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Theses

Hydroxytyrosol et effets santé : Nouvelles voies d’action via ses métabolites glucurono-conjugués

Abstract : Olive oil polyphenols are well-known to lower cardiovascular mortality and type 2 diabetes incidence associated to the Mediterranean diet. However, the high metabolization rate of hydroxytyrosol, the main phenolic compound of olive oil, into glucuronides, questions its real biological effect. The first objective of this thesis was to evidence the importance of glucuronides of Hydroxytyrosol in the enhancement of vascular function through antioxidative properties. It was found that, unlike to hydroxytyrosol that can be directly transported with bilitranslocase glucuronides have to be deconjugated by β-glucuronidase to exert their biological activity. A second objective was to evidence the effects of Hydroxytyrosol and glucuronides on vascular function in diet-induced metabolic syndrome rats. Neither hydroxytyrosol nor glucuronides modulated vascular function in this pathological context. A third objective was to show the effect of a chronic Hydroxytyrosol supplementation in refined olive oil on cardiovascular risk factors in a mice model of Metabolic Syndrome. Hydroxytyrosol supplementation was able to reduce weight gain, white adipose tissues mass and to lower blood pressure. These hypotensive effects seem to be due in smooth muscle cells function. In conclusion, our works highlight the importance of Hydroxytyrosol and its glucuronoconjugated metabolites, both contributing to the reduction of the incidence of cardiovascular risk factors associated to type 2 diabetes and Metabolic syndrome.
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https://tel.archives-ouvertes.fr/tel-01704541
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Submitted on : Thursday, February 8, 2018 - 3:14:07 PM
Last modification on : Tuesday, January 14, 2020 - 10:38:15 AM
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Julien Peyrol. Hydroxytyrosol et effets santé : Nouvelles voies d’action via ses métabolites glucurono-conjugués. Médecine humaine et pathologie. Université d'Avignon, 2017. Français. ⟨NNT : 2017AVIG0713⟩. ⟨tel-01704541⟩

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