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Étude en neuro-imagerie multimodale du système dopaminergique et du système de récompense chez des patients psychiatriques

Abstract : This work focuses on the study of the neurobiological bases of psychiatric disorders using multimodal imaging, with a particular interest in the dopaminergic pathways and the reward system. Its primary objective is to establish, through Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI), a link between the dopaminergic system and the reward system from a functional and structural point of view in humans, and especially in patients with psychiatric disorders such as schizophrenia, cocaine addiction and depression. Numerous studies have demonstrated the concomitant existence of abnormalities affecting dopaminergic function and reward system in several mental disorders. However, understanding of the linkages between dopaminergic dysfunction and dysfunction of the reward circuit in psychiatric disorders remains limited. The main aims of this thesis are to improve knowledge about the pathophysiology of several mental disorders such as schizophrenia, addiction and depression, and to demonstrate the interest of both a dimensional approach and the use of multimodal imaging in psychiatric research, to explore the molecular level of functional neural networks. In perspective, this thesis supports the interest of brain imaging in clinical practice, as it could later clarify the diagnosis, predict response to treatments or follow the course of the disease.
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Submitted on : Friday, March 2, 2018 - 1:06:05 AM
Last modification on : Wednesday, October 14, 2020 - 3:41:53 AM
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  • HAL Id : tel-01721323, version 1


Manon Dubol. Étude en neuro-imagerie multimodale du système dopaminergique et du système de récompense chez des patients psychiatriques. Médecine humaine et pathologie. Université Paris-Saclay, 2017. Français. ⟨NNT : 2017SACLS477⟩. ⟨tel-01721323⟩



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