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Utilisation de la stratégie du cheval de Troie pour lutter contre Pseudomonas aeruginosa : synthèses et propriétés biologiques de conjugués sidérophores-antibiotiques

Abstract : Constant discovery of innovative therapeutic strategies against pathogenic bacteria is crucial. Iron is essential for bacterial proliferation since it is integrated in the active site of essential enzymes. Many pathogenic bacteria excrete low molecular weight secondary metabolites called siderophores in order to promote iron (III) acquisition. Transmembrane siderophore-dependent iron uptake systems can be used as gates by siderophore-antibiotic conjugates. In this context, we synthesized conjugates between analogs of pyochelin, aminochelin or azotochelin with oxazolidinones antibiotics. In this project many of the conjugation between vectors and antibiotics were the result of click chemistry reactions even the use of peptidic bonds was also explored. Synthesis and biological properties of conjugates and vectors are presented in this manuscript.
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Aurélie Paulen. Utilisation de la stratégie du cheval de Troie pour lutter contre Pseudomonas aeruginosa : synthèses et propriétés biologiques de conjugués sidérophores-antibiotiques. Chimie thérapeutique. Université de Strasbourg, 2017. Français. ⟨NNT : 2017STRAJ021⟩. ⟨tel-01720436⟩

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