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Imagerie préclinique multimodale chez le petit animal : qualification des instruments et des méthodes (IRM, µTDM et µTEMP)

Abstract : Preclinical imaging is mostly performed on mouse animal models (61%). It is a necessary step in preclinical research, in compliance the first two recommendations of the 3Rs rules (reduction, refinement and replacement). In order to give a biological significance to measurements extracted from in vivo-acquired mouse images, it is necessary to evaluate instruments performances but also experimental procedures involved. The qualification of apparatuses requires the use of specific phantoms while the evaluation of methods requires procedures tests on non-pathological animals before experimentations. The scope of this work was to develop tools and methods to qualify imaging instruments and in vivo procedures. The need for quantification in small animal imaging, leads us to consider preclinical imaging instruments as metrological tools; which means integrating measurement uncertainty into.
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https://tel.archives-ouvertes.fr/tel-01712311
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Submitted on : Monday, February 19, 2018 - 1:32:06 PM
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  • HAL Id : tel-01712311, version 1

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Jean-Philippe Dillenseger. Imagerie préclinique multimodale chez le petit animal : qualification des instruments et des méthodes (IRM, µTDM et µTEMP). Ingénierie biomédicale. Université de Strasbourg, 2017. Français. ⟨NNT : 2017STRAD026⟩. ⟨tel-01712311⟩

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