Y. Allory, S. Culine, and A. De-la-taille, Kidney Cancer Pathology in the New Context of Targeted Therapy, Pathobiology, vol.23, issue.2, pp.90-98, 2011.
DOI : 10.1200/JCO.2005.05.179

URL : https://hal.archives-ouvertes.fr/inserm-00607855

A. Alt, S. Boorjian, C. Lohse, B. Costello, B. Leibovich et al., Survival after complete surgical resection of multiple metastases from renal cell carcinoma. Cancer, pp.2873-82, 2011.

T. Aoyama, J. Peters, N. Iritani, T. Nakajima, K. Furihata et al., Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha), J Biol Chem, 1998.

A. Bader, D. Brown, and M. Winkler, The promise of microRNA replacement therapy. Cancer Res, pp.7027-7057, 2010.

D. Baillat and R. Shiekhattar, Functional Dissection of the Human TNRC6 (GW182-Related) Family of Proteins, Molecular and Cellular Biology, vol.29, issue.15, pp.4144-55, 2009.
DOI : 10.1128/MCB.00380-09

I. Behm-ansmant, J. Rehwinkel, T. Doerks, A. Stark, P. Bork et al., mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes, Genes & Development, vol.20, issue.14, pp.1885-98, 2006.
DOI : 10.1101/gad.1424106

URL : http://genesdev.cshlp.org/content/20/14/1885.full.pdf

A. Bera, F. Das, N. Ghosh-choudhury, B. Kasinath, H. Abboud et al., microRNA-21-induced dissociation of PDCD4 from rictor contributes to Akt-IKK??-mTORC1 axis to regulate renal cancer cell invasion, Experimental Cell Research, vol.328, issue.1, pp.99-117, 2014.
DOI : 10.1016/j.yexcr.2014.06.022

A. Ghosh-choudhury, N. Dey, N. Das, F. Kasinath, B. Abboud et al., NF?Bmediated cyclin D1 expression by microRNA-21 influences renal cancer cell proliferation. Cell Signal, pp.2575-86, 2013.

J. Berger and D. Moller, The Mechanisms of Action of PPARs, Annual Review of Medicine, vol.53, issue.1, pp.409-444, 2002.
DOI : 10.1146/annurev.med.53.082901.104018

J. Berkers, O. Govaere, P. Wolter, B. Beuselinck, P. Schöffski et al., A Possible Role for MicroRNA-141 Down-Regulation in Sunitinib Resistant Metastatic Clear Cell Renal Cell Carcinoma Through Induction of Epithelial-to-Mesenchymal Transition and Hypoxia Resistance, The Journal of Urology, vol.189, issue.5, pp.1930-1938, 2013.
DOI : 10.1016/j.juro.2012.11.133

E. Birney, J. Stamatoyannopoulos, A. Dutta, R. Guigó, T. Gingeras et al., Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project, Nature, vol.12, issue.7146, pp.799-816, 2007.
DOI : 10.1093/oxfordjournals.molbev.a004169

C. Blanquart, O. Barbier, J. Fruchart, B. Staels, and C. Glineur, Peroxisome proliferatoractivated receptors: regulation of transcriptional activities and roles in inflammation, J Steroid Biochem Mol Biol, vol.85, pp.2-5267, 2003.

S. Bonovas, G. Nikolopoulos, and P. Bagos, Use of Fibrates and Cancer Risk: A Systematic Review and Meta-Analysis of 17 Long-Term Randomized Placebo-Controlled Trials, PLoS ONE, vol.7, issue.9, p.45259, 2012.
DOI : 10.1371/journal.pone.0045259.t004

G. Borchert, W. Lanier, and B. Davidson, RNA polymerase III transcribes human microRNAs, Nature Structural & Molecular Biology, vol.13, issue.12, pp.1097-101, 2006.
DOI : 10.1038/nsmb1141

A. Brunot, J. Dagher, C. Perrin, J. Patard, K. Bensalah et al., Le carcinome r??nal ?? cellules claires (CRCC) sans alt??ration du g??ne de Von Hippel???Lindau (VHL)??: une entit?? anatomo-clinique ?? part???, Progr??s en Urologie, vol.24, issue.13, p.835, 2014.
DOI : 10.1016/j.purol.2014.08.114

X. Cai, C. Hagedorn, and B. Cullen, Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs, RNA, vol.10, issue.12, 2004.
DOI : 10.1261/rna.7135204

G. Calin, C. Sevignani, C. Dumitru, T. Hyslop, E. Noch et al., Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers, Proceedings of the National Academy of Sciences, vol.39, issue.2, pp.2999-3004, 2004.
DOI : 10.1002/gcc.10316

URL : http://www.pnas.org/content/101/9/2999.full.pdf

J. Cao, J. Liu, R. Xu, X. Zhu, L. Liu et al., MicroRNA-21 stimulates epithelial-to-mesenchymal transition and tumorigenesis in clear cell renal cells, Molecular Medicine Reports, vol.13, issue.1, pp.75-82, 2016.
DOI : 10.3892/mmr.2015.4568

U. Capitanio, V. Cloutier, L. Zini, H. Isbarn, C. Jeldres et al., A critical assessment of the prognostic value of clear cell, papillary and chromophobe histological subtypes in renal cell carcinoma: a population-based study, BJU International, vol.51, issue.11, pp.1496-500, 2009.
DOI : 10.1111/j.1464-410X.2008.08259.x

URL : https://hal.archives-ouvertes.fr/inserm-00354593

T. Cech and J. Steitz, The Noncoding RNA Revolution???Trashing Old Rules to Forge New Ones, Cell, vol.157, issue.1, pp.77-94, 2014.
DOI : 10.1016/j.cell.2014.03.008

URL : https://doi.org/10.1016/j.cell.2014.03.008

J. Chan, K. Blansit, T. Kiet, A. Sherman, G. Wong et al., The inhibition of miR-21 promotes apoptosis and chemosensitivity in ovarian cancer, Gynecologic Oncology, vol.132, issue.3, 2014.
DOI : 10.1016/j.ygyno.2014.01.034

C. Chen, D. Zheng, Z. Xia, and A. Shyu, Ago???TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps, Nature Structural & Molecular Biology, vol.59, issue.11, 2009.
DOI : 10.1093/emboj/17.12.3461

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921184/pdf

P. Chen, H. Manninga, K. Slanchev, M. Chien, J. Russo et al., The developmental miRNA profiles of zebrafish as determined by small RNA cloning, Genes & Development, vol.19, issue.11
DOI : 10.1101/gad.1310605

X. Chen, Y. Ba, L. Ma, X. Cai, Y. Yin et al., Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases, Cell Research, vol.25, issue.10, pp.997-1006, 2008.
DOI : 10.1073/pnas.0804549105

T. Chendrimada, K. Finn, J. X. Baillat, D. Gregory, R. Liebhaber et al., MicroRNA silencing through RISC recruitment of eIF6, Nature, vol.23, issue.7146, pp.823-831, 2007.
DOI : 10.1128/MCB.19.2.1416

Y. Cheng, X. Liu, S. Zhang, Y. Lin, Y. J. Zhang et al., MicroRNA-21 protects against the H2O2-induced injury on cardiac myocytes via its target gene PDCD4, Journal of Molecular and Cellular Cardiology, vol.47, issue.1, pp.5-14, 2009.
DOI : 10.1016/j.yjmcc.2009.01.008

P. Costa, A. Cardoso, C. Nóbrega, L. Pereira-de-almeida, J. Bruce et al., MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma, Human Molecular Genetics, vol.57, issue.Suppl. 4, pp.904-922, 2013.
DOI : 10.1046/j.1432-1327.2000.01606.x

P. Delerive, D. Bosscher, K. Besnard, S. , V. Berghe et al., Peroxisome Proliferator-activated Receptor ?? Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-??B and AP-1, Journal of Biological Chemistry, vol.91, issue.45, pp.32048-54, 1999.
DOI : 10.1073/pnas.95.5.2050

J. Deng, W. Lei, J. Fu, L. Zhang, J. Li et al., Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro, Biochemical and Biophysical Research Communications, vol.443, issue.3, pp.789-95, 2014.
DOI : 10.1016/j.bbrc.2013.11.064

A. Denli, B. Tops, R. Plasterk, R. Ketting, and G. Hannon, Processing of primary microRNAs by the Microprocessor complex, Nature, vol.432, issue.7014, pp.231-236, 2004.
DOI : 10.1016/0014-4827(86)90560-4

N. Dey, F. Das, N. Ghosh-choudhury, C. Mandal, D. Parekh et al., microRNA-21 Governs TORC1 Activation in Renal Cancer Cell Proliferation and Invasion, PLoS ONE, vol.55, issue.6, p.37366, 2012.
DOI : 10.1371/journal.pone.0037366.s025

URL : https://doi.org/10.1371/journal.pone.0037366

J. Doench and P. Sharp, Specificity of microRNA target selection in translational repression, Genes & Development, vol.18, issue.5, pp.504-515, 2004.
DOI : 10.1101/gad.1184404

C. Dreyer, M. Sablin, S. Faivre, and R. E. , Topics in mTOR pathway and its inhibitors]. Bull Cancer, pp.87-94, 2009.

J. Du, S. Yang, D. An, F. Hu, W. Yuan et al., BMP-6 inhibits microRNA-21 expression in breast cancer through repressing ??EF1 and AP-1, Cell Research, vol.7, issue.4, 2009.
DOI : 10.1089/104454904322745907

F. Glowacki, G. Savary, V. Gnemmi, D. Buob, C. Van-der-hauwaert et al., Increased Circulating miR-21 Levels Are Associated with Kidney Fibrosis, PLoS ONE, vol.25, issue.2, p.58014, 2013.
DOI : 10.1371/journal.pone.0058014.t002

URL : https://doi.org/10.1371/journal.pone.0058014

J. Gnarra, K. Tory, Y. Weng, L. Schmidt, M. Wei et al., Mutations of the VHL tumour suppressor gene in renal carcinoma, Nature Genetics, vol.88, issue.1, pp.85-90, 1994.
DOI : 10.7326/0003-4819-118-2-199301150-00005

I. Gomez, D. Mackenna, B. Johnson, V. Kaimal, A. Roach et al., Anti???microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways, Journal of Clinical Investigation, vol.125, issue.1, pp.141-56, 2015.
DOI : 10.1172/JCI75852DS1

URL : http://www.jci.org/articles/view/75852/files/pdf

M. Grabacka, M. Pierzchalska, and K. Reiss, Peroxisome Proliferator Activated Receptor ?? Ligands as Anticancer Drugs Targeting Mitochondrial Metabolism, Current Pharmaceutical Biotechnology, vol.14, issue.3, pp.342-56, 2013.
DOI : 10.2174/1389201011314030009

URL : http://europepmc.org/articles/pmc3631438?pdf=render

M. Grabacka, P. Plonka, K. Urbanska, and K. Reiss, Peroxisome Proliferator-Activated Receptor ?? Activation Decreases Metastatic Potential of Melanoma Cells In vitro via Down-Regulation of Akt, Clinical Cancer Research, vol.12, issue.10, pp.3028-3064, 2006.
DOI : 10.1158/1078-0432.CCR-05-2556

R. Gregory, K. Yan, G. Amuthan, T. Chendrimada, B. Doratotaj et al., The Microprocessor complex mediates the genesis of microRNAs, Nature, vol.12, issue.7014, pp.235-275, 2004.
DOI : 10.1038/nature03120

S. Griffiths-jones, R. Grocock, S. Van-dongen, A. Bateman, and A. Enright, miRBase: microRNA sequences, targets and gene nomenclature, Nucleic Acids Research, vol.34, issue.90001, pp.140-144, 2006.
DOI : 10.1093/nar/gkj112

URL : https://academic.oup.com/nar/article-pdf/34/suppl_1/D140/3925498/gkj112.pdf

S. Griffiths-jones, H. Saini, S. Van-dongen, and A. Enright, miRBase: tools for microRNA genomics, Nucleic Acids Research, vol.21, issue.5, pp.154-158, 2008.
DOI : 10.1093/bioinformatics/bth437

URL : https://academic.oup.com/nar/article-pdf/36/suppl_1/D154/7635053/gkm952.pdf

T. Gutschner and S. Diederichs, The hallmarks of cancer, RNA Biology, vol.1576, issue.6, pp.703-722
DOI : 10.1073/pnas.0600745103

J. Han, Y. Lee, K. Yeom, Y. Kim, J. H. Kim et al., The Drosha-DGCR8 complex in primary microRNA processing, Genes & Development, vol.18, issue.24, pp.3016-3043, 2004.
DOI : 10.1101/gad.1262504

M. Hatley, D. Patrick, M. Garcia, J. Richardson, R. Bassel-duby et al., Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21. Cancer Cell, pp.282-93, 2010.

T. Hayashi, N. Koyama, Y. Azuma, and M. Kashimata, Mesenchymal miR-21 regulates branching morphogenesis in murine submandibular gland in vitro, Developmental Biology, vol.352, issue.2, pp.299-307, 2011.
DOI : 10.1016/j.ydbio.2011.01.030

J. Höck, L. Weinmann, C. Ender, S. Rüdel, E. Kremmer et al., Proteomic and functional analysis of Argonaute-containing mRNA???protein complexes in human cells, EMBO reports, vol.4, issue.11, pp.1052-60, 2007.
DOI : 10.1126/science.1111444

M. Hora, O. Hes, T. Reischig, T. Urge, J. Klecka et al., Tumours in End-Stage Kidney, Transplantation Proceedings, vol.40, issue.10, pp.3354-3362, 2008.
DOI : 10.1016/j.transproceed.2008.08.135

J. Hunt, O. Van-der-hel, G. Mcmillan, P. Boffetta, and P. Brennan, Renal cell carcinoma in relation to cigarette smoking: Meta-analysis of 24 studies, International Journal of Cancer, vol.128, issue.1, pp.101-109, 2005.
DOI : 10.1093/oxfordjournals.bmb.a011531

E. Huntzinger and E. Izaurralde, Gene silencing by microRNAs: contributions of translational repression and mRNA decay, Nature Reviews Genetics, vol.457, issue.2, pp.99-110, 2011.
DOI : 10.1038/nature07755

C. Ibáñez-ventoso, M. Vora, and M. Driscoll, Sequence Relationships among C. elegans, D. melanogaster and Human microRNAs Highlight the Extensive Conservation of microRNAs in Biology, PLoS ONE, vol.25, issue.7, p.2818, 2008.
DOI : 10.1371/journal.pone.0002818.s019

F. Islam, B. Qiao, R. Smith, V. Gopalan, and A. Lam, Cancer stem cell: Fundamental experimental pathological concepts and updates. Experimental and Molecular Pathology, pp.184-91, 2015.
DOI : 10.1016/j.yexmp.2015.02.002

E. Jonasch, Kidney Cancer: Current and Novel Treatment Options, Journal of the National Comprehensive Cancer Network, vol.13, issue.5S, pp.679-81, 2015.
DOI : 10.6004/jnccn.2015.0202

K. Kida, M. Nakajima, T. Mohri, Y. Oda, S. Takagi et al., PPAR?? Is Regulated by miR-21 and miR-27b in Human Liver, Pharmaceutical Research, vol.583, issue.4, pp.2467-76, 2011.
DOI : 10.1016/j.febslet.2009.01.034

H. Kim, A. Belldegrun, D. Freitas, M. Bui, K. Han et al., Paraneoplastic Signs and Symptoms of Renal Cell Carcinoma: Implications for Prognosis, The Journal of Urology, vol.170, issue.5, 2003.
DOI : 10.1097/01.ju.0000092764.81308.6a

K. Kim, Y. Lee, and R. Carthew, Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes. RNA, pp.22-31, 2007.

V. Kim, J. Han, and M. Siomi, Biogenesis of small RNAs in animals, Nature Reviews Molecular Cell Biology, vol.274, issue.2, pp.126-165, 2009.
DOI : 10.4161/rna.1.1.943

K. Kondo and W. Kaelin, The von Hippel???Lindau Tumor Suppressor Gene, Experimental Cell Research, vol.264, issue.1, pp.117-142, 2001.
DOI : 10.1006/excr.2000.5139

C. Kuhn and L. Joshua-tor, Eukaryotic Argonautes come into focus, Trends in Biochemical Sciences, vol.38, issue.5, pp.263-71, 2013.
DOI : 10.1016/j.tibs.2013.02.008

P. Kwak and Y. Tomari, The N domain of Argonaute drives duplex unwinding during RISC assembly, Nature Structural & Molecular Biology, vol.725, issue.2, pp.145-51, 2012.
DOI : 10.1007/978-1-61779-046-1_7

R. Lee, R. Feinbaum, and A. V. , The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell, pp.843-54, 1993.
URL : https://hal.archives-ouvertes.fr/in2p3-00597159

Y. Lee, K. Jeon, J. Lee, S. Kim, and V. Kim, MicroRNA maturation: stepwise processing and subcellular localization, The EMBO Journal, vol.21, issue.17, pp.4663-70, 2002.
DOI : 10.1093/emboj/cdf476

URL : http://emboj.embopress.org/content/embojnl/21/17/4663.full.pdf

Y. Lee, M. Kim, J. Han, K. Yeom, S. Lee et al., MicroRNA genes are transcribed by RNA polymerase II, The EMBO Journal, vol.13, issue.20, pp.4051-60, 2004.
DOI : 10.1016/S1097-2765(02)00541-5

URL : http://emboj.embopress.org/content/embojnl/23/20/4051.full.pdf

H. Ling, M. Fabbri, and G. Calin, MicroRNAs and other non-coding RNAs as targets for anticancer drug development, Nature Reviews Drug Discovery, vol.430, issue.11, pp.847-65, 2013.
DOI : 10.1038/430161a

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548803/pdf

M. Ling, Y. Li, Y. Xu, Y. Pang, L. Shen et al., Regulation of miRNA-21 by reactive oxygen species-activated ERK/NF-?B in arsenite-induced cell transformation. Free Radical Biology and Medicine, pp.1508-1526, 2012.

J. Liu, M. Carmell, F. Rivas, C. Marsden, J. Thomson et al., Argonaute2 Is the Catalytic Engine of Mammalian RNAi, Science, vol.305, issue.5689, pp.1437-1478, 2004.
DOI : 10.1126/science.1102513

B. Ljungberg, S. Campbell, H. Choi, H. Cho, D. Jacqmin et al., The Epidemiology of Renal Cell Carcinoma, European Urology, vol.60, issue.4, pp.615-636, 2011.
DOI : 10.1016/j.eururo.2011.06.049

J. Lorenzen, H. Haller, and T. Thum, MicroRNAs as mediators and therapeutic targets in chronic kidney disease, Nature Reviews Nephrology, vol.11, issue.5, pp.286-94, 2011.
DOI : 10.2174/138945010791591403

T. Mace, A. Collins, S. Wojcik, C. Croce, G. Lesinski et al., Hypoxia induces the overexpression of MicroRNA-21 in pancreatic cancer cells. The Journal of surgical research, p.855, 2013.

I. Macrae, E. Ma, M. Zhou, C. Robinson, and J. Doudna, In vitro reconstitution of the human RISC-loading complex, Proceedings of the National Academy of Sciences, vol.13, issue.6, pp.512-519, 2008.
DOI : 10.1016/j.chembiol.2006.04.006

R. Madhyastha, H. Madhyastha, Y. Pengjam, Y. Nakajima, S. Omura et al., NFkappaB activation is essential for miR-21 induction by TGF??1 in high glucose conditions, Biochemical and Biophysical Research Communications, vol.451, issue.4, pp.615-636, 2014.
DOI : 10.1016/j.bbrc.2014.08.035

G. Mathonnet, M. Fabian, Y. Svitkin, A. Parsyan, L. Huck et al., MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F. Science, pp.1764-1771, 2007.

G. Meister, M. Landthaler, Y. Dorsett, and T. Tuschl, Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing, RNA, vol.10, issue.3, pp.544-50, 2004.
DOI : 10.1261/rna.5235104

G. Meister and T. Tuschl, Mechanisms of gene silencing by double-stranded RNA. Nature, pp.343-352, 2004.

F. Meng, R. Henson, H. Wehbe-janek, K. Ghoshal, S. Jacob et al., MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer, Gastroenterology, vol.133, issue.2, pp.647-58, 2007.
DOI : 10.1053/j.gastro.2007.05.022

M. Morlando, M. Ballarino, N. Gromak, F. Pagano, I. Bozzoni et al., Primary microRNA transcripts are processed co-transcriptionally, Nature Structural & Molecular Biology, vol.182, issue.9, 2008.
DOI : 10.1101/gr.229202. Article published online before March 2002

URL : http://www.nature.com/nsmb/journal/v15/n9/pdf/nsmb.1475.pdf

G. Mudduluru, J. George-william, S. Muppala, I. Asangani, R. Kumarswamy et al., Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cancer, Bioscience Reports, vol.15, issue.3, pp.185-97, 2011.
DOI : 10.1016/j.jmb.2008.03.015

URL : https://hal.archives-ouvertes.fr/hal-00558105

S. Nana-sinkam and C. Croce, Clinical Applications for microRNAs in Cancer, Clinical Pharmacology & Therapeutics, vol.51, issue.1, pp.98-104
DOI : 10.1126/science.1178178

C. Napoli, C. Lemieux, and R. Jorgensen, Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans. Plant Cell, pp.279-89, 1990.

U. Ørom, F. Nielsen, and A. Lund, MicroRNA-10a Binds the 5???UTR of Ribosomal Protein mRNAs and Enhances Their Translation, Molecular Cell, vol.30, issue.4, pp.460-71, 2008.
DOI : 10.1016/j.molcel.2008.05.001

S. Osanto, Y. Qin, H. Buermans, J. Berkers, E. Lerut et al., Genome-Wide MicroRNA Expression Analysis of Clear Cell Renal Cell Carcinoma by Next Generation Deep Sequencing, PLoS ONE, vol.10, issue.6, p.38298, 2012.
DOI : 10.1371/journal.pone.0038298.s006

F. Ozsolak, L. Poling, Z. Wang, H. Liu, X. Liu et al., Chromatin structure analyses identify miRNA promoters, Genes & Development, vol.22, issue.22, pp.3172-83, 2008.
DOI : 10.1101/gad.1706508

URL : http://genesdev.cshlp.org/content/22/22/3172.full.pdf

J. Park, E. Lee, C. Esau, and T. Schmittgen, Antisense Inhibition of microRNA-21 or -221 Arrests Cell Cycle, Induces Apoptosis, and Sensitizes the Effects of Gemcitabine in Pancreatic Adenocarcinoma, Pancreas, vol.38, issue.7, pp.190-199, 2009.
DOI : 10.1097/MPA.0b013e3181ba82e1

A. Pasquinelli, B. Reinhart, F. Slack, M. Martindale, M. Kuroda et al., Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA, Nature, vol.408, issue.6808, pp.86-95, 2000.

M. Passadouro, P. De-lima, M. Faneca, and H. , MicroRNA modulation combined with sunitinib as a novel therapeutic strategy for pancreatic cancer, Int J Nanomedicine, vol.9, pp.3203-3220, 2014.

J. Patard, E. Leray, A. Rodriguez, N. Rioux-leclercq, F. Guillé et al., Correlation between Symptom Graduation, Tumor Characteristics and Survival in Renal Cell Carcinoma, European Urology, vol.44, issue.2, pp.226-258, 2003.
DOI : 10.1016/S0302-2838(03)00216-1

M. Pawlak, P. Lefebvre, and B. Staels, Molecular mechanism of PPAR?? action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease, Journal of Hepatology, vol.62, issue.3, pp.720-753
DOI : 10.1016/j.jhep.2014.10.039

L. Peters and G. Meister, Argonaute proteins: mediators of RNA silencing. Mol Cell, 2007.

C. Petersen, M. Bordeleau, J. Pelletier, and P. Sharp, Short RNAs Repress Translation after Initiation in Mammalian Cells, Molecular Cell, vol.21, issue.4, pp.533-575, 2006.
DOI : 10.1016/j.molcel.2006.01.031

URL : https://doi.org/10.1016/j.molcel.2006.01.031

D. Petillo, E. Kort, J. Anema, K. Furge, X. Yang et al., MicroRNA profiling of human kidney cancer subtypes, International Journal of Oncology, vol.35, issue.01, pp.109-123, 2009.
DOI : 10.3892/ijo_00000318

R. Pillai, MicroRNA function: Multiple mechanisms for a tiny RNA?, RNA, vol.11, issue.12, 2005.
DOI : 10.1261/rna.2248605

M. Powers, K. Alvarez, H. Kim, and F. Monzon, Molecular Classification of Adult Renal Epithelial Neoplasms Using MicroRNA Expression and Virtual Karyotyping, Diagnostic Molecular Pathology, vol.20, issue.2, pp.63-70, 2011.
DOI : 10.1097/PDM.0b013e3181efe2a9

D. Pradella, C. Naro, C. Sette, and C. Ghigna, EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression, Molecular Cancer, vol.24, issue.1, p.8, 2017.
DOI : 10.1016/j.coph.2015.07.005

C. Prior, J. Perez-gracia, J. Garcia-donas, C. Rodriguez-antona, E. Guruceaga et al., Identification of Tissue microRNAs Predictive of Sunitinib Activity in Patients with Metastatic Renal Cell Carcinoma, PLoS ONE, vol.76, issue.1, p.86263, 2014.
DOI : 10.1371/journal.pone.0086263.s006

R. Ramachandra, M. Salem, S. Gahr, C. Rexroad, and J. Yao, Cloning and characterization of microRNAs from rainbow trout (Oncorhynchus mykiss): Their expression during early embryonic development, BMC Developmental Biology, vol.8, issue.1, p.41, 2008.
DOI : 10.1186/1471-213X-8-41

S. Ramanan, M. Kooshki, W. Zhao, F. Hsu, and M. Robbins, PPAR?? ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-??B and AP-1 pathways, Free Radical Biology and Medicine, vol.45, issue.12, pp.1695-704, 2008.
DOI : 10.1016/j.freeradbiomed.2008.09.002

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648135/pdf

J. Reddy, M. Rao, D. Azarnoff, and S. Sell, Mitogenic and carcinogenic effects of a hypolipidemic peroxisome proliferator, [4-chloro-6-(2,3-xylidino)-2- pyrimidinylthio]acetic acid (Wy-14, 643), in rat and mouse liver, Cancer Res, 1979.

M. Redova, A. Poprach, J. Nekvindova, R. Iliev, L. Radova et al., Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma, Journal of Translational Medicine, vol.10, issue.1, p.55, 2012.
DOI : 10.1183/09031936.00029610

B. Reinhart, F. Slack, M. Basson, A. Pasquinelli, J. Bettinger et al., The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans, Nature, vol.12, issue.6772, pp.901-907, 2000.
DOI : 10.1093/nar/12.1Part1.387

A. Rodriguez, S. Griffiths-jones, J. Ashurst, and A. Bradley, Identification of Mammalian microRNA Host Genes and Transcription Units, Genome Research, vol.14, issue.10a, pp.1902-1912, 2004.
DOI : 10.1101/gr.2722704

URL : http://genome.cshlp.org/content/14/10a/1902.full.pdf

M. Rui, Y. Qu, T. Gao, Y. Ge, C. Feng et al., Simultaneous delivery of anti-miR21 with doxorubicin prodrug by mimetic lipoprotein nanoparticles for synergistic effect against drug resistance in cancer cells, International Journal of Nanomedicine, vol.12, pp.217-254, 2017.
DOI : 10.2147/IJN.S122171

R. Rupaimoole and F. Slack, MicroRNA therapeutics: towards a new era for the management of cancer and other diseases, Nature Reviews Drug Discovery, vol.110, issue.3, 2017.
DOI : 10.1161/CIRCRESAHA.111.244442

H. Saini, S. Griffiths-jones, and A. Enright, Genomic analysis of human microRNA transcripts, Proceedings of the National Academy of Sciences, vol.34, issue.suppl_1, pp.17719-17743, 2007.
DOI : 10.1093/nar/gkj144

J. Sandlund, B. Ljungberg, P. Wikström, K. Grankvist, G. Lindh et al., Hypoxia-inducible factor-2?? mRNA expression in human renal cell carcinoma, Acta Oncologica, vol.48, issue.6, pp.909-923, 2009.
DOI : 10.1080/02841860902824891

URL : http://www.tandfonline.com/doi/pdf/10.1080/02841860902824891?needAccess=true

J. Sarkar, D. Gou, P. Turaka, E. Viktorova, R. Ramchandran et al., MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration, American Journal of Physiology-Lung Cellular and Molecular Physiology, vol.460, issue.6, pp.861-71, 2010.
DOI : 10.1038/cr.2008.24

K. Schoonjans, B. Staels, and J. Auwerx, The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol.1302, issue.2, pp.93-109, 1996.
DOI : 10.1016/0005-2760(96)00066-5

E. Scosyrev, E. Messing, and S. Campbell, Radical versus partial nephrectomy for a small renal mass: does saving nephrons save lives? Expert Review of Anticancer Therapy, pp.1349-51, 2013.

S. Selcuklu, M. Donoghue, and C. Spillane, as a key regulator of oncogenic processes, Biochemical Society Transactions, vol.37, issue.4, pp.918-943, 2009.
DOI : 10.1042/BST0370918

K. Shen, D. Cui, L. Sun, Y. Lu, M. Han et al., Inhibition of IGF-IR increases chemosensitivity in human colorectal cancer cells through MRP-2 promoter suppression, Journal of Cellular Biochemistry, vol.7, issue.6, pp.2086-97
DOI : 10.1016/j.canlet.2008.01.044

B. Shuch, L. Rochelle, J. Klatte, T. Riggs, S. Liu et al., Brain metastasis from renal cell carcinoma, Cancer, vol.17, issue.S, pp.1641-1649, 2008.
DOI : 10.4049/jimmunol.176.3.1456

S. Singh, M. Kagalwala, J. Parker-thornburg, H. Adams, and S. Majumder, REST maintains self-renewal and pluripotency of embryonic stem cells, Nature, vol.8, issue.7192, pp.223-230, 2008.
DOI : 10.4161/cc.5.17.2982

O. Slaby, J. Jancovicova, R. Lakomy, M. Svoboda, A. Poprach et al., Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy, Journal of Experimental & Clinical Cancer Research, vol.29, issue.1, p.90, 2010.
DOI : 10.1186/1756-9966-29-90

O. Slaby, M. Redova, A. Poprach, J. Nekvindova, R. Iliev et al., Identification of MicroRNAs associated with early relapse after nephrectomy in renal cell carcinoma patients, Genes, Chromosomes and Cancer, vol.32, issue.7, pp.707-723
DOI : 10.1093/carcin/bgq209

A. Slot, S. Molinski, and S. Cole, Mammalian multidrug-resistance proteins (MRPs), Essays In Biochemistry, vol.67
DOI : 10.1042/BJ20070292

URL : http://essays.biochemistry.org/content/ppebio/50/179.full.pdf

L. Sobin and C. Compton, TNM seventh edition: What's new, what's changed, Cancer, vol.104, issue.22, pp.5336-5345, 2010.
DOI : 10.1016/j.ijgo.2008.12.009

URL : http://onlinelibrary.wiley.com/doi/10.1002/cncr.25537/pdf

J. Song, J. Liu, N. Tolia, J. Schneiderman, S. Smith et al., The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes, Nature Structural & Molecular Biology, vol.11, issue.12, pp.1026-1058, 2003.
DOI : 10.1002/prot.340110407

S. Steffens, M. Janssen, F. Roos, F. Becker, S. Schumacher et al., Incidence and long-term prognosis of papillary compared to clear cell renal cell carcinoma ??? A multicentre study, European Journal of Cancer, vol.48, issue.15, pp.2347-52, 2012.
DOI : 10.1016/j.ejca.2012.05.002

J. Suda, D. Rockey, and S. Karvar, Akt2-Dependent Phosphorylation of Radixin in Regulation of Mrp-2 Trafficking in WIF-B Cells, Digestive Diseases and Sciences, vol.276, issue.2, pp.453-63, 2016.
DOI : 10.1074/jbc.M103900200

W. Sukov, C. Lohse, B. Leibovich, R. Thompson, and J. Cheville, Clinical and Pathological Features Associated With Prognosis in Patients With Papillary Renal Cell Carcinoma, The Journal of Urology, vol.187, issue.1, pp.54-63
DOI : 10.1016/j.juro.2011.09.053

R. Thermann and M. Hentze, Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation, Nature, vol.32, issue.7146, pp.875-883, 2007.
DOI : 10.1038/nature05878

D. Thomson, C. Bracken, and G. Goodall, Experimental strategies for microRNA target identification, Nucleic Acids Research, vol.29, issue.15, pp.6845-53, 2011.
DOI : 10.1038/onc.2010.59

URL : https://academic.oup.com/nar/article-pdf/39/16/6845/7188943/gkr330.pdf

K. Tsui, O. Shvarts, R. Smith, R. Figlin, J. Dekernion et al., PROGNOSTIC INDICATORS FOR RENAL CELL CARCINOMA:, The Journal of Urology, vol.163, issue.1295, pp.1090-1095, 2000.
DOI : 10.1097/00005392-200004000-00006

S. Vasudevan, Y. Tong, and J. Steitz, Switching from Repression to Activation: MicroRNAs Can Up-Regulate Translation, Science, vol.35, issue.7, pp.1931-1935, 2007.
DOI : 10.1093/nar/gkm133

S. Volinia, G. Calin, C. Liu, S. Ambs, A. Cimmino et al., A microRNA expression signature of human solid tumors defines cancer gene targets, Proceedings of the National Academy of Sciences, vol.99, issue.10, pp.2257-61, 2006.
DOI : 10.1073/pnas.082099299

M. Wakiyama, K. Takimoto, O. Ohara, and S. Yokoyama, Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system. Genes Dev, pp.1857-62, 2007.

B. Wang, T. Love, M. Call, J. Doench, and C. Novina, Recapitulation of Short RNA-Directed Translational Gene Silencing In Vitro, Molecular Cell, vol.22, issue.4, pp.553-60, 2006.
DOI : 10.1016/j.molcel.2006.03.034

B. Wang, A. Yanez, and C. Novina, MicroRNA-repressed mRNAs contain 40S but not 60S components, Proceedings of the National Academy of Sciences, vol.27, issue.11, pp.5343-5351, 2008.
DOI : 10.1021/bi00421a033

URL : http://www.pnas.org/content/105/14/5343.full.pdf

J. Weber, D. Baxter, S. Zhang, D. Huang, K. Huang et al., The MicroRNA Spectrum in 12 Body Fluids, Clinical Chemistry, vol.56, issue.11, pp.1733-1774, 2010.
DOI : 10.1373/clinchem.2010.147405

X. Wei, W. Wang, L. Wang, Y. Zhang, X. Zhang et al., MicroRNA-21 induces 5- fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4, Cancer Med. 2016, vol.5, issue.4, pp.693-702

S. Weikert, H. Boeing, T. Pischon, C. Weikert, A. Olsen et al., Blood Pressure and Risk of Renal Cell Carcinoma in the European Prospective Investigation into Cancer and Nutrition, American Journal of Epidemiology, vol.167, issue.4, pp.438-484, 2008.
DOI : 10.1093/aje/kwm321

J. Winter, S. Jung, S. Keller, R. Gregory, and S. Diederichs, Many roads to maturity: microRNA biogenesis pathways and their regulation, Nature Cell Biology, vol.11, issue.3, 2009.
DOI : 10.1126/science.1138050

Z. Wotschofsky, J. Liep, H. Meyer, M. Jung, I. Wagner et al., Identification of Metastamirs as Metastasis-associated MicroRNAs in Clear Cell Renal Cell Carcinomas, International Journal of Biological Sciences, vol.8, issue.10, pp.1363-74, 2012.
DOI : 10.7150/ijbs.5106

L. Wu, J. Fan, and J. Belasco, MicroRNAs direct rapid deadenylation of mRNA, Proceedings of the National Academy of Sciences, vol.115, issue.7, pp.4034-4043, 2006.
DOI : 10.1016/S0092-8674(03)01018-3

X. Wu, L. Weng, X. Li, C. Guo, S. Pal et al., Identification of a 4-microRNA Signature for Clear Cell Renal Cell Carcinoma Metastasis and Prognosis, PLoS ONE, vol.95, issue.5, pp.35661-114, 2012.
DOI : 10.1371/journal.pone.0035661.s001

R. Yi, Y. Qin, I. Macara, and B. Cullen, Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs, Genes & Development, vol.17, issue.24, pp.3011-3017, 2003.
DOI : 10.1101/gad.1158803

X. Yu, R. Li, W. Shi, T. Jiang, Y. Wang et al., Silencing of MicroRNA-21 confers the sensitivity to tamoxifen and fulvestrant by enhancing autophagic cell death through inhibition of the PI3K-AKT-mTOR pathway in breast cancer cells, Biomedicine & Pharmacotherapy, vol.77, pp.201637-201681
DOI : 10.1016/j.biopha.2015.11.005

Y. Yu, F. Sarkar, and A. Majumdar, Down-regulation of miR-21 Induces Differentiation of Chemoresistant Colon Cancer Cells and Enhances Susceptibility to Therapeutic Regimens, Translational Oncology, vol.6, issue.2, pp.180-186
DOI : 10.1593/tlo.12397

Y. Yuan, Y. Pei, J. Ma, V. Kuryavyi, M. Zhadina et al., Crystal Structure of A. aeolicus Argonaute, a Site-Specific DNA-Guided Endoribonuclease, Provides Insights into RISC-Mediated mRNA Cleavage, Molecular Cell, vol.19, issue.3, pp.405-424, 2005.
DOI : 10.1016/j.molcel.2005.07.011

M. Zaman, V. Shahryari, G. Deng, S. Thamminana, S. Saini et al., Up-Regulation of MicroRNA-21 Correlates with Lower Kidney Cancer Survival, PLoS ONE, vol.78, issue.2, p.31060, 2012.
DOI : 10.1371/journal.pone.0031060.s004

Y. Zeng and B. Cullen, Structural requirements for pre-microRNA binding and nuclear export by Exportin 5, Nucleic Acids Research, vol.32, issue.16, pp.4776-85, 2004.
DOI : 10.1093/nar/gkh824

URL : https://academic.oup.com/nar/article-pdf/32/16/4776/3375748/gkh824.pdf

A. Zhang, Y. Liu, Y. Shen, Y. Xu, and X. Li, miR-21 Modulates Cell Apoptosis by Targeting Multiple Genes in Renal Cell Carcinoma, Urology, vol.78, issue.2, pp.474-487, 2011.
DOI : 10.1016/j.urology.2011.03.030

H. Zhang, Y. Guo, C. Shang, Y. Song, and B. Wu, miR-21 Downregulated TCF21 to Inhibit KISS1 in Renal Cancer, Urology, vol.80, issue.6, pp.1298-1302, 2012.
DOI : 10.1016/j.urology.2012.08.013

J. Zhang, C. Zhang, L. Hu, Y. He, Z. Shi et al., Abnormal Expression of miR-21 and miR-95 in Cancer Stem-Like Cells is Associated with Radioresistance of Lung Cancer, Cancer Investigation, vol.83, issue.5, pp.165-71
DOI : 10.1002/biof.1030

K. Zhang, L. Han, L. Chen, Z. Shi, M. Yang et al., Blockage of a miR-21/EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas. Cancer Letters, pp.139-188, 2014.

J. Zhou, K. Wang, W. Wu, S. Subramaniam, J. Shyy et al., MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to 115

R. Zhou, G. Hu, A. Gong, and X. Chen, Binding of NF-kappaB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes in human biliary epithelial cells, Nucleic Acids Research, vol.175, issue.6, pp.3222-3254, 2010.
DOI : 10.4049/jimmunol.175.11.7447

S. Zhu, M. Si, H. Wu, and Y. Mo, ), Journal of Biological Chemistry, vol.13, issue.19, pp.14328-14364, 2007.
DOI : 10.1091/mbc.8.5.897

S. Zhu, H. Wu, F. Wu, D. Nie, S. Sheng et al., MicroRNA-21 targets tumor suppressor genes in invasion and metastasis, Cell Research, vol.60, issue.3, pp.350-359, 2008.
DOI : 10.1016/j.bbrc.2006.02.106

URL : http://www.nature.com/cr/journal/v18/n3/pdf/cr200824a.pdf

A. Zielezinski and W. Karlowski, Early origin and adaptive evolution of the GW182 protein family, the key component of RNA silencing in animals, RNA Biology, vol.13, issue.7, pp.761-70, 2015.
DOI : 10.1016/S0092-8674(02)01003-6

L. Zini, P. Perrotte, C. Jeldres, U. Capitanio, D. Pharand et al., Nephrectomy improves the survival of patients with locally advanced renal cell carcinoma, BJU International, vol.49, issue.11, pp.1610-1614, 2008.
DOI : 10.1111/j.1464-410X.2008.07917.x

URL : https://hal.archives-ouvertes.fr/hal-00315989

J. Zipprich, S. Bhattacharyya, H. Mathys, and W. Filipowicz, Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression, RNA, vol.15, issue.5, pp.781-93, 2009.
DOI : 10.1261/rna.1448009