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Dissection fonctionnelle des spécificités et des redondances des facteurs de transcription de la famille Ikaros dans les lymphocytes T

Abstract : The lkaros transcription factor family is made of the proteins lkaros, Helios, Aiolos and Eos. They are expressed during the development and regulate the differentiation of lymphocytes B and T. These proteins present a strong homology between their nucleic and protein sequences and are involved the appearance of T or B lymphoblastic leukaemia. However these factors present strong differences in their profiles of expression, their functions and their target genes. An immature T cell line, deficient for lkaros, allows us to study the functional and molecular differences of members of the family. There-expression of lkaros, Aiolos and Helios allows the differentiation and the decrease of the proliferation of these cells. I also showed that the various members of the family had different capacities to activate or repress certain target genes. An exchange of the protein sequences coding for the DNA binding domain (DBD), shows that the functional specificity is partially determined by the DBD domain, but also by the other regions of lkaros and Aiolos.
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Submitted on : Tuesday, January 30, 2018 - 2:59:13 PM
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Marie Goepp. Dissection fonctionnelle des spécificités et des redondances des facteurs de transcription de la famille Ikaros dans les lymphocytes T. Génomique, Transcriptomique et Protéomique [q-bio.GN]. Université de Strasbourg, 2015. Français. ⟨NNT : 2015STRAJ043⟩. ⟨tel-01696561⟩

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