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Coévolution dans le gène pol du VIH-1 : un carrefour aux frontières de nouvelles espèces du VIH

Abstract : Integrase (IN) is one of the viral enzymes ensuring HIV replication. The functionality of proteins, which, like those from HIV, have sequence variability, relies on nonconserved residues, in addition to the conserved amino acids between strains, which have an important role especially when they are part of coevolution networks. These networks can counteract the deleterious effect of a mutation by introducing compensatory mutations elsewhere in the protein. This work has demonstrated, through a comparative study of different strains of HIV, extensive coevolution networks in IN. A major result is the identification of a new motif that provides multiple roles in the infectious cycle. The pattern differs between HIV groups M and O, but is strictly conserved within these two groups despite some genetic flexibility in cell culture. This suggests that these groups followed convergent, although distinct, evolution pathways.
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Submitted on : Tuesday, March 27, 2018 - 3:46:09 PM
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  • HAL Id : tel-01744713, version 1

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Marine Kanja. Coévolution dans le gène pol du VIH-1 : un carrefour aux frontières de nouvelles espèces du VIH. Génomique, Transcriptomique et Protéomique [q-bio.GN]. Université de Strasbourg, 2017. Français. ⟨NNT : 2017STRAJ077⟩. ⟨tel-01744713⟩

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