination Prevention Project. 2015 Available from, pp.1001534-1001547, 2012.

N. Peer, R. English, A. Padarath, P. Barron, C. Day et al., KwaZulu- Natal, South Africa: study protocol for a cluster randomised controlled trial Available from: http://www.statssa.gov.za/census Effect of concurrent sexual partnerships on rate of new HIV infections in a high-prevalence, rural South African population: a cohort study The Lancet, incidence: the ANRS 12249 TasP (Treatment as Prevention) trial in Hlabisa sub-district, pp.230247-55, 2011.

J. Zaidi, E. Grapsa, F. Tanser, M. Newell, T. Barnighausen et al., Dramatic increase in HIV prevalence after scale-up of antiretroviral treatment Cohort profile: Hlabisa HIV treatment and care programme Department of Health -Republic of South Africa. National South African guidelines for ART - 2013. 2013 Available from: http://www.sahivsoc.org/Files, AIDS Int J Epidemiol, vol.2740, issue.25, pp.2301-5318, 2011.

. Available, R. Hayes, K. Sabapathy, S. Fidler, and T. Evans, pdf [Access date: 26/09 Universal testing and treatment as an HIV prevention strategy: research questions and methods. Current HIV research The global shortage of health workers: an opportunity to transform care. The Lancet, pp.429-452576, 2011.

J. Campbell, K. Admasu, A. Soucat, and S. Tlou, Maximizing the impact of community-based practitioners in the quest for universal health coverage. Bull World Health Organ, p.590, 2015.

T. Hallett, J. Eaton, H. Bygrave, M. Doherty, P. Ehrenkranz et al., 31. UNAIDS. HIV care and support taking into account the 2016 WHO consolidated guidelines. 2016 Available from Reimagining HIV service delivery: the role of differentiated care from prevention to suppression1:3. 33 Implementation of provider-based electronic medical records and improvement of the quality of data in a large HIV program in Sub-Saharan Africa Available from: http://www.unaids.org/sites/default/files/media_asset/AIDS-by-the-numbers-2016_en.pdf. 35. World Health Organization. Guideline on when to start antiretroviral therapy and on pre- exposure prophylaxis for HIV, ):e51631. 34. UNAIDS. AIDS by the numbers 2016lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS), pp.228-260, 2012.

R. Gallo, S. Salahuddin, M. Popovic, G. Shearer, M. Kaplan et al., HTLV-III) from patients with AIDS and at risk for AIDS. Science Centers for Disease Control and Prevention Kaposi's sarcoma and Pneumocystis pneumonia among homosexual men--New York City and California. MMWR Morbidity and mortality weekly report 40. UNAIDS. World factsheet -HIV and AIDS estimates. 2017 Available from: http://www.unaids.org/sites/default/files/media_asset/UNAIDS_FactSheet_en Origins of HIV and the AIDS pandemic. Cold Spring Harbor perspectives in medicine Department of Health -Republic of South Africa. National South African Strategic Plan on HIV-STIs and TB, 2012-2016. 2016 Available from: http://sanac.org Localized spatial clustering of HIV infections in a widely disseminated rural South African epidemic, al. South African National HIV Prevalence, Incidence and Behaviour Survey Available from, pp.500-503, 1981.

H. Coovadia and S. Karim, UNAIDS Local epidemics issues brief Available from: http://www.unaids.org/sites/default/files/media_asset/JC2559_local-epidemics_en.pdf [Access date: 2017/09/19]. 47. Department of Health -Republic of South Africa. The 2011 National Antenatal Sentinel HIV & Syphilis Prevalence Survey in South Africa Available from: https://www.health-e.org.za/wp- content Socio-medical indicators of health in South Africa. International journal of health services : planning, administration, evaluation HIV infection and tuberculosis in South, pp.1008-16163, 1986.

A. Karim, Q. Kharsany, A. Frohlich, J. Werner, L. Mlotshwa et al., Human Sciences Research Council South African National HIV Prevalence, Incidence and Behaviour Survey, 2012. 2012 Available from: www.hsrc.ac Transmission networks and risk of HIV infection in KwaZulu-Natal, South Africa: a community-wide phylogenetic study. The Lancet HIV Department of Health -Republic of South Africa. South Africa's national strategic plan for HIV, TB and STIs 2017-2022. 2017 Available from: http://sanac.org.za/wp- content/uploads Factors Driving the HIV Epidemic in Southern Africa Available from: https://www.health-e.org.za/wp-content/uploads Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. The New England journal of medicine A brief history of antiretroviral therapy of HIV infection: success and challenges. Annali dell'Istituto superiore di sanita Cihlar T, Fordyce M. Current status and prospects of HIV treatment. Current opinion in virology World Health Organization Antiretroviral therapy for HIV infection in adults and adolescents: recommendations for a public health approach. 2006 (revision) Antiretroviral therapy for HIV infection in adults and adolescents -Recommendations for a public health approach -2010 revision, HIV Incidence in Young Girls in KwaZulu-Natal, South Africa-Public Health Imperative for Their Inclusion in HIV Biomedical Intervention Trials Available from Available from, pp.1870-1876, 1998.

V. Jain and S. Deeks, When to Start Antiretroviral Therapy, Current HIV/AIDS Reports, vol.300, issue.2, 2010.
DOI : 10.1097/00042560-199808010-00004

J. Lundgren, A. Babiker, F. Gordin, Á. Borges, and J. Neaton, When to start antiretroviral therapy: the need for an evidence base during early HIV infection. BMC medicine):148. 63. World Health Organization. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. 2013 Available from: http://apps.who.int/iris/bitstream, p.2017, 2013.

R. Moore, K. Gebo, G. Lucas, J. Keruly, J. Kowalska et al., Rate of comorbidities not related to HIV infection or AIDS among HIV-infected patients, by CD4 cell count and HAART use status Clinical infectious diseases : an official publication of the Infectious Diseases Society of America A standardized algorithm for determining the underlying cause of death in HIV infection as AIDS or non- AIDS related: results from the EuroSIDA study. HIV clinical trials, al. CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection, pp.1102-4109, 2008.

E. Tagar, M. Sundaram, K. Condliffe, B. Matatiyo, F. Chimbwandira et al., Facility-Level ART Unit Cost Analysis in Ethiopia, Malawi, Rwanda, South Africa and Zambia World Health Organization Progress report 2016 -Prevent HIV, Test and Treat all -WHO support for Country impact Available from: http://apps.who.int/iris/bitstreamWHO-HIV-2016.24-eng.pdf?ua=1 [Access date: 2017/06/03]. 69. UNAIDS. UNAIDS Prevention Gap Report. 2016 Available from: http://www.unaids.org/sites/default/files/media_asset/2016-prevention-gap-report_en.pdf [Access date Department of Health -Republic of South Africa. National South African Strategic Plan on HIV-STIs and TB Available from: http://data.unaids.org/pub/externaldocument, Multi- Country Analysis of Treatment Costs for HIV South Africa National AIDS Council Trust. UNAIDS 2015 Global AIDS Response Progress Report (GARPR) of South Africa. 2015 Available from, 2007.

C. Iwuji, N. Mcgrath, D. Oliveira, T. Porter, K. Pillay et al., The Art of HIV Elimination: Past and Present Science, J AIDS Clin Res, vol.6, issue.525, 2015.

S. Mccormack, M. Gafos, M. Desai, M. Cohen, A. Kurth et al., Biomedical Prevention: State of the Science Combination HIV prevention: significance, challenges, and opportunities Advancing combination HIV prevention advocacy, Clinical Infectious Diseases Current HIVAIDS reports International HIV/AIDS Available, vol.598, issue.77, pp.41-662, 2011.

J. Parkhurst, P. Pronyk, J. Hargreaves, J. Kim, L. Morison et al., Structural approaches for prevention of sexually transmitted HIV in general populations: definitions and an operational approach Effect of a structural intervention for the prevention of intimate-partner violence and HIV in rural South Africa: a cluster randomised trial Behavioural strategies to reduce HIV transmission: how to make them work better. The Lancet, Journal of the International AIDS Society. Lancet, vol.17368372, issue.809639, pp.1973-83669, 2006.

D. Ross, Behavioural interventions to reduce HIV risk: what works?, AIDS, vol.24, issue.Suppl 4
DOI : 10.1097/01.aids.0000390703.35642.89
URL : http://pdfs.journals.lww.com/aidsonline/2010/10004/Behavioural_interventions_to_reduce_HIV_risk__what.2.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1504449093475;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzdN2ziiHhY6wPF9tfA80junms+dBBR+CaCDa9oefgunww=;hash|WlQmRYk4X+B47Pk11pZkZQ==

M. Kulich, D. Celentano, C. Zelaya, S. Chariyalertsak, and A. Chingono, Effect of community-based voluntary counselling and testing on HIV incidence and social and behavioural outcomes (NIMH Project Accept; HPTN 043): a cluster-randomised trial. The Lancet Global Health, pp.267-77, 2010.

S. Weller, K. Davis-beaty, S. Weller, M. Beksinska, J. Smit et al., Condom effectiveness in reducing heterosexual HIV transmission Progress and challenges to male and female condom use in South Africa. Sexual health, pp.51-59, 2002.

B. Auvert, D. Taljaard, E. Lagarde, J. Sobngwi-tambekou, R. Sitta et al., Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial. PLoS medicine Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial. The Lancet Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial. The Lancet, pp.298-86657, 2005.
URL : https://hal.archives-ouvertes.fr/inserm-00700701

N. Siegfried, M. Muller, J. Deeks, and J. Volmink, Male circumcision for prevention of heterosexual acquisition of HIV in men. The Cochrane database of systematic reviews, CD003362. 89. World Health Organization, UNAIDS. Joint Strategic Action Framework to Accelerate the, 2009.

H. Weiss and J. Viljoen, Available from: http://files.unaids.org/en/media The acceptability of male circumcision as an HIV intervention among a rural Zulu population, AIDS care, vol.17, issue.3, pp.304-317, 2005.

J. Hoffman, K. Arendse, C. Larbi, N. Johnson, and L. Vivian, Perceptions and knowledge of voluntary medical male circumcision for HIV prevention in traditionally non-circumcising communities in South Africa, Global Public Health, vol.5, issue.5-6, pp.5-6692, 2015.
DOI : 10.1007/s10461-006-9169-4

J. Sexton, G. Garnett, and J. Rottingen, Metaanalysis and metaregression in interpreting study variability in the impact of sexually transmitted diseases on susceptibility to HIV infection. Sexually transmitted diseases, pp.351-358, 2005.

J. Glynn, S. Biraro, H. Weiss, R. Hayes, D. Watson-jones et al., Herpes simplex virus type 2: a key role in HIV incidence Treatment of sexually transmitted infections for HIV prevention: end of the road or new beginning?, AIDS AIDS, vol.2324, issue.12, pp.1595-1603, 2009.

D. Fleming and J. Wasserheit, From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection South African National AIDS Council (SANAC) Progress report on the national strategic plan for HIV, TB and STIs (2012-2016) 2014 Available from: http://sanac.org.za/wp- content/uploads, South African National Blood Service (SANBS). Integral annula report of the South African National Blood Service. 2016 Available from, pp.3-17, 1999.

S. Reid, Injection drug use, unsafe medical injections, and HIV in Africa: a systematic review, Harm Reduction Journal, vol.6, issue.1
DOI : 10.1186/1477-7517-6-24

O. Shisana, C. Connolly, T. Rehle, S. Mehtar, and P. Dana, HIV risk exposure among South African children in public health facilities. AIDS care, Harm Reduct J, vol.620, issue.7, pp.24-99755, 2008.
DOI : 10.1080/09540120701771705

P. Health, S. Council, and . Africa, Guidelines for good practices in the healthcare professions Available from: http://www.hpcsa.co.za, p.2017, 2008.

E. Aspinall, D. Nambiar, D. Goldberg, M. Hickman, A. Weir et al., Are needle and syringe programmes associated with a reduction in HIV transmission among people who inject drugs: a systematic review and meta-analysis, International Journal of Epidemiology, vol.56, issue.1, pp.235-283, 2014.
DOI : 10.1136/jech.56.2.119

Z. Petersen, B. Myers, M. Van-hout, A. Plüddemann, and C. Parry, Availability of HIV prevention and treatment services for people who inject drugs: findings from 21 countries, Harm Reduction Journal, vol.10, issue.1, p.13, 2013.
DOI : 10.1111/j.1465-3362.2009.00154.x

A. Scheibe, D. Makapela, B. Brown, M. Santos, F. Hariga et al., HIV prevalence and risk among people who inject drugs in five South African cities. The International journal on drug policy, pp.107-122, 2016.

L. Weich, H. Nowbath, S. Flegar, Z. Mahomedy, H. Ramjee et al., South African guidelines for the management of opioid dependence. Updated 2013. 2013 Available from: https://www.saams.co.za/Content, p.2017

B. Walker, R. Ahmed, and S. Plotkin, Moving ahead an HIV vaccine: Use both arms to beat HIV, Nature Medicine, vol.58, issue.10
DOI : 10.1126/science.1165706

T. Flynn, Review of the bookDesign and Analysis of Cluster Randomization Trials in, Health Research Int J Epidemiol, pp.407-415, 2001.

. Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand. The Journal of infectious diseases, pp.1661-71, 2006.

S. Buchbinder, D. Mehrotra, A. Duerr, D. Fitzgerald, R. Mogg et al., Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial, The Lancet, vol.372, issue.9653, pp.1881-93, 2008.
DOI : 10.1016/S0140-6736(08)61591-3

G. Gray, M. Allen, Z. Moodie, G. Churchyard, L. Bekker et al., Safety and efficacy of the HVTN 503/Phambili Study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study, The Lancet Infectious Diseases, vol.11, issue.7, pp.507-522, 2011.
DOI : 10.1016/S1473-3099(11)70098-6

C. No, Available from: https://www.niaid.nih.gov/news-events/nih-discontinues- immunizations-hiv-vaccine-study, 2017.

. South-african-medical-research and . Council, Summarative review of the annual report for the South African Research Council (SAMRC) for the financial period 2014-2015, Available, vol.from, 2015.

. South-african-medical-research and . Council, Strategic Health Innovation Partnerships project awards 2013-2017. 2017 Available from: http://ship.mrc.ac.za/funding.htm [Access date, pp.2017-2026

J. Bryant, L. Baxter, and S. Hird, Non-occupational postexposure prophylaxis for HIV: a systematic review. Health technology assessment, Feb, vol.13, issue.14, pp.1-60, 2009.
DOI : 10.3310/hta13140
URL : https://njl-admin.nihr.ac.uk/document/download/2001727

J. Kim, L. Martin, and L. Denny, Rape and HIV post-exposure prophylaxis: addressing the dual epidemics in South Africa. Reproductive health matters, pp.101-113, 2003.

M. Moorhouse, L. Bekker, V. Black, F. Conradie, B. Harley et al., Guideline on the management of occupational and non-occupational exposure to the human immunodeficiency virus and recommendations for post-exposure prophylaxis, pp.2015-2015

L. Makhado and M. Davhana-maselesele, Knowledge and uptake of occupational post-exposure prophylaxis amongst nurses caring for people living with HIV. Curationis, p.1593, 2016.

A. Karim, Q. , A. Karim, S. Frohlich, J. Grobler et al., Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women, Science, vol.199, issue.7, pp.1168-74, 2019.
DOI : 10.1086/597276

R. Grant, J. Lama, P. Anderson, V. Mcmahan, A. Liu et al., Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men, New England Journal of Medicine, vol.363, issue.27, pp.2587-99, 2010.
DOI : 10.1056/NEJMoa1011205

J. Baeten, D. Donnell, P. Ndase, N. Mugo, J. Campbell et al., Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women, New England Journal of Medicine, vol.367, issue.5, pp.399-410, 2012.
DOI : 10.1056/NEJMoa1108524

S. Mccormack, D. Dunn, M. Desai, D. Dolling, M. Gafos et al., Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial, The Lancet, vol.387, issue.10013, pp.53-60, 2016.
DOI : 10.1016/S0140-6736(15)00056-2

J. Molina, C. Capitant, B. Spire, G. Pialoux, L. Cotte et al., On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection, New England Journal of Medicine, vol.373, issue.23, pp.2237-2283, 2015.
DOI : 10.1056/NEJMoa1506273
URL : https://hal.archives-ouvertes.fr/halshs-01429281

L. Bekker, S. Roux, E. Sebastien, N. Yola, K. Amico et al., Daily and non-daily pre-exposure prophylaxis in African women (HPTN 067/ADAPT Cape Town Trial): a randomised, open-label, phase 2 trial, The Lancet HIV, vol.5, issue.2, 2017.
DOI : 10.1016/S2352-3018(17)30156-X

L. Van-damme, A. Corneli, K. Ahmed, K. Agot, J. Lombaard et al., Preexposure prophylaxis for HIV infection among African women. The New England journal of medicine, pp.411-433, 2012.

J. Marrazzo, G. Ramjee, B. Richardson, K. Gomez, N. Mgodi et al., Tenofovir-based preexposure prophylaxis for HIV infection among African women, Feb, vol.05372, issue.6, pp.509-527, 2015.

C. Spinner, C. Boesecke, A. Zink, H. Jessen, H. Stellbrink et al., HIV preexposure prophylaxis (PrEP): a review of current knowledge of oral systemic HIV PrEP in humans, Infection. 2016, vol.44, issue.2, pp.151-159

C. Teasdale, B. Marais, and E. Abrams, HIV: prevention of mother-to-child transmission, BMJ clinical evidence, 2011.

P. Barron, Y. Pillay, T. Doherty, G. Sherman, D. Jackson et al., Eliminating mother-to-child HIV transmission in South Africa, Bulletin of the World Health Organization, vol.91, issue.1, pp.70-74, 2013.
DOI : 10.2471/BLT.12.106807

A. Anglemyer, G. Rutherford, T. Horvath, R. Baggaley, M. Egger et al., Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples. The Cochrane database of systematic reviews, p.9153, 2013.

R. Baggaley, R. White, T. Hollingsworth, and M. Boily, Heterosexual HIV-1 Infectiousness and Antiretroviral Use, Epidemiology, vol.24, issue.1, p.2013
DOI : 10.1097/EDE.0b013e318276cad7
URL : http://europepmc.org/articles/pmc4312663?pdf=render

P. Vernazza, B. Hirschel, E. Bernasconi, and M. Flepp, Les personnes séropositives ne souffrant d'aucune autre MST et suivant un traitement antirétroviral efficace ne transmettent pas le VIH par voie sexuelle, Bull Med Suisse, vol.89, pp.165-174, 2008.

A. Motsoaledi, Budget Speech of the South African Department of Health for 2016/17 Financial Year, 2016.

J. Hontelez, S. De-vlas, F. Tanser, R. Bakker, T. Barnighausen et al., The Impact of the New WHO Antiretroviral Treatment Guidelines on HIV Epidemic Dynamics and Cost in South Africa, PLoS ONE, vol.3, issue.Suppl, p.21919, 2011.
DOI : 10.1371/journal.pone.0021919.s001

J. Montaner, V. Lima, R. Barrios, B. Yip, E. Wood et al., Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study, The Lancet, vol.376, issue.9740, pp.532-541, 2010.
DOI : 10.1016/S0140-6736(10)60936-1

M. Das, P. Chu, G. Santos, S. Scheer, E. Vittinghoff et al., Decreases in community viral load are accompanied by reductions in new HIV infections in San Francisco. PloS one, p.11068, 2010.

C. Fang, H. Hsu, S. Twu, M. Chen, Y. Chang et al., Decreased HIV transmission after a policy of providing free access to highly active antiretroviral therapy in Taiwan. The Journal of infectious diseases, pp.879-85, 2004.

V. Gill, V. Lima, W. Zhang, B. Wynhoven, B. Yip et al., Improved virological outcomes in British Columbia concomitant with decreasing incidence of HIV type 1 drug resistance detection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, pp.98-105, 2010.

A. Phillips, V. Cambiano, F. Nakagawa, A. Brown, F. Lampe et al., Increased HIV Incidence in Men Who Have Sex with Men Despite High Levels of ART-Induced Viral Suppression: Analysis of an Extensively Documented Epidemic, PLoS ONE, vol.35, issue.4, p.55312, 2013.
DOI : 10.1371/journal.pone.0055312.s002

A. Van-sighem, I. Jansen, D. Bezemer, D. Wolf, F. Prins et al., Increasing sexual risk behaviour among Dutch men who have sex with men, AIDS, vol.26, issue.14, pp.1840-1843, 2012.
DOI : 10.1097/QAD.0b013e3283574df9

H. Wand, P. Yan, D. Wilson, A. Mcdonald, M. Middleton et al., Increasing HIV transmission through male homosexual and heterosexual contact in Australia: results from an extended back-projection approach, HIV Medicine, vol.11, issue.6, pp.395-403, 2010.
DOI : 10.1111/j.1468-1293.2009.00804.x

A. Castel, M. Magnus, J. Peterson, K. Anand, C. Wu et al., Implementing a Novel Citywide Rapid HIV Testing Campaign in Washington, D.C.: Findings and Lessons Learned, Public Health Reports, vol.55, issue.14, pp.422-453, 1974.
DOI : 10.1371/journal.pone.0000185

J. Mossong, E. Grapsa, F. Tanser, T. Barnighausen, and M. Newell, Modelling HIV incidence and survival from age-specific seroprevalence after antiretroviral treatment scale-up in rural South Africa, AIDS, vol.27, issue.15, pp.2471-2480, 2013.
DOI : 10.1097/01.aids.0000432475.14992.da

R. Granich, J. Kahn, R. Bennett, C. Holmes, N. Garg et al., Expanding ART for Treatment and Prevention of HIV in South Africa: Estimated Cost and Cost-Effectiveness 2011-2050, PLoS ONE, vol.371, issue.17, p.30216, 2012.
DOI : 10.1371/journal.pone.0030216.s001

W. Miller, C. Lesko, and K. Powers, The HIV Care Cascade, Sexually Transmitted Diseases, vol.41, issue.1, pp.41-43, 2014.
DOI : 10.1097/OLQ.0000000000000081

N. Haber, F. Tanser, J. Bor, K. Naidu, T. Mutevedzi et al., From HIV infection to therapeutic response: a population-based longitudinal HIV cascade-of-care study in KwaZulu-Natal, South Africa, The Lancet HIV, vol.4, issue.5, 2017.
DOI : 10.1016/S2352-3018(16)30224-7

S. Rosen and P. Fox, Retention in HIV Care between Testing and Treatment in Sub-Saharan Africa: A Systematic Review, PLoS Medicine, vol.15, issue.7, 2011.
DOI : 10.1371/journal.pmed.1001056.s002

A. Raymond, A. Hill, and A. Pozniak, Large disparities in HIV treatment cascades between eight European and high-income countries - analysis of break points, Journal of the International AIDS Society, vol.173, issue.14, p.19507, 2014.
DOI : 10.1001/jamainternmed.2013.6841

H. Krentz, J. Macdonald, and M. Gill, The impact of transfer patients on the local cascade of HIV care continuum Journal of acquired immune deficiency syndromes, Feb, vol.0168, issue.2, pp.236-276, 2015.

J. Bor, A. Herbst, M. Newell, and T. Barnighausen, Increases in Adult Life Expectancy in Rural South Africa: Valuing the Scale-Up of HIV Treatment, Science, vol.88, issue.12, pp.961-966, 2013.
DOI : 10.2471/BLT.09.073890

M. Egger, M. May, G. Chêne, A. Phillips, B. Ledergerber et al., Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies, The Lancet, vol.360, issue.9327, pp.119-148, 2002.
DOI : 10.1016/S0140-6736(02)09411-4

M. Shah, K. Risher, S. Berry, and D. Dowdy, The Epidemiologic and Economic Impact of Improving HIV Testing, Linkage, and Retention in Care in the United States Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, pp.220-229, 2016.

G. Marks, N. Crepaz, J. Senterfitt, and R. Janssen, Meta-Analysis of High-Risk Sexual Behavior in Persons Aware and Unaware They are Infected With HIV in the United States, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.39, issue.4, pp.446-53, 2005.
DOI : 10.1097/01.qai.0000151079.33935.79

M. Mcnairy and W. El-sadr, Antiretroviral therapy for the prevention of HIV transmission: what will it take? Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, pp.1003-1014, 2014.

M. Musheke, H. Ntalasha, S. Gari, O. Mckenzie, V. Bond et al., A systematic review of qualitative findings on factors enabling and deterring uptake of HIV testing in Sub-Saharan Africa, BMC Public Health, vol.97, issue.46, p.220, 2013.
DOI : 10.2105/AJPH.2006.096263

S. Krishnaratne, B. Hensen, J. Cordes, J. Enstone, and J. Hargreaves, Interventions to strengthen the HIV prevention cascade: a systematic review of reviews, The Lancet HIV, vol.3, issue.7, pp.307-324, 2016.
DOI : 10.1016/S2352-3018(16)30038-8

L. Metsch, M. Pereyra, S. Messinger, D. Rio, C. Strathdee et al., HIV transmission risk behaviors among HIV-infected persons who are successfully linked to care. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2008.

K. Kranzer, D. Govindasamy, N. Ford, V. Johnston, and S. Lawn, Quantifying and addressing losses along the continuum of care for people living with HIV infection in sub-Saharan Africa: a systematic review, Journal of the International AIDS Society, vol.373, issue.2, p.17383, 2012.
DOI : 10.1016/S0140-6736(08)61697-9

D. Govindasamy, N. Ford, and K. Kranzer, Risk factors, barriers and facilitators for linkage to antiretroviral therapy care, AIDS, vol.26, issue.16, pp.2059-67, 2012.
DOI : 10.1097/QAD.0b013e3283578b9b

D. Donnell, J. Baeten, J. Kiarie, K. Thomas, W. Stevens et al., Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis, The Lancet, vol.375, issue.9731, pp.2092-2100, 2010.
DOI : 10.1016/S0140-6736(10)60705-2

N. Mccreesh, I. Andrianakis, R. Nsubuga, M. Strong, I. Vernon et al., Improving ART programme retention and viral suppression are key to maximising impact of treatment as prevention ??? a modelling study, BMC Infectious Diseases, vol.316, issue.2, p.557, 2017.
DOI : 10.1093/infdis/jiv430

R. Barth, M. Van-der-loeff, R. Schuurman, A. Hoepelman, and A. Wensing, Virological followup of adult patients in antiretroviral treatment programmes in sub-Saharan Africa: a systematic review. The Lancet Infectious diseases, pp.155-66, 2010.

E. Mills, J. Nachega, D. Bangsberg, S. Singh, B. Rachlis et al., Adherence to HAART: A Systematic Review of Developed and Developing Nation Patient-Reported Barriers and Facilitators, PLoS Medicine, vol.24, issue.11, p.438, 2006.
DOI : 10.1371/journal.pmed.0030438.t007

L. Mbuagbaw, B. Sivaramalingam, T. Navarro, N. Hobson, A. Keepanasseril et al., Interventions for Enhancing Adherence to Antiretroviral Therapy (ART): A Systematic Review of High Quality Studies. AIDS patient care and STDs, pp.248-66, 2015.

S. Takuva, A. Puren, A. Brown, V. Delpech, W. Macleod et al., Disparities in Engagement Within HIV Care in South Africa, CROI, 2015.

A. Grobler, C. Cawood, D. Khanyile, A. Puren, and A. Kharsany, Progress of UNAIDS 90-90-90 targets in a district in KwaZulu-Natal, South Africa, with high HIV burden, in the HIPSS study: a household-based complex multilevel community survey, The Lancet HIV, vol.4, issue.11, pp.505-518, 2017.
DOI : 10.1016/S2352-3018(17)30122-4

C. Iwuji, J. Orne-gliemann, E. Balestre, J. Larmarange, R. Thiebaut et al., The impact of universal test and treat on HIV incidence in a rural South African population: ANRS 12249 TasP trial, AIDS Conference Abstract Available from, pp.2012-2016, 2016.

M. Petersen, L. Balzer, and D. Kwarsiima, Association of Implementation of a Universal Testing and Treatment Intervention With HIV Diagnosis, Receipt of Antiretroviral Therapy, and Viral Suppression in East Africa, JAMA, vol.317, issue.21, pp.3172196-206, 2017.
DOI : 10.1001/jama.2017.5705

M. Mcnairy and W. El-sadr, The HIV care continuum, AIDS, vol.26, issue.14, pp.1735-1743, 2012.
DOI : 10.1097/QAD.0b013e328355d67b

B. Singh and J. Sachs, One Million Community Health Workers, p.2016

D. Frymus, M. Kok, D. Koning, K. Quain, and E. , Global Health Workforce Alliance, World Health Organization. Community Health Workers and Universal Health Coverage: Knowledge gaps and aneed based Global Research agenda by 2015, Available from, p.2016, 2013.

G. Cometto, T. Boerma, J. Campbell, L. Dare, and T. Evans, The Third Global Forum: framing the health workforce agenda for universal health coverage. The Lancet Global health, pp.324-329, 2013.

R. Granich, B. Williams, J. Montaner, and J. Zuniga, 90-90-90 and ending AIDS: necessary and feasible, The Lancet, vol.390, issue.10092, pp.341-344, 2017.
DOI : 10.1016/S0140-6736(17)31872-X

A. Jones, I. Cremin, F. Abdullah, J. Idoko, P. Cherutich et al., Transformation of HIV from pandemic to low-endemic levels: a public health approach to combination prevention, The Lancet, vol.384, issue.9939, pp.272-281, 2014.
DOI : 10.1016/S0140-6736(13)62230-8

T. Bärnighausen, K. Chaiyachati, N. Chimbindi, A. Peoples, J. Haberer et al., Interventions to increase antiretroviral adherence in sub-Saharan Africa: a systematic review of evaluation studies, The Lancet Infectious Diseases, vol.11, issue.12, pp.942-51, 2011.
DOI : 10.1016/S1473-3099(11)70181-5

J. Haberer, L. Sabin, K. Amico, C. Orrell, O. Galarraga et al., Improving antiretroviral therapy adherence in resource-limited settings at scale: a discussion of interventions and recommendations, Journal of the International AIDS Society, vol.71, issue.4, p.21371, 2017.
DOI : 10.1093/jac/dkv425

D. Havlir, R. Bassett, and D. Levitan, Prevalence and Predictive Value of Intermittent Viremia With Combination HIV Therapy, JAMA, vol.286, issue.2, pp.171-180, 2001.
DOI : 10.1001/jama.286.2.171

J. Kahn, N. Muraguri, B. Harris, E. Lugada, T. Clasen et al., Integrated HIV Testing, Malaria, and Diarrhea Prevention Campaign in Kenya: Modeled Health Impact and Cost-Effectiveness, PLoS ONE, vol.107, issue.2, p.31316, 2012.
DOI : 10.1371/journal.pone.0031316.s002