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Simulations Monte Carlo et étude théorique des dommages induits par les particules ionisantes à l’échelle macroscopique ainsi qu’à l’échelle moléculaire

Abstract : The work presented in this thesis can be placed in the context of biological damage simulation. Webegin with a macroscopic study where we question the relevance of absorbed-dose-based treatmentplanning. Then we move on to a micro-dosimetry study where we suggest the use of morebiologically relevant probes for damage, such as DNA strand breaks. More focus is given to thefundamental considerations on which the simulations are based, particularly the interaction crosssections. Due to the complexity of the biological medium, the interaction cross sections with waterare often used to simulate the behavior of particles. We develop a parallel user-friendly algorithmthat can provide the ionization cross sections for any molecular target, making use of particular toolsthat allow to overcome the computational difficulties, which makes our program particularlyinteresting for complex molecules. We provide preliminary results for water, ammonia, formic acidand Tetrahydrofuran.
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Submitted on : Wednesday, March 7, 2018 - 9:25:07 AM
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  • HAL Id : tel-01725081, version 1

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Lena Mouawad. Simulations Monte Carlo et étude théorique des dommages induits par les particules ionisantes à l’échelle macroscopique ainsi qu’à l’échelle moléculaire. Physique [physics]. Université de Strasbourg, 2017. Français. ⟨NNT : 2017STRAE009⟩. ⟨tel-01725081⟩

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