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Synthèse, Caractérisation et Activité biologique des complexes à base de thiosemicarbazone

Abstract : Thiosemicarbazide and 4-methylthiosemicarbazide react with benzaldehyde derivatives by condensation to give different thiosemicarbazone ligands. The latter conduct in ethanolic medium to various complexes by reacting with chlorides and / or bromidesof copper (II), nickel (II), zinc (II), cobalt (II) and cadmium (II). The structures of the ligands and their complexes have been determined mainly by crystallography and by infrared spectroscopy, as well as by elementary analyzes. The ligands are in thion form in solid form.The complexes obtained are either monodentate, mononuclear or polynuclear complexes with two sulfur atoms of the thiosemicarbazone group, such as the determination of the crystal structure has shown either bidentate complexes with coordination sites, imine nitrogen and sulfur of the thio group. Their antifungal properties have been tested against human pathogenic strains: Aspergillus fumigatus, Candida albicans, C. glabrata, C. tropicalis, C. krusei, C. parapsilosis and Exophiala dermatitidis. Only thecomplexes with cadmium exhibited significant activities against the fungal species studied and the thiosemicarbazone of p-dimethylaminobenzaldehyde ligand almost completely inhibited the growth of E. dermatitidis
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Amani Jaafar. Synthèse, Caractérisation et Activité biologique des complexes à base de thiosemicarbazone. Chimie inorganique. Université d'Angers, 2017. Français. ⟨NNT : 2017ANGE0011⟩. ⟨tel-01707126⟩

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