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Etude de la virulence de Staphylococcus lugdunensis

Abstract : Staphylococcus lugdunensis is a coagulase negative staphylococcus species that may causes various infections of unusual severity. We conducted a translational study with a prospective clinical trial that aimed to describe S. lugdunensis infections and its real pathogenicity, associated with a systematic research of in vitro putative virulence factors. The final objective was to determine the statistical relationship between those two and find a putative real virulence factor. This trial was conducted between 2013 and 2016. It showed that S. lugdunensis displayed a high level of pathogenicity as 37.2% of all strains isolated came from infected patients and most of those infections were osteoarticular infections. We discovered a new protease that we named lugdulysin and that was strongly associated with osteoarticular infections. This secreted protein of 37 kDa was purified and sequenced, we characterized its chemical properties and the nucleotide environment of the coding sequence. We also achieved de novo sequencing of 7 strains of S. lugdunensis and found that several mobile genetic elements belonged to the sequences as plasmids and prophages.
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  • HAL Id : tel-01704277, version 1

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Xavier Argemi. Etude de la virulence de Staphylococcus lugdunensis. Bactériologie. Université de Strasbourg, 2017. Français. ⟨NNT : 2017STRAJ024⟩. ⟨tel-01704277⟩

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