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Optimisation automatique des incidences des faisceaux par l'algorithme du simplexe et optimisation des Contrôles qualité par la Maitrise Statistique des Processus (MSP) en Radiothérapie Conformationnelle par Modulation d'Intensité (RCMI)

Abstract : Intensity Modulated Radiation Therapy (IMRT) is currently considered as a technique of choice to increase the local control of the tumour while reducing the dose to surrounding organs at risk. However, its routine clinical implementation is partially held back by the excessive amount of work required to prepare the patient treatment. In order to increase the efficiency of the treatment preparation, two axes of work have been defined.
The first axis concerned the automatic optimisation of beam orientations. We integrated the simplex algorithm in the treatment planning system. Starting from the dosimetric objectives set by the user, it can automatically determine the optimal beam orientations that best cover the target volume while sparing organs at risk. In addition to time sparing, the simplex results of three patients with a cancer of the oropharynx, showed that the quality of the plan is also increased compared to a manual beam selection. Indeed, for an equivalent or even a better target coverage, it reduces the dose received by the organs at risk.
The second axis of work concerned the optimisation of pre-treatment quality control. We used an industrial method: Statistical Process Control (SPC) to retrospectively analyse the absolute dose quality control results performed using an ionisation chamber at Centre Alexis Vautrin (CAV). This study showed that SPC is an efficient method to reinforce treatment security using control charts. It also showed that our dose delivery process was stable and statistically capable for prostate treatments, which implies that a reduction of the number of controls can be considered for this type of treatment at the CAV.
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https://tel.archives-ouvertes.fr/tel-01748697
Contributor : Didier Wolf <>
Submitted on : Monday, December 1, 2008 - 1:36:06 PM
Last modification on : Friday, October 23, 2020 - 4:42:43 PM
Long-term archiving on: : Monday, June 7, 2010 - 11:38:11 PM

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  • HAL Id : tel-01748697, version 2

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Karine Gerard. Optimisation automatique des incidences des faisceaux par l'algorithme du simplexe et optimisation des Contrôles qualité par la Maitrise Statistique des Processus (MSP) en Radiothérapie Conformationnelle par Modulation d'Intensité (RCMI). Sciences de l'ingénieur [physics]. Institut National Polytechnique de Lorraine - INPL, 2008. Français. ⟨NNT : 2008INPL064N⟩. ⟨tel-01748697v2⟩

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