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Disséquer la cascade métastatique par des approches innovantes d'imagerie cellulaire

Abstract : Metastasis can be considered as the end product of a multistep bio-mechano-chemical process where cancer cells disseminate to anatomically distant organs and home and establish themselves in a new tissue microenvironment. Although metastasis is the leading cause of cancer-related death, the main cellular mechanisms enabling this process remain to be elucidated. Importantly, the scientific community lacks adapted imaging technologies to accurately dissect, at the highest resolution possible, tumor cell behavior in vivo. Therefore, the main goal of my PhD thesis was to develop an intravital and non-invasive imaging approach to track tumor progression in the living mouse. This approach was included in the development of an intravital Correlative Light and Electron Microscopy protocol allowing to track tumor cells at different scales in their natural environment. It was used to study single invasive tumor cells in the mouse ear and brain and to describe the details of cell protrusions and cell-matrix interactions during invasion and intravasation of cancer cells.
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Submitted on : Wednesday, April 11, 2018 - 11:42:13 AM
Last modification on : Friday, October 23, 2020 - 5:03:15 PM

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  • HAL Id : tel-01763591, version 1

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Luc Mercier. Disséquer la cascade métastatique par des approches innovantes d'imagerie cellulaire. Cancer. Université de Strasbourg, 2017. Français. ⟨NNT : 2017STRAJ091⟩. ⟨tel-01763591⟩

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