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Τοmοscintigraphie myοcardique dοuble-isοtοpe (¹²³Ι/99mΤc) sur gamma-caméra à semi-cοnducteur : aspects méthodologiques et applications cliniques

Abstract : New dedicated-cardiac cameras using CZT detectors have dramatically transformed the routine of myocardial perfusion imaging. With a better count detection sensitivity, an improved spatial and energy resolution, they potentially enable combined assessment of myocardial innervation (123I) and perfusion (99mTc) within a single imaging session. These cameras images with different sharpness and contrast-to-noise ratios.Using two CZT cameras with anthropomorphic phantom, and clinical studies in heart failure patients, our work focused on (i) the left ventricular function assessment within the 99mTc window in presence of 123I, (ii) the evaluation of regional myocardial innervation (123I) and perfusion (99mTc) match and mismatch with single- (separate 123I and 99mTc acquisition) and simultaneous dual-isotope acquisitions, and (iii) the late heart-to-mediastinal ratio (HMR) of 123I-MIBG uptake determined using dual-isotope CZT acquisition with that determined using conventional planar imaging in patients with heart failure.Our results found no impact of the acquisition mode (single vs dual) or the type of CZT camera on 123I and 99mTc defect size and mismatch, LVEF, and HMR of 123I-MIBG uptake.This work provides a new step toward simultaneous dual-isotope acquisition for combined innervation, perfusion and ventricular function assessment.
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https://tel.archives-ouvertes.fr/tel-01693259
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Submitted on : Friday, January 26, 2018 - 9:25:24 AM
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  • HAL Id : tel-01693259, version 1

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Tanguy Blaire. Τοmοscintigraphie myοcardique dοuble-isοtοpe (¹²³Ι/99mΤc) sur gamma-caméra à semi-cοnducteur : aspects méthodologiques et applications cliniques. Médecine humaine et pathologie. Normandie Université, 2017. Français. ⟨NNT : 2017NORMC418⟩. ⟨tel-01693259⟩

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