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Physiologie de l’exercice et métabolomique chez des athlètes exposés à une altitude modérée aiguë

Abstract : Although it is known that altitude impairs performance in endurance sports, there is no consensus on the involvement of energy substrates in this process. Some studies have shown an increased use of carbohydrates at altitude compared at plain but the intensities of exercises used are debatable and the use of traditional biochemical methods allowed to dose only a limited number of molecules. Today, thanks to metabolomics, it is possible to analyze the variations of a large number of metabolites simultaneously. The aim of this thesis is to investigate the incidence of moderate altitude on the use of energy substrates on stress using proton nuclear magnetic resonance metabolomics. Plasma and urine samples were collected during endurance exercises at plain and at moderate altitude in non-acclimatized subjects. Our first results in plasma showed decreased blood glucose and increased use of branched amino acids between before and after endurance exercise at altitude, which was not observed at plain. These results were then confirmed during an endurance exercise until exhaustion. Moreover, we have shown that the use of urine allows to highlight the results obtained in the plasmas, which is very encouraging for the understanding of the metabolic adaptations at altitude by noninvasive methods. Finally, we used an innovative statistical method called “ common components and specific weights analysis”. The results allowed us to observe the common variability between the measured physiological parameters and the variations of the plasma metabolites.
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Florian Messier. Physiologie de l’exercice et métabolomique chez des athlètes exposés à une altitude modérée aiguë. Médecine humaine et pathologie. Université de Perpignan, 2017. Français. ⟨NNT : 2017PERP0050⟩. ⟨tel-01743818⟩

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