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The role of mechanosensitve ion channels during zebrafish heart regeneration

Abstract : In humans, most cardiovascular disorders lead to the destruction of cardiac tissue which will be replaced by fibrosis, leading to arrhythmia and reduced contractile function, resulting in an increase in ventricular load. In order to maintain an overall cardiac output, cardiomyocytes undergo hypertrophic response, leading to pathological hypertrophy and heart failure. This increase in ventricular load, have to be sensed by mechanosensors such as the mechanosensitive ion channels such as TREK-1. Unlike mammals, adult zebrafish (zf) can fully regenerate their heart after an extensive insult through cardiomyocyte dedifferentiation followed by proliferation. We believe that in adult mammals, cardiomyocyte proliferation has been blocked/inhibited. Therefore it’s likely that genes which respond to increased ventricular load in mammals and trigger pathological hypertrophy will trigger cardiomyocyte proliferation during heart regeneration in zf. In this study we show that zTREK1a and zTREK1b have similar biophysical and pharmacological properties to mammalian TREK1 and they are important for successful zebrafish heart regeneration.
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Submitted on : Thursday, March 29, 2018 - 11:17:08 AM
Last modification on : Tuesday, September 8, 2020 - 4:08:05 AM
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Nathalie Nasr. The role of mechanosensitve ion channels during zebrafish heart regeneration. Human health and pathology. Université Montpellier, 2018. English. ⟨NNT : 2018MONTT001⟩. ⟨tel-01748056⟩

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