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Rôle d’une réponse hormonale glucocorticoïde dans le contrôle de la plasticité des cellules cancéreuses mammaires

Abstract : Cancer cells with stemness properties - generally designated cancer stem cells (CSCs) - are at the apex of the hierarchical organisation of tumours and are believed to drive tumour recurrence and metastasis formation. However, how they perform these neoplastic activities in a nutritive environment that is distinct from the one in an established tumour is unknown. Here, we unveil the prominent role of glucocorticoid activity in the control of mammary cancer cell plasticity and the induction of metabolic pliancy necessary for the tumorigenic potential of CSCs. By regulating MAFB-dependent cell reprogramming, glucocorticoids control stemness traits in malignant epithelial cells. As an integral part of this regulation, glucocorticoids activate the hexosamine biosynthetic pathway and rewire the metabolism of CSCs. The anabolic efficiency of these cells increases then, fostering tumour and metastasis development. Together, our findings suggest that inhibition of glucocorticoid metabolic activity could be an original strategy for CSC eradication and tumour treatment
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https://tel.archives-ouvertes.fr/tel-01767224
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Submitted on : Monday, April 16, 2018 - 1:01:14 AM
Last modification on : Friday, October 23, 2020 - 5:04:31 PM

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  • HAL Id : tel-01767224, version 1

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Ebticem Nouri. Rôle d’une réponse hormonale glucocorticoïde dans le contrôle de la plasticité des cellules cancéreuses mammaires. Cancer. Université de Lyon, 2017. Français. ⟨NNT : 2017LYSE1047⟩. ⟨tel-01767224⟩

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