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Rôle des gènes de polarité Dlg1 et Crb3 dans la géométrie de la myéline du nerf périphérique

Abstract : In the mammalian nervous system, the nerve conduction velocity depends on the myelin sheath. Myelin is produced by Schwann cells in the peripheral nervous system. The myelin sheath, together with the highly specialized nodes of Ranvier that are regulary arrayed along the myelinated fibers, is responsible for efficient and rapid propagation of action potentials along the nerve. Optimal conduction is obtained by adjusting the geometry (length and thickness) of the myelin sheath When I arrived in the laboratory, the team just showed the polarization of the myelinating Schwann cell ( mSC). We hypothesized then that cell polarity proteins are key players for the formation of the myelin sheath. Three complexes, well conserved among species, organize polarized cellular processes. In mammals, these complexes are aPKC/Par3/Par6, Pals1/Patj/Crb3 et Dlg1/Lgl/Scrib. Using an approch allowing the in vivo transduction of mSC, I investigate the relevance of Dlg1 and Crb3 in myelin formation. Changes in the myelin geometry is linked to several human neuropathies in the central and peripheral nervous system. This work highlights mechanisms which control correct myelin formation and allow designing strategies for their treatment.
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Submitted on : Friday, February 9, 2018 - 12:48:07 PM
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Laurent Cotter. Rôle des gènes de polarité Dlg1 et Crb3 dans la géométrie de la myéline du nerf périphérique. Neurosciences [q-bio.NC]. Université Montpellier, 2017. Français. ⟨NNT : 2017MONTT113⟩. ⟨tel-01705332⟩

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