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Activation immunitaire, immuno-sénescence et inflammation : Analyses statistiques des liens avec les comorbidités non liées au VIH lors de l’infection par le VIH

Abstract : Antiretroviral therapies have improved the survival of HIV-infected people. However, many non-HIVrelated comorbidities occur and represent a major concern in patient care. Activation, inflammation and immunosenescence could play a major role in this process. Many markers can measure those dysfunctions and they are often used without accounting for their possible interdependency. The objectives of this thesis were i) proposing a combination of those markers, ii) assessing the association between the combination of markers and the presence of comorbidities and iii) assessing the association between the combination of markers and the risk of occurrence of comorbidities and mortality in HIV-infected patients included in the sub-study CIADIS from cohort ANRS CO3 Aquitaine. We identified two scores: the cellular and the soluble CIADIS scores. The cellular score was mostly to multimorbidity and occurrence of any kind of new comorbidity. The profile of underlying immune dysfunctions was different when looking separately at the comorbidities. These results support the assumption that several underlying profiles of activation, inflammation and senescence could be involved in the development of different comorbidities. Our results show that integrating new biomarkers in analyses could improve the understanding of comorbidities. We will continue to work on the identification of profiles of immune dysfunctions for some specific comorbidity.
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Submitted on : Tuesday, April 3, 2018 - 4:57:07 PM
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Alexandra Ozanne. Activation immunitaire, immuno-sénescence et inflammation : Analyses statistiques des liens avec les comorbidités non liées au VIH lors de l’infection par le VIH. Médecine humaine et pathologie. Université de Bordeaux, 2017. Français. ⟨NNT : 2017BORD0846⟩. ⟨tel-01757534⟩

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