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Développement d’un substrat SPRi/SERS pour des applications en détection moléculaire

Abstract : In this thesis, we briefly describe the techniques used, which are surface plasmon resonanceimaging (SPRi) and surface enhanced Raman scattering (SERS). The main goal of the Piranexproject in which the thesis is based is the development of a bimodal nanostructured biochipallowing the coupling of the two techniques SPRi and SERS. This bio-chip consists of a goldfilm over which we have deposited a square array of gold nanocylinders. A set of studies hasbeen carried out to characterize plasmonic properties of the biosensor in order to optimize theSERS signal. We have thus found that the emission of the signal was strongly anisotropic, due tothe excitation of the Bragg Mode and that the near field was mainly enhanced on the edges of thenanostructure. The properties were also compared with those of identical gratings depositeddirectly on a dielectric substrate. Subsequently a set of plasmonic and SERS studies were carriedout for aluminum, other plasmonic materials of interest. Finally, a detection protocol by SERS ofochratoxin based on an aptamer was developed and allowed the detection of ochratoxin with adetection threshold of 10 pM, well below the limit allowed by food regulatory agencies
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Submitted on : Thursday, February 22, 2018 - 5:09:05 PM
Last modification on : Saturday, February 15, 2020 - 2:04:06 AM
Long-term archiving on: : Wednesday, May 23, 2018 - 2:33:13 PM


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  • HAL Id : tel-01715477, version 1



Raymond Gillibert. Développement d’un substrat SPRi/SERS pour des applications en détection moléculaire. Autre [q-bio.OT]. Université Sorbonne Paris Cité, 2017. Français. ⟨NNT : 2017USPCD003⟩. ⟨tel-01715477⟩



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