Skip to Main content Skip to Navigation
Theses

Exposition de la population générale française aux allergènes de contact

Abstract : Skin sensitization is a public health issue in France and in the rest of Europe that can impact the life of the affected individual. A well-known cause of skin sensitization are the fragrance allergens present in cosmetics. The European cosmetic regulation in force to date requires the manufacturer to assess the risks of these substances prior to their placing on the market. Although some of these substances are also present in essential oils, there is currently no such regulation for these products. The aim of this work was to characterize the exposure to particular fragrance substances of interest due to the consumption of essential oils and cosmetics. At first, we studied the consumption of essential oils in a representative panel of the French population. Then, we defined the fragrance allergens found in these oils. We also defined dermal exposure to cosmetics. Finally, these data were crossed using probabilistic statistical methods (Monte-Carlo methods) to compare exposure to a particular allergen present in these two products: the limonene. This work permitted to demonstrate that essential oils can be a strong contributor in the global exposure to limonene, for particular body areas, e.g. face. This work therefore highlights the importance of taking into account essential oils, and not only cosmetics in the global exposure to particular contact allergens, in order to better protect the population.
Document type :
Theses
Complete list of metadatas

Cited literature [62 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-01760429
Contributor : Abes Star :  Contact
Submitted on : Friday, April 6, 2018 - 11:58:08 AM
Last modification on : Wednesday, September 16, 2020 - 9:57:16 AM

File

These-2017-BS-Biologie_sante-D...
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-01760429, version 1

Collections

Citation

Nicolas Dornic. Exposition de la population générale française aux allergènes de contact. Allergologie. Université de Bretagne occidentale - Brest, 2017. Français. ⟨NNT : 2017BRES0154⟩. ⟨tel-01760429⟩

Share

Metrics

Record views

3495

Files downloads

426