Skip to Main content Skip to Navigation
Theses

Synthèse et caractérisation de bispidines, chélatants du 64Cu, en vue d’applications pour la tomographie à émission de positrons

Abstract : This PhD work aimed at developing new bispidine-based copper(II) chelating agents for applications in Positron Emission Tomography (PET). On one hand, 64Cu is a metallic radioisotope which possesses interesting properties for PET imaging and on the other hand, bispidines have a pre-organized and rigid structure. This property makes them good chelating agents for numerous transition metals, particularly copper(II). This work presents the development of a new bispidine-based ligand having a phosphonate pendant arm as well as the development of bispidines allowing the synthesis of new chelating agents for copper(II). The physico-chemical properties of the phosphonated bispidine were thoroughly studied by different techniques, showing that it would be adequat for PET applications. Radiolabeling experiments were also done in the presence of 64Cu for various bispidines and show the high potential of bispidine ligands for the complexation of 64Cu. Finally, several functionalization strategies were studied in order to get bifunctional chelates based on the phosphonated bispidines. This study proved the possibility to develop two bifunctional bispidines based on the phosphonated one and also it allowed us to develop two bifunctional bispidines as synthon for the synthesis of new families of bifunctional bispidines.
Document type :
Theses
Complete list of metadatas

Cited literature [89 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-01716376
Contributor : Abes Star :  Contact
Submitted on : Friday, February 23, 2018 - 3:41:35 PM
Last modification on : Saturday, June 6, 2020 - 3:25:39 AM
Long-term archiving on: : Friday, May 25, 2018 - 7:39:26 AM

File

Gillet_Raphael_2017_ED222.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-01716376, version 1

Collections

Citation

Raphaël Gillet. Synthèse et caractérisation de bispidines, chélatants du 64Cu, en vue d’applications pour la tomographie à émission de positrons. Autre. Université de Strasbourg, 2017. Français. ⟨NNT : 2017STRAF058⟩. ⟨tel-01716376⟩

Share

Metrics

Record views

150

Files downloads

200