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Obésité induite par un régime riche en lipides (HFD) et effet protecteur d'un extrait polyphénolique de raisin (GSSE) : approche protéomique

Abstract : The effects of GSSE (Grape seed and skin extract) extracted from grapes particularly rich in antioxidants have been studied to prevent metabolic and cardiovascular disorders related to obesity. Obesity is characterized by an ectopic accumulation of fat in non-adipose tissues such as the brain. This cerebral lipotoxicity induces chronic inflammation of the brain. In this work, using quantitative proteomic analysis, biochemical and bio-informatic tools allows us to identify actors of metabolic and biological pathways that were disregulated in brain of experimentally-induced obese rats and corrected by GSSE treatment. While our data are consistent with previous findings of obesity-induced brain lipotoxicity, such as enhancement of proteins belonging to the OXPHOS and calcium pathways, they also unveiled novel pathways including the up-regulation of HIF-signaling pathway in HFD brains. In the same context, GSSE abrogated HFD-induced signaling pathway elevation either by modulating several proteins or by inducing some others that were not affected by HFD
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https://tel.archives-ouvertes.fr/tel-01744396
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Submitted on : Tuesday, March 27, 2018 - 1:17:07 PM
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Selima Smine. Obésité induite par un régime riche en lipides (HFD) et effet protecteur d'un extrait polyphénolique de raisin (GSSE) : approche protéomique. Biochimie, Biologie Moléculaire. Normandie Université; Université de Tunis El Manar, 2017. Français. ⟨NNT : 2017NORMR111⟩. ⟨tel-01744396⟩

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