A mesoscale investigation of the endothelial glycocalyx and its interaction with blood flow

Abstract : Polymer brushes are dense matrices of grafted macromolecules. In addition to brushes finely designed in laboratory, various examples are offered by Nature, as the endothelial glycocalyx, decorating the lumen of mammalian blood vessels. The interaction of such network with the flowing plasma and cells is still partially unknown.The present thesis, by mean of Dissipative Particle Dynamics simulations, proposes a coarse-grained model for the self-consistent analysis of a dense polymer brush under parabolic flow. Our mesoscale investigation highlights the relevance of collective effects, driven by hydrodynamics, and proposes novel interpretations regarding the rich phenomenology of the brush-flow system.Preliminary results are also provided for the interplay between a mesoscopic deformable flowing object (prototype of a red blood cell) and the grafted polymers.
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Sofia Biagi. A mesoscale investigation of the endothelial glycocalyx and its interaction with blood flow. Human health and pathology. Université Grenoble Alpes, 2016. English. ⟨NNT : 2016GREAY083⟩. ⟨tel-01693743⟩

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