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Vasopressine, hydratation et fonction rénale

Abstract : Chronic kidney disease (CKD) is currently recognized as a major public health problem. In the last few years, more attention has been paid to the vasopressin-hydration axis in clinical research. Epidemiological studies have identified a positive association between plasma concentrations of copeptin, a surrogate of vasopressin, and the decline of kidney function in populations at high risk of CKD. In the general population, data are limited. The likelihood of a causal relationship between elevated vasopressin and kidney function decline is strongly supported with demonstration in animal models of the deleterious effects of vasopressin in both normal and diabetic settings. Yet, all aspects of this relationship have not been explored. Two of them were addressed in this project: the contribution of vasopressin to the renal complications of type 2 diabetes (experimental approach) and the association between copeptin and the decline of kidney function in the general population, taking into account sex as a potential interaction factor (epidemiological approach). Vasopressin V2 receptor antagonism slows the progression of diabetic nephropathy in a murine model of type 2 diabetes. Analysis of data from three European community-based cohorts showed that high levels of copeptin are associated with risk of new-onset CKD with no indication of a sex-copeptin interaction in this association. These data provide new arguments in favour of decreasing vasopressin levels and/or action on the kidney, whether by pharmacological blockade or by an increase in water intake.
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https://tel.archives-ouvertes.fr/tel-01695519
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Submitted on : Monday, January 29, 2018 - 2:28:07 PM
Last modification on : Sunday, October 25, 2020 - 5:13:28 PM
Long-term archiving on: : Friday, May 25, 2018 - 2:23:32 PM

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  • HAL Id : tel-01695519, version 1

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Ray El Boustany. Vasopressine, hydratation et fonction rénale. Physiologie [q-bio.TO]. Université Pierre et Marie Curie - Paris VI, 2017. Français. ⟨NNT : 2017PA066261⟩. ⟨tel-01695519⟩

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