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Caractérisation structurale et fonctionnelle des métabolites de l'algue verte Ulva Rigida au moyen d'une approche protéomique

Abstract : Natural molecules from different origins present a high therapeutic potential. Among them, molecules extracted from marine algae are particularly interesting. Several studies are currently being devoted to the isolation of new bioactive compounds from marine resources that have promising health benefits. Among the marine resources, the bioactive compounds present in many species of algae have particularly interesting nutritional and pharmaceutical properties. This thesis deals with the beneficial effects of the alga Ulva rigida. It relates more particularly to the activities of the protein extract of the green alga Ulva rigida. In this study, we studied the preventive effect of a protein extract (PE) of Ulva rigida against UVB-induced cell damage. We have demonstrated that treatment of cortical astrocytes with 50 μg of PE induces a strong glioprotective effect and suppresses the harmful effects of UVB radiation, in particular increasing cell viability. Other extra tests allowed us to say that this extract stimulates the activity of catalase and superoxide dismutase and inhibits the production of stress markers such as H2O2 or lipid peroxidation. Moreover, the proteolytic digestion or the heat treatment of the algal extract inhibited this preventive effect, arguing for the predominant role of the protein fraction. Subsequently, proteomic studies have identified several proteins in the extract, of which calmodulin has been shown to be an important contributor to the protective activities observed on both astrocyte and neuron cultures.
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Submitted on : Tuesday, March 20, 2018 - 5:08:20 PM
Last modification on : Thursday, July 2, 2020 - 3:29:14 AM
Long-term archiving on: : Tuesday, September 11, 2018 - 9:52:19 AM


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  • HAL Id : tel-01738707, version 1


Amel Zehlila. Caractérisation structurale et fonctionnelle des métabolites de l'algue verte Ulva Rigida au moyen d'une approche protéomique. Neurosciences [q-bio.NC]. Normandie Université; Université de Tunis El Manar, 2017. Français. ⟨NNT : 2017NORMR101⟩. ⟨tel-01738707⟩



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