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L'hypertrophie de la prostate et la rétention aiguë d'urine : vers un stent urétral à base de bio-matériaux NiTi et silicone

Abstract : Acute urinary retention is the major complication of benign prostatic hyperplasia. Today, the first line treatment consists in emergency catheterization, which often leads to urinary infection. This thesis aimed at developing an innovative nitinol based stent as a alternative treatment for acute urinary retention. Using a combination of NiTi wires and tubes, this stent is given two distinct shape memories during heating.The stent components are mostly loaded under pure bending during the stent activation. A pure bending apparatus allowing large deformations on slender specimens was thus designed. This device gave access to the NiTi wires and tubes behaviour under pure bending, and also provided information about localization phenomena during pure bending experiment.A numerical method able to identify the shear-stress shear-strain function from experimental pure torsion tests, and the stress strain function under compressive load from experimental uni-axial tensile and pure bending tests was also developed. This method was applied using afore-obtained numerical results to identify the NiTi wires and tubes behaviour under uni-axial compressive load.
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Gabriel Antherieu. L'hypertrophie de la prostate et la rétention aiguë d'urine : vers un stent urétral à base de bio-matériaux NiTi et silicone. Médecine humaine et pathologie. Université Grenoble Alpes, 2016. Français. ⟨NNT : 2016GREAS001⟩. ⟨tel-01691750⟩

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