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Effets du vieillissement normal sur la production lexicale : approche pluridisciplinaire

Abstract : Normal aging is associated with cognitive difficulties in many domains except for language, which is still under debate. However, older adults report difficulties in lexical production, which are also known to be associated with pathological aging, such as Alzheimer’s disease. This work aimed first to characterize the changes in the cognitive processes involved in lexical production using a behavioral approach, then to characterize the associated neurofunctional and vascular changes using fMRI. In the first study including 72 healthy participants, aged between 30 and 84 years, we showed a differential aging effect on lexical production and semantic processing. Naming was well preserved in terms of competences in normal aging; nevertheless, it was affected by the general cognitive slowdown. However, semantic processing was more affected by aging, probably due to inefficient executive control. The second study using fMRI confirmed these results and suggested the establishment of compensatory mechanisms to overcome cognitive difficulties. Finally, in the third study using vascular fMRI we described basal and functional cerebral perfusion modifications in normal aging as well as at early stages of pathological aging. We showed a strong relationship between the hemodynamical properties and the cognitive abilities. This multidisciplinary approach combining behavioral, neuropsychological, neurofunctional and cerebral perfusion imaging studies, provided a more complete picture of cerebral and cognitive changes in lexical production during normal aging.
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Submitted on : Thursday, January 25, 2018 - 3:08:12 PM
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  • HAL Id : tel-01692870, version 1



Naïla Boudiaf. Effets du vieillissement normal sur la production lexicale : approche pluridisciplinaire. Psychologie. Université Grenoble Alpes, 2016. Français. ⟨NNT : 2016GREAS029⟩. ⟨tel-01692870⟩



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