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Genotype-phenotype relationship exploration by genome-wide association studies in yeast

Abstract : Elucidating the genetic origin of phenotypic diversity among individuals within the same species is essential to understand evolution. Using whole genome sequences of 1,011 Saccharomyces cerevisiae isolates, my work sought to describe intraspecific genetic variation and investigate of its phenotypic consequences. Doing so, I obtained a precise view of the evolutionary history of S. cerevisiae. Phenotypic characterization provided the opportunity to perform genotype-phenotype genome-wide association studies with unprecedented power. I then focused on the evaluation of the parameters influencing genome-wide association studies, the appreciation of the limits of such an approach, and ways to circumvent them.
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https://tel.archives-ouvertes.fr/tel-01744210
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Submitted on : Tuesday, March 27, 2018 - 11:25:09 AM
Last modification on : Thursday, April 26, 2018 - 4:10:59 AM
Long-term archiving on: : Thursday, September 13, 2018 - 8:13:13 AM

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  • HAL Id : tel-01744210, version 1

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Jackson Peter. Genotype-phenotype relationship exploration by genome-wide association studies in yeast. Genomics [q-bio.GN]. Université de Strasbourg, 2017. English. ⟨NNT : 2017STRAJ064⟩. ⟨tel-01744210⟩

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