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Identification du connectome de l'aire 24 du cortex cingulaire antérieur dans le contexte du développement de phénotypes de type anxio-dépressif chez la souris : implication de la voie amygdalo-cingulaire

Abstract : The anterior cingulate cortex (ACC) is a prefrontal region located at the center of a network allowing the sharing of cognitive, motor, limbic and visceral information, placing it as an interesting target for the study of complex pathologies like mood disorders. To investigate these diseases in mice, we provided the complete connectome of each ACC areas by a tract-tracing approach. We demonstrated that the majority of structures constituting this connectome are reciprocally connected with the ACC and that some density and topographical connection specificities were observed among cingulate areas. These results potentially suggest some shared functions between cingulate areas, also completed by specific roles inherent to each area. Using this connectome, we demonstrated that the repeated activation of the amygdala projection to the ACC was able to induce anxiodepressive-like behaviors in naïve mice, by using optogenetics combined with behavioral tests. This study highlights for the first time the implication of a portion of the ACC connectome in the establishment of mood disorders.
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https://tel.archives-ouvertes.fr/tel-01706970
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Submitted on : Monday, February 12, 2018 - 2:06:06 PM
Last modification on : Wednesday, March 18, 2020 - 9:48:53 AM
Long-term archiving on: : Monday, May 7, 2018 - 3:26:19 PM

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Clémentine Fillinger. Identification du connectome de l'aire 24 du cortex cingulaire antérieur dans le contexte du développement de phénotypes de type anxio-dépressif chez la souris : implication de la voie amygdalo-cingulaire. Neurosciences [q-bio.NC]. Université de Strasbourg, 2017. Français. ⟨NNT : 2017STRAJ029⟩. ⟨tel-01706970⟩

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