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Role of neutrophils and leukotrienes in atherosclerotic plaque destabilisation : implication of endotoxemia

Abstract : Atherosclerotic plaque destabilisation remains an important issue, in spite of the recent advances in its comprehension. Neutrophils are powerful innate immune actors capable of altering plaques. In this context, the leukotriene B4, one of the main chemoattractants of neutrophils, has been proposed as a potential contributor to plaque destabilisation. A particular context in which these two actors are closely linked is endotoxemia, itself associated with plaque destabilisation This work was aimed at determining whether leukotriene B4 plays a role in the chemoattraction of neutrophils in plaques during endotoxemia and at assessing whether neutrophils can tip the balance which maintains plaques stable. We have herein evidenced that the recruitment of neutrophils mediated by leukotriene B4 has a deleterious impact upon plaque stability during endotoxemia by promoting apoptosis and degrading matrix fibres. In conclusion, this study paves the way to novel therapeutic approaches aimed at targeting the axis leukotriene-neutrophil in atherosclerotic disease.
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https://tel.archives-ouvertes.fr/tel-01737469
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Submitted on : Monday, March 19, 2018 - 2:59:06 PM
Last modification on : Friday, November 15, 2019 - 10:10:47 AM
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  • HAL Id : tel-01737469, version 1

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Marie-Anne Mawhin. Role of neutrophils and leukotrienes in atherosclerotic plaque destabilisation : implication of endotoxemia. Quantitative Methods [q-bio.QM]. Université de Strasbourg, 2017. English. ⟨NNT : 2017STRAJ034⟩. ⟨tel-01737469⟩

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