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Agrégation et séparation magnétique des nanoclusters magnétiques

Abstract : Magnetic separation has been gaining a new interest during two last decades thanks to emerging biomedical applications to cell or protein separation and immunoassays. This thesis is aimed at detailed exploration of magnetic nanoparticle separation in microfluidic scale enhanced by field-induce phase separation of nanoparticles. To this purpose, we synthesize superparamagnetic iron oxide nanoclusters of a size of 40-70 nm composed of numerous nanoparticles of a size 7-9 nm. We perform a detailed study of the kinetics of the field-induced phase separation of these nanoclusters as well as of their magnetic separation in microfluidic channels equipped with ordered arrays of magnetizable micropillars. The nanocluster aggregation rate is mostly governed by the dipolar coupling parameter and the nanocluster volume fraction, while the capture efficiency – by the Mason number. Molecular layers adsorbed on the nanocluster surface usually weaken magnetic interactions and decrease the capture efficiency, however, in some casesthey may induce attractive colloidal interactions and enhance the capture efficiency. The results of this work could be useful for development of magnetomicrofluidic immunoassays.
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Hinda Ezzaier. Agrégation et séparation magnétique des nanoclusters magnétiques. Autre [cond-mat.other]. Université Côte d'Azur; Université de Carthage (Tunisie), 2017. Français. ⟨NNT : 2017AZUR4107⟩. ⟨tel-01724394⟩

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