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Investigation of Local and Global Hydrodynamics of a Dynamic Filtration Module (RVF Technology) for Intensification of Industrial Bioprocess

Abstract : This thesis focuses on the understanding and the control of dynamic interactions between physical and biological mechanisms considering an alternative membrane separation into industrial bioprocess. It aims to carry scientific knowledge related to the control of bioreaction considering complex hydrodynamics and retention-permeation locks specific to membrane separation. A dynamic filtration technology, called Rotating and Vibrating Filtration (RVF), was investigated. It consists of filtration cells in series including two flat disc membranes fixed onto porous substrates in the vicinity of a three-blade impeller attached to a central shaft. This simple mechanical device runs continuously and generates a high shear stress as well as a hydrodynamic perturbation in the narrow membrane-blade gap. Several scientific and technical locks motivating this work are to characterize and to quantify (i) the velocity fields locally and instantaneously, (2) the shear stresses at membrane surface and (3) the mechanical impact on microbial cells.To this end, experiments and numerical simulations have been performed to investigate the hydrodynamics at global and local scales under laminar and turbulent regimes with Newtonian fluids under biotic and abiotic environment. For global approach, investigation of Residence Time Distribution (RTD) and thermal balance was carried out and compared to the previous global study (power consumption and friction curves). Analytical study of distribution functions was conducted and statistical moments were calculated and discussed. A systemic analysis was used to describe the hydrodynamic behaviors of the RVF module. Combining Computational Fluid Dynamics (CFD) and RTD observations, it leads to demonstrate dysfunctioning conditions and area. For the local approach, Particle Image Velocimetry (PIV) was be carried out in both horizontal and vertical planes and compared to CFD simulation. PIV preliminary study was conducted with a trigger strategy to access through angle-resolved measurements to an averaged velocity field. PIV further study were performed with a non-trigger strategy and applied to Proper Orthogonal Decomposition (POD) analysis in order to identify the coherent structure of the flow by decomposing the organized and turbulent fluctuations. For the bioprocess application, an exploratory work characterized the effect of Dynamic Filtration on prokaryote cell population (Escherichia coli) by quantifying cell integrity or damage as a function of time and rotation speed during filtration process in turbulent regime.
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Submitted on : Tuesday, February 27, 2018 - 9:27:05 AM
Last modification on : Tuesday, March 17, 2020 - 3:08:41 AM
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  • HAL Id : tel-01718041, version 1


Xiaomin Xie. Investigation of Local and Global Hydrodynamics of a Dynamic Filtration Module (RVF Technology) for Intensification of Industrial Bioprocess. Fluids mechanics [physics.class-ph]. INSA de Toulouse, 2017. English. ⟨NNT : 2017ISAT0020⟩. ⟨tel-01718041⟩



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