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Diversité et fonctionnalité de « nouveaux types » de Heat Shock Protein-70 kDa chez les arthropodes

Abstract : The 70 kDa Heat Shock Proteins (HSP70) are considered the most conserved members of the HSP family. These molecular chaperones are primordial to living beings, because of their implications in many cellular pathways and the management of multiple environmental stress factors (e. g., temperature, pollutants, salinity, radiations). Widely used in ecology as a biomarker of environmental stress, the HSP70 family is also a privileged therapeutic target for neurodegenerative diseases and cancers. In the cytosol, a wide variety of HSP70 is observed in few model species (Drosophila, human, yeast). Nevertheless, the diversity of cytosolic HSP70 remains unclear amongst the Arthropoda phylum, especially within decapods. The diversity studies of cytosolic HSP70 were based on 735 sequences from 198 arthropod species, including 142 sequences from decapods obtained during this work. Molecular phylogeny analyses revealed at least three distinct groups of HSP70 within arthropods, comprising several unrecognised subdivisions. This study proposes a new classification and an evolutionary model of cytosolic HSP70 amongst the Arthropoda phylum. The expression profiles observed in each group lead to reconsider the HSP70 classification according to their constitutive (HSC70) or inducible (HSP70) features. The observed structural specificities of genes and proteins, relative to each form of HSP70, will probably have to be linked to distinct interactions with cochaperones or other co-factors.
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https://tel.archives-ouvertes.fr/tel-01718232
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  • HAL Id : tel-01718232, version 1

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Stéphane Baringou. Diversité et fonctionnalité de « nouveaux types » de Heat Shock Protein-70 kDa chez les arthropodes. Biologie animale. Université du Maine, 2016. Français. ⟨NNT : 2016LEMA1009⟩. ⟨tel-01718232⟩

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